Rohit Bhatia1, M V Padma Srivastava1, P N Sylaja2, Snigdha Komakula1, Ashish Upadhyay3, Vibhor Pardasani4, Thomas Iype5, Rajsrinivas Parthasarathy6,7, Rajshekhar Reddy5, Suman Kushwaha8, Jayanta Roy9, P Satish1, Anjan Trikha10, Naveet Wig11, Lalit Dhar12, Deepti Vibha1, Venugopalan Y Vishnu1, Awadh Kishore Pandit1, Anu Gupta1, A Elavarasi1, Ayush Agarwal1, Vipul Gupta7, Rakesh K Singh4, Harsh Oza4, Hiral Halani4, Dileep Ramachandran5, Githin B George5, Praveen Panicker5, M K Suresh12, S Kumaravelu13, Dheeraj Khurana14, Srijithesh P Rajendran15, Vijaya Pamidimukkala16, Salil Gupta17, Jeyaraj D Pandian18, Debashish Chowdhury19, Nirendra K Rai20, Arvind Sharma21, Vivek K Nambiar22. 1. Department of Neurology, All India Institute of Medical Sciences, New Delhi, India. 2. Department of Neurology, Sree Chitra Thirunal Institute for Medical Sciences and Technology, Thiruvananthapuram, Kerala, India. 3. Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India. 4. Department of Neurology, Bombay Hospital and Medical Research Centre, Mumbai, Maharashtra, India. 5. Department of Neurology, Government Medical College Thiruvananthapuram, Thiruvananthapuram, Kerala, India. 6. Department of Neurology, Artemis Hospitals, Gurgaon, Haryana, India. 7. Department of Neurointervention Surgery, Artemis Hospitals, Gurgaon, Haryana, India. 8. Department of Neurology, Institute of Human Behaviour and Allied Sciences, Neurology, New Delhi, India. 9. Department of Neurology, Institute of Neurosciences, Kolkata, West Bengal, India. 10. Department of Anaesthesia, All India Institute of Medical Sciences, New Delhi, India. 11. Department of Medicine, All India Institute of Medical Sciences, New Delhi, India. 12. Department of Microbiology, All India Institute of Medical Sciences, New Delhi, India. 13. Department of Neurology, Ramesh Hospitals Guntur, Andhra Pradesh, India. 14. Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. 15. Department of Neurology, National Institute of Mental Health and Neuro Sciences, Bangalore, Karnataka, India. 16. Department of Neurology, Lalitha Super Specialty Hospital, Guntur, Andhra Pradesh, India. 17. Department of Neurology, Command Hospital Air Force Bangalore, Bangalore, Karnataka, India. 18. Department of Neurology, Christian Medical College, Ludhiana, Punjab, India. 19. Department of Neurology, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, New Delhi, Delhi, India. 20. Department of Neurology, All India Institute of Medical Sciences, Bhopal, Madhya Pradesh, India. 21. Department of Neurology, Zydus Hospital, Ahmedabad, Gujarat, India. 22. Department of Neurology, Amrita Institute of Medical Sciences, Cochin, Kerala.
Abstract
BACKGROUND AND PURPOSE: Occurrence of stroke has been reported among patients with COVID-19. The present study compares clinical features and outcomes of stroke patients with and without COVID-19. METHODS: The COVID-19 Stroke Study Group (CSSG) is a multicentric study in 18 sites across India to observe and compare the clinical characteristics of patients with stroke admitted during the current pandemic period and a similar epoch in 2019. The present study reports patients of stroke with and without COVID-19 (CoVS and non-CoVS, respectively) seen between February 2020 and July 2020. Demographic, clinical, treatment, and outcome details of patients were collected. RESULTS: The mean age and gender were comparable between the two groups. CoVS patients had higher stroke severity and extent of cerebral involvement on imaging. In-hospital complications and death were higher among CoVS patients (53.06% vs. 17.51%; P < 0.001) and (42.31% vs. 7.6%; P < 0.001), respectively. At 3 months, higher mortality was observed among CoVS patients (67.65% vs. 13.43%; P < 0.001) and good outcome (modified Rankin score [mRS]: 0-2) was seen more often in non-CoVS patients (68.86% vs. 33.33%; P < 0.001). The presence of COVID-19 and baseline stroke severity were independent predictors of mortality. CONCLUSIONS: CoVS is associated with higher severity, poor outcome, and increased mortality. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and baseline stroke severity are independent predictors of mortality. Copyright:
BACKGROUND AND PURPOSE: Occurrence of stroke has been reported among patients with COVID-19. The present study compares clinical features and outcomes of stroke patients with and without COVID-19. METHODS: The COVID-19 Stroke Study Group (CSSG) is a multicentric study in 18 sites across India to observe and compare the clinical characteristics of patients with stroke admitted during the current pandemic period and a similar epoch in 2019. The present study reports patients of stroke with and without COVID-19 (CoVS and non-CoVS, respectively) seen between February 2020 and July 2020. Demographic, clinical, treatment, and outcome details of patients were collected. RESULTS: The mean age and gender were comparable between the two groups. CoVS patients had higher stroke severity and extent of cerebral involvement on imaging. In-hospital complications and death were higher among CoVS patients (53.06% vs. 17.51%; P < 0.001) and (42.31% vs. 7.6%; P < 0.001), respectively. At 3 months, higher mortality was observed among CoVS patients (67.65% vs. 13.43%; P < 0.001) and good outcome (modified Rankin score [mRS]: 0-2) was seen more often in non-CoVS patients (68.86% vs. 33.33%; P < 0.001). The presence of COVID-19 and baseline stroke severity were independent predictors of mortality. CONCLUSIONS: CoVS is associated with higher severity, poor outcome, and increased mortality. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and baseline stroke severity are independent predictors of mortality. Copyright:
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