Literature DB >> 34997875

The Role of Na+/K+-ATPase in the Development of Hyponatrenemia under Conditions of Hypoxic Stress in Patients with SARS-CoV-2 Infection.

S H Jafarova1, S A Adnaev2, R T Guliyeva3, N H Jafar2.   

Abstract

We studied laboratory parameters of patients with COVID-19 against the background of chronic pathologies (cardiovascular pathologies, obesity, type 2 diabetes melitus, and cardiovascular pathologies with allergy to statins). A decrease in pH and a shift in the electrolyte balance of blood plasma were revealed in all studied groups and were most pronounced in patients with cardiovascular pathologies with allergy to statin. It was found that low pH promotes destruction of lipid components of the erythrocyte membranes in patients with chronic pathologies, which was seen from a decrease in Na+/K+-ATPase activity and significant hyponatrenemia. In patients with cardiovascular pathologies and allergy to statins, erythrocyte membranes were most sensitive to a decrease in pH, while erythrocyte membranes of obese patients showed the greatest resistance to low pH and oxidative stress.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  COVID-19; Na+/K+-ATPase; erythrocyte membranes; hypoxia; lipid peroxidation

Mesh：

Substances：

Year:  2022        PMID： 34997875      PMCID： PMC8741565          DOI： 10.1007/s10517-022-05377-7

Source DB:  PubMed          Journal:  Bull Exp Biol Med        ISSN： 0007-4888            Impact factor:   0.804


  6 in total

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Review 5.  The Roles of Hypoxia Signaling in the Pathogenesis of Cardiovascular Diseases.

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Journal:  J Atheroscler Thromb       Date:  2017-07-28       Impact factor: 4.928

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  6 in total

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