Literature DB >> 3499485

HLA and multiple sclerosis in south east Wales.

R J Swingler1, P F Kirk, C Darke, D A Compston.   

Abstract

A stronger association has been found between multiple sclerosis and HLA-DR2 than -DQwl in south east Wales (prevalence c 113/10(5)) in contrast to recent observations in north east Scotland (prevalence 178/10(5). The complex relationship between the HLA system and multiple sclerosis, demonstrated in this and other studies, is explained more easily under a polygenic model of inheritance, in which environmental events and genes interact, than by the presence of a single susceptibility gene.

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Year:  1987        PMID： 3499485      PMCID： PMC1032347          DOI： 10.1136/jnnp.50.9.1153

Source DB:  PubMed          Journal:  J Neurol Neurosurg Psychiatry        ISSN： 0022-3050            Impact factor:   10.154


  7 in total

1.  Association between HLA-D region epitopes and multiple sclerosis in Arabs.

Authors:  A S Al-Din; M Al-Saffar; R Siboo; K Behbehani
Journal:  Tissue Antigens       Date:  1986-04

2.  A single mutation hypothesis for multiple sclerosis based on the HL-A system.

Authors:  P I Terasaki; M R Mickey
Journal:  Neurology       Date:  1976-06       Impact factor: 9.910

3.  The distribution of multiple sclerosis in the United Kingdom.

Authors:  R J Swingler; D Compston
Journal:  J Neurol Neurosurg Psychiatry       Date:  1986-10       Impact factor: 10.154

4.  Genetic analysis of multiple sclerosis in Orkney.

Authors:  D F Roberts; M J Roberts; D C Poskanzer
Journal:  J Epidemiol Community Health       Date:  1979-12       Impact factor: 3.710

5.  Multiple sclerosis and HLA DQw1.

Authors:  D A Francis; J R Batchelor; W I McDonald; J E Hern; A W Downie
Journal:  Lancet       Date:  1986-01-25       Impact factor: 79.321

6.  HLA-linked and unlinked determinants of multiple sclerosis.

Authors:  H Z Ho; J L Tiwari; R W Haile; P I Terasaki; N E Morton
Journal:  Immunogenetics       Date:  1982       Impact factor: 2.846

7.  The chief scientist reports ... multiple sclerosis in North East Scotland.

Authors:  A W Downie; J G Phadke
Journal:  Health Bull (Edinb)       Date:  1984-05
  7 in total
  7 in total

1.  Multiple sclerosis in Australia and New Zealand: are the determinants genetic or environmental?

Authors:  D H Miller; S R Hammond; J G McLeod; G Purdie; D C Skegg
Journal:  J Neurol Neurosurg Psychiatry       Date:  1990-10       Impact factor: 10.154

2.  Population frequency of HLA haplotypes contributes to the prevalence difference of multiple sclerosis in Ireland.

Authors:  Christopher McGuigan; Ciaran Dunne; John Crowley; Richard Hagan; Genevieve Rooney; Eimear Lawlor; Michael Hutchinson
Journal:  J Neurol       Date:  2005-09-16       Impact factor: 4.849

3.  Primarily chronic progressive and relapsing/remitting multiple sclerosis: two immunogenetically distinct disease entities.

Authors:  O Olerup; J Hillert; S Fredrikson; T Olsson; S Kam-Hansen; E Möller; B Carlsson; J Wallin
Journal:  Proc Natl Acad Sci U S A       Date:  1989-09       Impact factor: 11.205

4.  Class II HLA antigens in multiple sclerosis.

Authors:  D H Miller; R W Hornabrook; J Dagger; R Fong
Journal:  J Neurol Neurosurg Psychiatry       Date:  1989-05       Impact factor: 10.154

5.  The prevalence of multiple sclerosis in south east Wales.

Authors:  R J Swingler; D A Compston
Journal:  J Neurol Neurosurg Psychiatry       Date:  1988-12       Impact factor: 10.154

6.  Multiple sclerosis in the Cambridge health district of east Anglia.

Authors:  C J Mumford; M B Fraser; N W Wood; D A Compston
Journal:  J Neurol Neurosurg Psychiatry       Date:  1992-10       Impact factor: 10.154

7.  The epidemiology of multiple sclerosis in Devon: a comparison of the new and old classification criteria.

Authors:  C M Fox; S Bensa; I Bray; J P Zajicek
Journal:  J Neurol Neurosurg Psychiatry       Date:  2004-01       Impact factor: 10.154
  7 in total

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