Sneha Mantri1, Lana M Chahine2, Karina Nabieva3, Robert Feldman4, Andrew Althouse4, Benjamin Torsney5, Steven M Albert6, Catherine Kopil7, Connie Marras3. 1. Department of Neurology Duke University School of Medicine Durham North Carolina USA. 2. Department of Neurology University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA. 3. The Edmond J Safra Program in Parkinson's disease Toronto Western Hospital, University of Toronto Toronto Ontario Canada. 4. Center for Clinical Trials and Data Coordination, Division of General Internal Medicine University of Pittsburgh School of Medicine Pittsburgh Pennsylvania USA. 5. Temple University College of Education and Human Development Philadelphia Pennsylvania USA. 6. Behavioral and Community Health Sciences, Graduate School of Public Health University of Pittsburgh Pittsburgh Pennsylvania USA. 7. The Michael J. Fox Foundation New York New York USA.
Abstract
BACKGROUND: Fatigue has a major impact on health-related quality of life (HR-QOL) in Parkinson's disease (PD). OBJECTIVES: To determine whether demographic characteristics modify the relationship between fatigue and HR-QOL. METHODS: Patients with PD in the Fox Insight study completed the Parkinson Fatigue Scale (PFS-16) and Geriatric Depression Scale (GDS-15). Linear regression examined the relationship between the PFS-16 and Parkinson Disease Quality of Life, as modified by age, sex, and GDS-15. RESULTS: A total of 1029 participants (44% female, mean age 67.4 years, and mean disease duration 4.6 years) were included in this analysis. Multivariable regression modeling demonstrated a negative effect modification for age (β = -0.07, P < 0.001) and a positive effect modification for the GDS-15 (β = 0.057, P = 0.002), but not for sex (β = -0.021, P = 0.231). CONCLUSION: The association between fatigue and worse HR-QOL is greater at younger ages and in individuals with more depressive symptoms. Targeted therapeutics for these individuals may provide the greatest impact on fatigue in PD.
BACKGROUND: Fatigue has a major impact on health-related quality of life (HR-QOL) in Parkinson's disease (PD). OBJECTIVES: To determine whether demographic characteristics modify the relationship between fatigue and HR-QOL. METHODS: Patients with PD in the Fox Insight study completed the Parkinson Fatigue Scale (PFS-16) and Geriatric Depression Scale (GDS-15). Linear regression examined the relationship between the PFS-16 and Parkinson Disease Quality of Life, as modified by age, sex, and GDS-15. RESULTS: A total of 1029 participants (44% female, mean age 67.4 years, and mean disease duration 4.6 years) were included in this analysis. Multivariable regression modeling demonstrated a negative effect modification for age (β = -0.07, P < 0.001) and a positive effect modification for the GDS-15 (β = 0.057, P = 0.002), but not for sex (β = -0.021, P = 0.231). CONCLUSION: The association between fatigue and worse HR-QOL is greater at younger ages and in individuals with more depressive symptoms. Targeted therapeutics for these individuals may provide the greatest impact on fatigue in PD.
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