Literature DB >> 35001653

Pathophysiology of Hemorrhage as It Relates to the Warfighter.

Carmen Hinojosa-Laborde1, Ian L Hudson1, Evan Ross1, Lusha Xiang1, Kathy L Ryan1.   

Abstract

Saving lives of wounded military warfighters often depends on the ability to resolve or mitigate the pathophysiology of hemorrhage, specifically diminished oxygen delivery to vital organs that leads to multiorgan failure and death. However, caring for hemorrhaging patients on the battlefield presents unique challenges that extend beyond applying a tourniquet and giving a blood transfusion, especially when battlefield care must be provided for a prolonged period. This review describes these challenges and potential strategies for treating hemorrhage on the battlefield in a prolonged casualty care situation.

Entities:  

Keywords:  battlefield; hemorrhage; prolonged casualty care; trauma

Mesh:

Year:  2022        PMID: 35001653      PMCID: PMC8977138          DOI: 10.1152/physiol.00028.2021

Source DB:  PubMed          Journal:  Physiology (Bethesda)        ISSN: 1548-9221


  152 in total

1.  Extremity trauma exacerbates acute kidney injury following prolonged hemorrhagic hypotension.

Authors:  Lusha Xiang; Alfredo S Calderon; Harold G Klemcke; Ian L Hudson; Carmen Hinojosa-Laborde; Kevin K Chung; Kathy L Ryan
Journal:  J Trauma Acute Care Surg       Date:  2021-06-04       Impact factor: 3.313

2.  Progressive hemorrhage: administer oxygen or early resuscitation?

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Journal:  Intensive Care Med       Date:  2009-07-18       Impact factor: 17.440

3.  The need for dried plasma - a national issue.

Authors:  Anthony E Pusateri; Frank K Butler; Stacy A Shackelford; Jason L Sperry; Ernest E Moore; Andrew P Cap; Audra L Taylor; Mary J Homer; W Keith Hoots; Richard B Weiskopf; Michael R Davis
Journal:  Transfusion       Date:  2019-04       Impact factor: 3.157

Review 4.  Acute traumatic coagulopathy: The elephant in a room of blind scientists.

Authors:  Michael A Meledeo; Maryanne C Herzig; James A Bynum; Xiaowu Wu; Anand K Ramasubramanian; Daniel N Darlington; Kristin M Reddoch; Andrew P Cap
Journal:  J Trauma Acute Care Surg       Date:  2017-06       Impact factor: 3.313

5.  The therapeutic efficacy of opiate antagonists in hemorrhagic shock.

Authors:  D G Reynolds; N J Gurll; J W Holaday; R B Lechner
Journal:  Resuscitation       Date:  1989-12       Impact factor: 5.262

6.  Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.

Authors:  N S Chandel; E Maltepe; E Goldwasser; C E Mathieu; M C Simon; P T Schumacker
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-29       Impact factor: 11.205

7.  Tranexamic Acid During Prehospital Transport in Patients at Risk for Hemorrhage After Injury: A Double-blind, Placebo-Controlled, Randomized Clinical Trial.

Authors:  Francis X Guyette; Joshua B Brown; Mazen S Zenati; Barbara J Early-Young; Peter W Adams; Brian J Eastridge; Raminder Nirula; Gary A Vercruysse; Terence O'Keeffe; Bellal Joseph; Louis H Alarcon; Clifton W Callaway; Brian S Zuckerbraun; Matthew D Neal; Raquel M Forsythe; Matthew R Rosengart; Timothy R Billiar; Donald M Yealy; Andrew B Peitzman; Jason L Sperry
Journal:  JAMA Surg       Date:  2020-10-05       Impact factor: 14.766

8.  The Role of p66shc in Oxidative Stress and Apoptosis.

Authors:  E R Galimov
Journal:  Acta Naturae       Date:  2010-10       Impact factor: 1.845

9.  Back to the Future: Whole Blood Resuscitation of the Severely Injured Trauma Patient.

Authors:  Christopher Cameron McCoy; Megan Brenner; Juan Duchesne; Derek Roberts; Paula Ferrada; Tal Horer; David Kauvar; Mansoor Khan; Andrew Kirkpatrick; Carlos Ordonez; Bruno Perreira; Artai Priouzram; Bryan A Cotton
Journal:  Shock       Date:  2021-12-01       Impact factor: 3.454

Review 10.  Naloxone for shock.

Authors:  B Boeuf; V Poirier; F Gauvin; A M Guerguerian; C Roy; C A Farrell; J Lacroix
Journal:  Cochrane Database Syst Rev       Date:  2003
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  1 in total

1.  A novel animal model to study delayed resuscitation following traumatic hemorrhage.

Authors:  Lusha Xiang; Alfredo S Calderon; Harold G Klemcke; Carmen Hinojosa-Laborde; Sandra C Becerra; Kathy L Ryan
Journal:  J Appl Physiol (1985)       Date:  2022-08-25
  1 in total

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