Literature DB >> 35001654

High-Altitude Erythrocytosis: Mechanisms of Adaptive and Maladaptive Responses.

Francisco C Villafuerte1, Tatum S Simonson2, Daniela Bermudez1, Fabiola León-Velarde1.   

Abstract

Erythrocytosis, or increased production of red blood cells, is one of the most well-documented physiological traits that varies within and among in high-altitude populations. Although a modest increase in blood O2-carrying capacity may be beneficial for life in highland environments, erythrocytosis can also become excessive and lead to maladaptive syndromes such as chronic mountain sickness (CMS).

Entities:  

Keywords:  chronic hypoxia; chronic mountain sickness; excessive erythrocytosis; high-altitude erythrocytosis

Mesh：

Year:  2022        PMID： 35001654      PMCID： PMC9191173          DOI： 10.1152/physiol.00029.2021

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN： 1548-9221


  107 in total

1.  Strong association between polycythemia and glucose intolerance in older adults living at high altitudes in the Andes.

Authors:  Kiyohito Okumiya; Ryota Sakamoto; Eriko Fukutomi; Yumi Kimura; Yasuko Ishimoto; Wen-ling Chen; Motonao Ishikawa; Reiko Hozo; Kuniaki Otsuka; Kozo Matsubayashi; Taizo Wada; Tetsuya Inamura; Marcela Lazo; Jose Perez Lu; Patricia J Garcia
Journal:  J Am Geriatr Soc       Date:  2011-10       Impact factor: 5.562

Review 2.  Nitric oxide in adaptation to altitude.

Authors:  Cynthia M Beall; Daniel Laskowski; Serpil C Erzurum
Journal:  Free Radic Biol Med       Date:  2012-01-20       Impact factor: 7.376

Review 3.  Physiological adaptation to high altitude: oxygen transport in mammals and birds.

Authors:  C Monge; F León-Velarde
Journal:  Physiol Rev       Date:  1991-10       Impact factor: 37.312

4.  Reevaluation of excessive erythrocytosis in diagnosing chronic mountain sickness in men from the world's highest city.

Authors:  Laura Oberholzer; Carsten Lundby; Emeric Stauffer; Mathilde Ulliel-Roche; Ivan Hancco; Aurélien Pichon; Anne-Kristine Meinild Lundby; Francisco C Villafuerte; Samuel Verges; Paul Robach
Journal:  Blood       Date:  2020-10-15       Impact factor: 22.113

5.  Increased diffusion capacity maintains arterial saturation during exercise in the Quechua Indians of Chilean Altiplano.

Authors:  R B Schoene; R C Roach; S Lahiri; R M Peters; P H Hackett; R Santolaya
Journal:  Am J Hum Biol       Date:  1990       Impact factor: 1.937

6.  Office and Ambulatory Arterial Hypertension in Highlanders: HIGHCARE-ANDES Highlanders Study.

Authors:  Francisco C Villafuerte; Gianfranco Parati; Grzegorz Bilo; Lorenzo Acone; Cecilia Anza-Ramírez; José Luis Macarlupú; Davide Soranna; Antonella Zambon; Gustavo Vizcardo-Galindo; Martino F Pengo
Journal:  Hypertension       Date:  2020-11-11       Impact factor: 10.190

7.  Increased Cardiometabolic Risk and Worsening Hypoxemia at High Altitude.

Authors:  Catherine H Miele; Alan R Schwartz; Robert H Gilman; Luu Pham; Robert A Wise; Victor G Davila-Roman; Jonathan C Jun; Vsevolod Y Polotsky; J Jaime Miranda; Fabiola Leon-Velarde; William Checkley
Journal:  High Alt Med Biol       Date:  2016-06       Impact factor: 1.981

8.  Perinatal hypoxia increases susceptibility to high-altitude polycythemia and attendant pulmonary vascular dysfunction.

Authors:  Colleen Glyde Julian; Marcelino Gonzales; Armando Rodriguez; Diva Bellido; Carlos Salinas Salmon; Anne Ladenburger; Lindsay Reardon; Enrique Vargas; Lorna G Moore
Journal:  Am J Physiol Heart Circ Physiol       Date:  2015-06-19       Impact factor: 5.125

9.  Altitude adaptation in Tibetans caused by introgression of Denisovan-like DNA.

Authors:  Emilia Huerta-Sánchez; Xin Jin; Zhuoma Bianba; Benjamin M Peter; Nicolas Vinckenbosch; Yu Liang; Xin Yi; Mingze He; Mehmet Somel; Peixiang Ni; Bo Wang; Xiaohua Ou; Jiangbai Luosang; Zha Xi Ping Cuo; Kui Li; Guoyi Gao; Ye Yin; Wei Wang; Xiuqing Zhang; Xun Xu; Huanming Yang; Yingrui Li; Jian Wang; Jun Wang; Rasmus Nielsen
Journal:  Nature       Date:  2014-07-02       Impact factor: 49.962

10.  Excessive Erythrocytosis and Cardiovascular Risk in Andean Highlanders.

Authors:  Noemí Corante; Cecilia Anza-Ramírez; Rómulo Figueroa-Mujíca; José Luis Macarlupú; Gustavo Vizcardo-Galindo; Grzegorz Bilo; Gianfranco Parati; Jorge L Gamboa; Fabiola León-Velarde; Francisco C Villafuerte
Journal:  High Alt Med Biol       Date:  2018-05-21       Impact factor: 1.981
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  1 in total

1.  A Critical Analysis of the Automated Hematology Assessment in Pregnant Women at Low and at High Altitude: Association between Red Blood Cells, Platelet Parameters, and Iron Status.

Authors:  Ramón Figueroa-Mujica; Luis Angel Ccahuantico; Maycol Suker Ccorahua-Rios; Juan José Sanchez-Huaman; Cinthya Vásquez-Velasquez; Jorge M Ponce-Huarancca; Rodrigo E Rozas-Gamarra; Gustavo F Gonzales
Journal:  Life (Basel)       Date:  2022-05-13
  1 in total

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