Literature DB >> 34997814

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Year:  2022        PMID: 34997814      PMCID: PMC8742228          DOI: 10.1111/jcmm.17123

Source DB:  PubMed          Journal:  J Cell Mol Med        ISSN: 1582-1838            Impact factor:   5.310


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In Chunxiu Shen et al., the HE‐stained picture of MRL/lpr + Dex group in Figure 1c is incorrect. The correct figure is shown below. The authors confirm all results and conclusions of this article remain unchanged.
FIGURE 1

Effects of Dex on the lupus syndromes of MRL/lpr mice. Sixteen‐week‐old female MRL/lpr mice (36 ± 2 g) were treated with vehicle (normal saline) or 1 mg/kg of Dex for 4 weeks, age‐matched Balb/c mice as the normal control group. (A) Splenomegaly in MRL/lpr mice and alleviated after Dex treatment. (B) The serum levels of anti‐dsDNA antibodies and ANA. (C) Sections of kidney tissue were stained with H&E and semi‐quantitative analysis of the histological score. (D) Sections of kidney tissue were stained with immunofluorescence IgG and semi‐quantitative analysis of glomerular IgG deposition. Original magnification ×200. The scale bar in each image represents 100 μm. Values are the mean and SD of 5 mice per group, **p < .01 and ***p < .001

Effects of Dex on the lupus syndromes of MRL/lpr mice. Sixteen‐week‐old female MRL/lpr mice (36 ± 2 g) were treated with vehicle (normal saline) or 1 mg/kg of Dex for 4 weeks, age‐matched Balb/c mice as the normal control group. (A) Splenomegaly in MRL/lpr mice and alleviated after Dex treatment. (B) The serum levels of anti‐dsDNA antibodies and ANA. (C) Sections of kidney tissue were stained with H&E and semi‐quantitative analysis of the histological score. (D) Sections of kidney tissue were stained with immunofluorescence IgG and semi‐quantitative analysis of glomerular IgG deposition. Original magnification ×200. The scale bar in each image represents 100 μm. Values are the mean and SD of 5 mice per group, **p < .01 and ***p < .001
  1 in total

1.  Dexamethasone reduces autoantibody levels in MRL/lpr mice by inhibiting Tfh cell responses.

Authors:  Chunxiu Shen; Xiaonan Xue; Xiaoyu Zhang; Lihua Wu; Xiangguo Duan; Chunxia Su
Journal:  J Cell Mol Med       Date:  2021-07-28       Impact factor: 5.310

  1 in total

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