| Literature DB >> 3499495 |
H J Biersack1, D Linke, F Brassel, K Reichmann, M Kurthen, H F Durwen, B M Reuter, J Wappenschmidt, H Stefan.
Abstract
The lipophilic brain SPECT agent [99mTc]hexamethyl propylene amine oxime (HM-PAO) was used in three cases before and during unilateral anesthesia of one hemisphere for lateralization of speech dominance (Wada test). This procedure led to a decrease of regional cerebral blood flow (rCBF) in each of the hemispheres to 55 and 90%, respectively. Diminution of rCBF was significantly more pronounced in the dominant hemisphere. A second phenomenon observed during the Wada test was crossed cerebellar diaschisis. These findings support the assumption that HM-PAO allows monitoring of brain perfusion, as rapid changes of rCBF due to decreased neuronal activity cause respective alterations of cerebral and cerebellar uptake of this new brain agent.Entities:
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Year: 1987 PMID： 3499495
Source DB: PubMed Journal: J Nucl Med ISSN： 0161-5505 Impact factor: 10.057