Literature DB >> 35001313

Antithrombotic Activity of the Antiplatelet Agent Angipur on the Model of Arterial Thrombosis in Rats with Isoproterenol-Induced Myocardial Infarction.

A A Spasov1, A F Kucheryavenko1, F A Khaliullin2, N A Gurova1, V S Sirotenko3, A V Samorodov2, K A Gaidukova1, V N Pavlov2.   

Abstract

We studied the effect of Angipur on the process of experimental thrombosis induced by damage to the carotid artery wall by surface application of 50% ferric chloride (III) solution in rats without comorbidities and with isoproterenol-induced myocardial infarction. In animals without comorbidities, Angipur administered intravenously was 1.2 times less effective, in terms of ED50, than the well-known inhibitor of GPIIb/IIIa platelet receptors tirofiban. However, under conditions of non-coronary myocardial infarction, Angipur significantly prolonged the time of thrombus formation and exhibited 1.4-fold higher activity than the reference drug tirofiban.
© 2021. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Angipur; arterial thrombosis; isoproterenol-induced myocardial infarction; tirofiban

Mesh：

Substances：

Year:  2022        PMID： 35001313     DOI： 10.1007/s10517-022-05383-9

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  10 in total

Review 1.  Effects Of Glycoprotein IIb/IIIa Antagonists: Anti Platelet Aggregation And Beyond.

Authors:  Arturo Giordano; Giuseppe Musumeci; Anna D'Angelillo; Roberta Rossini; Giuseppe Biondi Zoccai; Stefano Messina; Enrico Coscioni; Simona Romano; Maria Fiammetta Romano
Journal:  Curr Drug Metab       Date:  2016       Impact factor: 3.731

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Authors:  A A Spasov; A F Kucheriavenko; M Tian'; V A Anisimova
Journal:  Eksp Klin Farmakol       Date:  2013

3.  Preventive effect of naringin on cardiac markers, electrocardiographic patterns and lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats.

Authors:  M Rajadurai; P Stanely Mainzen Prince
Journal:  Toxicology       Date:  2006-11-19       Impact factor: 4.221

4.  Rat model of arterial thrombosis induced by ferric chloride.

Authors:  K D Kurz; B W Main; G E Sandusky
Journal:  Thromb Res       Date:  1990-11-15       Impact factor: 3.944

5.  [ANTIAGGREGANT ACTIVITY OF A NEW TRICYCLIC BENZIMIDAZOLE DERIVATIVE.]

Authors:  A F Kucheryavenko; V A Anisimova; K A Gaidukova; L N Divaeva; T A Kuz'menko; A S Morkovnik; V S Sirotenko; A A Spasov
Journal:  Eksp Klin Farmakol       Date:  2016-08

Review 6.  Catecholamine cardiotoxicity.

Authors:  G Rona
Journal:  J Mol Cell Cardiol       Date:  1985-04       Impact factor: 5.000

7.  Cardioprotective activity of Ginkgo biloba Phytosomes in isoproterenol-induced myocardial necrosis in rats: a biochemical and histoarchitectural evaluation.

Authors:  Vandana S Panda; Suresh R Naik
Journal:  Exp Toxicol Pathol       Date:  2008-06-02

8.  Changes of lipid peroxides and alpha-tocopherol in rats with experimentally induced myocardial necrosis.

Authors:  Y Higuchi
Journal:  Acta Med Okayama       Date:  1982-04       Impact factor: 0.892

Review 9.  Platelets and platelet adhesion molecules: novel mechanisms of thrombosis and anti-thrombotic therapies.

Authors:  Xiaohong Ruby Xu; Naadiya Carrim; Miguel Antonio Dias Neves; Thomas McKeown; Tyler W Stratton; Rodrigo Matos Pinto Coelho; Xi Lei; Pingguo Chen; Jianhua Xu; Xiangrong Dai; Benjamin Xiaoyi Li; Heyu Ni
Journal:  Thromb J       Date:  2016-10-04

10.  Amelioration of Isoproterenol-Induced Oxidative Damage in Rat Myocardium by Withania somnifera Leaf Extract.

Authors:  Md Ibrahim Khalil; Istiyak Ahmmed; Romana Ahmed; E M Tanvir; Rizwana Afroz; Sudip Paul; Siew Hua Gan; Nadia Alam
Journal:  Biomed Res Int       Date:  2015-10-11       Impact factor: 3.411
  10 in total

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