Literature DB >> 3499852

Recurrent HSR in the centromeric region of chromosome 8 in breast cancer.

M Gerbault-Seureau1, P Vielh, B Dutrillaux.   

Abstract

In a sample of 44 human breast cancers, the presence of HSRs was detected in 15 cases (36%). The occurrence of HSRs seems correlated poorly with tumor progression, but the number of HSRs per cell certainly does. Chromosome 8 was the most frequently involved, and the HSRs were always located near its centromere, suggesting that an amplification of gene(s) located in this region has occurred. Among these, LHRH is a candidate, but further studies are needed to confirm or reject this hypothesis.

Entities:  

Mesh：

Year:  1987        PMID： 3499852

Source DB:  PubMed          Journal:  Ann Genet        ISSN： 0003-3995


  6 in total

Review 1.  Genes other than BRCA1 and BRCA2 involved in breast cancer susceptibility.

Authors:  M M de Jong; I M Nolte; G J te Meerman; W T A van der Graaf; J C Oosterwijk; J H Kleibeuker; M Schaapveld; E G E de Vries
Journal:  J Med Genet       Date:  2002-04       Impact factor: 6.318

2.  Inherited DNA amplification of the proximal 15q region: cytogenetic and molecular studies.

Authors:  C Mignon; F Parente; C Stavropoulou; P Collignon; A Moncla; C Turc-Carel; M G Mattei
Journal:  J Med Genet       Date:  1997-03       Impact factor: 6.318

3.  Breast cancer genetic evolution: I. Data from cytogenetics and DNA content.

Authors:  B Dutrillaux; M Gerbault-Seureau; Y Remvikos; B Zafrani; M Prieur
Journal:  Breast Cancer Res Treat       Date:  1991-11       Impact factor: 4.872

4.  Phylogenomics of African guenons.

Authors:  Sibyle Moulin; Michèle Gerbault-Seureau; Bernard Dutrillaux; Florence Anne Richard
Journal:  Chromosome Res       Date:  2008-07-13       Impact factor: 5.239

5.  Proliferative activity of breast cancers increases in the course of genetic evolution as defined by cytogenetic analysis.

Authors:  Y Remvikos; M Gerbault-Seureau; H Magdelénat; M Prieur; B Dutrillaux
Journal:  Breast Cancer Res Treat       Date:  1992       Impact factor: 4.872

6.  Homogeneously staining regions in 223 breast carcinomas: cytogenetic and clinicopathological correlations.

Authors:  J Bernardino; M Gerbault-Seureau; B Zafrani; Y Dericke; E Boudou; H Magdelenat; B Dutrillaux
Journal:  Br J Cancer       Date:  1998-11       Impact factor: 7.640
  6 in total

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