| Literature DB >> 34998474 |
Aristine Cheng1, Steven M Holland2.
Abstract
Anticytokine autoantibodies can cause immunodeficiency or dysregulate immune responses. They may phenocopy genetically defined primary immunodeficiencies. We review current anti-type 1 and anti-type 2 interferon; anti-IL-12/23, anti-IL-17, and anti-GM-CSF autoantibodies; HLA associations; disease associations; and mechanistically based treatment options. Suspecting the presence of these autoantibodies in patients and identifying them at the onset of symptoms should ameliorate disease and improve outcomes.Entities:
Keywords: Anticytokine autoantibodies; adult-onset immunodeficiency; anti-IFN-alpha; anti–CM-CSF; anti–IFN-γ; anti–IL-12; anti–IL-17; anti–IL-23; chronic mucocutaneous candidiasis; opportunistic infections; protein alveolar proteinosis
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Year: 2022 PMID： 34998474 PMCID： PMC9034745 DOI： 10.1016/j.jaci.2021.11.016
Source DB: PubMed Journal: J Allergy Clin Immunol ISSN： 0091-6749 Impact factor: 14.290