| Literature DB >> 34997814 |
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Abstract
Entities:
Year: 2022 PMID: 34997814 PMCID: PMC8742228 DOI: 10.1111/jcmm.17123
Source DB: PubMed Journal: J Cell Mol Med ISSN: 1582-1838 Impact factor: 5.310
FIGURE 1Effects of Dex on the lupus syndromes of MRL/lpr mice. Sixteen‐week‐old female MRL/lpr mice (36 ± 2 g) were treated with vehicle (normal saline) or 1 mg/kg of Dex for 4 weeks, age‐matched Balb/c mice as the normal control group. (A) Splenomegaly in MRL/lpr mice and alleviated after Dex treatment. (B) The serum levels of anti‐dsDNA antibodies and ANA. (C) Sections of kidney tissue were stained with H&E and semi‐quantitative analysis of the histological score. (D) Sections of kidney tissue were stained with immunofluorescence IgG and semi‐quantitative analysis of glomerular IgG deposition. Original magnification ×200. The scale bar in each image represents 100 μm. Values are the mean and SD of 5 mice per group, **p < .01 and ***p < .001