| Literature DB >> 35001306 |
V V Kanygin1, A I Kasatova1,2, E L Zavjalov1,3, I A Razumov1,3, S I Kolesnikov4,5, A I Kichigin1, O I Solov'eva1,3, A R Tsygankova1,6, S Yu Taskaev1,2, D A Kasatov1,2, T V Sycheva1,2, V A Byvaltsev7,8.
Abstract
Boron neutron capture therapy (BNCT) can become an instrument for patients with malignant neoplasms of the rectum and colon. Here we evaluate the effectiveness of BNCT performed at the accelerator based epithermal neutron source at G. I. Budker Institute of Nuclear Physics, Siberian Division of Russian Academy of Sciences, in relation to subcutaneous xenografts of human colon adenocarcinoma SW-620 in SCID mice. Utilization of BNCT with boronоphenylalanine (BPA) and sodium borocaptate (BSH), which were injected intravenously into the retroorbital sinus, resulted in a significant decrease in tumor volumes compared to the control group (no radiation).Entities:
Keywords: accelerator based epithermal neutron source; boron neutron capture therapy; boronоphenylalanine; human colorectal adenocarcinoma; sodium borocaptate
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Year: 2022 PMID： 35001306 DOI： 10.1007/s10517-022-05392-8
Source DB: PubMed Journal: Bull Exp Biol Med ISSN： 0007-4888 Impact factor: 0.804