| Literature DB >> 35006906 |
Galina B Guseva1, Elena V Antina1, Mikhail B Berezin1, Roman S Pavelyev2, Airat R Kayumov2, Olga V Ostolopovskaya2, Ilmir R Gilfanov3, Larisa L Frolova4, Alexander V Kutchin4, Rustem F Akhverdiev2, Svetlana A Lisovskaya5, Elena Y Trizna2, Olga A Lodochnikova2,6, Daut R Islamov2,6, Sergey V Efimov2, Vladimir V Klochkov2, Ilya A Khodov1,2, Sergei V Boichuk3, Liliya E Nikitina2,3.
Abstract
This article describes the design and biological properties of a BODIPY FL-labeled monoterpenoid BF2-meso-(4-((1″R)-6″,6″-dimethylbicyclo[3.1.1]hept-2″-ene-2″)yl-methoxycarbonylpropyl)-3,3',5,5'-tetramethyl-2,2'-dipyrromethene conjugate (BODIPYmyrt). The fluorophore was characterized using X-ray, NMR, MS, and UV/vis spectroscopy. The conjugate exhibits a high quantum yield (to ∼100%) in the region 515-518 nm. BODIPYmyrt effectively penetrates the membranes of the bacterial and fungal cells and therefore can be used to examine the features of a broad spectrum of Gram-positive and Gram-negative bacteria and pathogenic fungi as well. Moreover, BODIPYmyrt exhibits a moderate tropism to the subcellular structures in mammalian cells (e.g., mitochondria), thereby providing an attractive scaffold for fluorophores to examine these particular organelles.Entities:
Keywords: (+)-myrtenol; BODIPY FL-labeled monoterpenoid; biovisualization; conjugate; spectral properties; structure
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Year: 2021 PMID： 35006906 DOI： 10.1021/acsabm.1c00550
Source DB: PubMed Journal: ACS Appl Bio Mater ISSN： 2576-6422