Literature DB >> 34999717

Testosterone replacement therapy and cardiovascular disease.

Jeremy M Auerbach1, Mohit Khera2.   

Abstract

The use of testosterone therapy has a complex history of apprehension and questions regarding its safety. Despite an eventual consensus that testosterone therapy was safe and effective, several studies relating to cardiovascular risks emerged in the last decade, rekindling skepticism regarding the safety of testosterone therapy. Given the utility of testosterone therapy in treating the symptoms of hypogonadism, it remains crucial to closely examine the safety of testosterone therapy. The present article synthesizes the current evidence regarding cardiovascular risks that may be associated with testosterone therapy, the potential mechanisms regarding testosterone's efficacy, and future directions in evaluating the safety of its use.
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

Entities:  

Year:  2022        PMID： 34999717     DOI： 10.1038/s41443-021-00516-6

Source DB:  PubMed          Journal:  Int J Impot Res        ISSN： 0955-9930            Impact factor:   2.408


  77 in total

Review 1.  Risks of testosterone-replacement therapy and recommendations for monitoring.

Authors:  Ernani Luis Rhoden; Abraham Morgentaler
Journal:  N Engl J Med       Date:  2004-01-29       Impact factor: 91.245

Review 2.  Testosterone therapy and cardiovascular risk: advances and controversies.

Authors:  Abraham Morgentaler; Martin M Miner; Monica Caliber; Andre T Guay; Mohit Khera; Abdulmaged M Traish
Journal:  Mayo Clin Proc       Date:  2015-02       Impact factor: 7.616

3.  Adverse events associated with testosterone administration.

Authors:  Shehzad Basaria; Andrea D Coviello; Thomas G Travison; Thomas W Storer; Wildon R Farwell; Alan M Jette; Richard Eder; Sharon Tennstedt; Jagadish Ulloor; Anqi Zhang; Karen Choong; Kishore M Lakshman; Norman A Mazer; Renee Miciek; Joanne Krasnoff; Ayan Elmi; Philip E Knapp; Brad Brooks; Erica Appleman; Sheetal Aggarwal; Geeta Bhasin; Leif Hede-Brierley; Ashmeet Bhatia; Lauren Collins; Nathan LeBrasseur; Louis D Fiore; Shalender Bhasin
Journal:  N Engl J Med       Date:  2010-06-30       Impact factor: 91.245

4.  Testosterone and cardiovascular risk: world's experts take unprecedented action to correct misinformation.

Authors:  Abraham Morgentaler; Bruno Lunenfeld
Journal:  Aging Male       Date:  2014-05-06       Impact factor: 5.892

Review 5.  Low Serum Testosterone in Outpatient Psychiatry Clinics: Addressing Challenges to the Screening and Treatment of Hypogonadism.

Authors:  Justin B Smith; Jordan Rosen; Adam Colbert
Journal:  Sex Med Rev       Date:  2017-11-08

Review 6.  Testosterone replacement therapy: For whom, when and how?

Authors:  Christos P Tsametis; Andrea M Isidori
Journal:  Metabolism       Date:  2018-03-09       Impact factor: 8.694

Review 7.  The History of Testosterone and the Evolution of its Therapeutic Potential.

Authors:  Abraham Morgentaler; Abdulmaged Traish
Journal:  Sex Med Rev       Date:  2018-04-13

8.  Increased risk of non-fatal myocardial infarction following testosterone therapy prescription in men.

Authors:  William D Finkle; Sander Greenland; Gregory K Ridgeway; John L Adams; Melissa A Frasco; Michael B Cook; Joseph F Fraumeni; Robert N Hoover
Journal:  PLoS One       Date:  2014-01-29       Impact factor: 3.240

9.  Endogenous sex hormones and prostate cancer: a collaborative analysis of 18 prospective studies.

Authors:  Andrew W Roddam; Naomi E Allen; Paul Appleby; Timothy J Key
Journal:  J Natl Cancer Inst       Date:  2008-01-29       Impact factor: 13.506

10.  Testosterone therapy and cardiovascular events among men: a systematic review and meta-analysis of placebo-controlled randomized trials.

Authors:  Lin Xu; Guy Freeman; Benjamin J Cowling; C Mary Schooling
Journal:  BMC Med       Date:  2013-04-18       Impact factor: 8.775
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