Literature DB >> 3501289

Primary structure of human pancreatic secretory trypsin inhibitor (PSTI) gene.

A Horii1, T Kobayashi, N Tomita, T Yamamoto, S Fukushige, T Murotsu, M Ogawa, T Mori, K Matsubara.   

Abstract

The human pancreatic secretory trypsin inhibitor (PSTI) gene was isolated from a human gene library. Restriction endonuclease mapping and DNA sequencing analysis revealed that this gene is approximately 7.5 kb long and is separated into four exons by three introns. The gene has multiple transcription start points and examination with a single-laser cell-sorter showed that it is located on chromosome 5.

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Year:  1987        PMID： 3501289     DOI： 10.1016/0006-291x(87)90415-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  17 in total

1.  [-215G>A; IVS3+2T>C] mutation in the SPINK1 gene causes exon 3 skipping and loss of the trypsin binding site.

Authors:  K Kume; A Masamune; K Kikuta; T Shimosegawa
Journal:  Gut       Date:  2006-08       Impact factor: 23.059

2.  A male reproduction-related Kazal-type peptidase inhibitor gene in the prawn, Macrobrachium rosenbergii: molecular characterization and expression patterns.

Authors:  Jun-Xia Cao; Jie-Qiong Dai; Zhong-Min Dai; Guo-Li Yin; Wei-Jun Yang
Journal:  Mar Biotechnol (NY)       Date:  2006-09-15       Impact factor: 3.619

3.  SPINK1 Overexpression in Localized Prostate Cancer: a Rare Event Inversely Associated with ERG Expression and Exclusive of Homozygous PTEN Deletion.

Authors:  Kuo-Cheng Huang; Andrew Evans; Bryan Donnelly; Tarek A Bismar
Journal:  Pathol Oncol Res       Date:  2016-10-13       Impact factor: 3.201

Review 4.  Genetics of acute and chronic pancreatitis: An update.

Authors:  Vv Ravi Kanth; D Nageshwar Reddy
Journal:  World J Gastrointest Pathophysiol       Date:  2014-11-15

5.  Association of rare SPINK1 gene mutation with another base substitution in chronic pancreatitis patients.

Authors:  Viacheslav N Kalinin; Jussuf T Kaifi; Heidi Schwarzenbach; Anatoly S Sergeyev; Bjoern C Link; Dean Bogoevski; Yogesh Vashist; Jakob R Izbicki; Emre F Yekebas
Journal:  World J Gastroenterol       Date:  2006-09-07       Impact factor: 5.742

6.  Germline mutations in CFTR and PSTI genes in chronic pancreatitis patients.

Authors:  Ezio Gaia; Paola Salacone; Monica Gallo; Gianni Gerbino Promis; Alfredo Brusco; Claudia Bancone; Arduino Carlo
Journal:  Dig Dis Sci       Date:  2002-11       Impact factor: 3.199

7.  The N34S mutation of SPINK1 (PSTI) is associated with a familial pattern of idiopathic chronic pancreatitis but does not cause the disease.

Authors:  J Threadgold; W Greenhalf; I Ellis; N Howes; M M Lerch; P Simon; J Jansen; R Charnley; R Laugier; L Frulloni; A Oláh; M Delhaye; I Ihse; O B Schaffalitzky de Muckadell; A Andrén-Sandberg; C W Imrie; J Martinek; T M Gress; R Mountford; D Whitcomb; J P Neoptolemos
Journal:  Gut       Date:  2002-05       Impact factor: 23.059

8.  Absence of PRSS1 mutations and association of SPINK1 trypsin inhibitor mutations in hereditary and non-hereditary chronic pancreatitis.

Authors:  G R Chandak; M M Idris; D N Reddy; K R Mani; S Bhaskar; G V Rao; L Singh
Journal:  Gut       Date:  2004-05       Impact factor: 23.059

9.  Overexpression of pancreatic secretory trypsin inhibitor in pancreatic cancer. Evaluation of its biological function as a growth factor.

Authors:  Y Ohmachi; A Murata; N Matsuura; T Yasuda; K Uda; T Mori
Journal:  Int J Pancreatol       Date:  1994-02

10.  Influence of inflammatory bowel disease on the distribution and concentration of pancreatic secretory trypsin inhibitor within the colon.

Authors:  R J Playford; A M Hanby; K Patel; J Calam
Journal:  Am J Pathol       Date:  1995-02       Impact factor: 4.307
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