| Literature DB >> 34997817 |
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Abstract
Entities:
Year: 2022 PMID: 34997817 PMCID: PMC8742227 DOI: 10.1111/jcmm.17076
Source DB: PubMed Journal: J Cell Mol Med ISSN: 1582-1838 Impact factor: 5.310
FIGURE 1Transplantation of MSCs‐IL‐10 improved neuronal morphology greater than MSCs alone in the cortex and hippocampus of TBI rats. Rat brains were sectioned and stained with 0.1% Cresyl violet, and images were taken by compound light microscope (Olympus) with 100× objectives (total mag 1000×). (A) Representative photomicrograph of TBI rats showed increase in number of pyknotic or tangle‐like cells in the cortex, in the CA1 and CA3 subfields of hippocampus. (B‐D) Number of pyknotic cells were significantly decreased by transplantation of MSCs‐IL‐10 in comparison with TBI rats (p < 0.01) and with TBI + MSCs (p < 0.01). The greater reduction in pyknotic cells was observed in the case of MSCs‐IL‐10 rats. Arrows indicate pyknotic or tangle‐like cells. Scale bar indicates 100 µm and is applicable to other images. **p < 0.01 in comparison with TBI + HBSS, TBI + MSCs‐IL‐10 and TBI + MSCs; *p < 0.05 in comparison with TBI + MSCs; ## p < 0.01 in comparison with TBI + MSCs