Different Stability of DNA Origami Nanostructure between on Interface and in Bulk Solution.

DNA origami possesses a promising prospect in the fields including cancer therapy, enhancing catalytic activity, controllable nanorobot, etc. However, all the brilliant performances are based on its structural integrity, which is a big challenge for this technology. In this paper, we investigated the effects of interface on the stability of DNA origami and found that with treatments like heating, pH fluctuation, reducing ionic strength, the origami on interface always showed better stability than that in bulk solution because of the restriction imposed by the bond between solid surface and origami. Our results have great potential to inspire researchers to develop a complex that can provide origami an interface to strengthen its stability.