Literature DB >> 3499275

Aberrant synthesis of antibodies directed at the Fab fragment of IgA in patients with IgA nephropathies.

S Jackson1, R I Montgomery, B A Julian, J H Galla, C Czerkinsky.   

Abstract

The sera of 37 patients with IgA nephropathy (IgA NP) were assayed for levels of antibodies specific for the Fab fragment of homologous IgA, and the values obtained were compared to antibody levels in a panel of 26 normal volunteers. IgG antibody levels in IgA NP patients were significantly elevated over those of the controls (P less than 0.01); at the same time IgM anti-Fab alpha levels were significantly decreased when compared to the control panel (P less than 0.01). There was no correlation of antibody levels of either isotype with levels of circulating immune complexes; however, IgM antibody levels of IgA NP patients showed a significant negative correlation with severity of renal insufficiency.

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Year:  1987        PMID： 3499275     DOI： 10.1016/0090-1229(87)90035-3

Source DB:  PubMed          Journal:  Clin Immunol Immunopathol        ISSN： 0090-1229


  9 in total

Review 1.  Progress in molecular and genetic studies of IgA nephropathy.

Authors:  J Novak; B A Julian; M Tomana; J Mesteck
Journal:  J Clin Immunol       Date:  2001-09       Impact factor: 8.317

2.  IgA-containing immune complexes after challenge with food antigens in patients with IgA nephropathy.

Authors:  S Jackson; Z Moldoveanu; K A Kirk; B A Julian; T F Patterson; A L Mullins; T Jilling; J Mestecky; J H Galla
Journal:  Clin Exp Immunol       Date:  1992-08       Impact factor: 4.330

3.  Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity.

Authors:  Hitoshi Suzuki; Run Fan; Zhixin Zhang; Rhubell Brown; Stacy Hall; Bruce A Julian; W Winn Chatham; Yusuke Suzuki; Robert J Wyatt; Zina Moldoveanu; Jeannette Y Lee; James Robinson; Milan Tomana; Yasuhiko Tomino; Jiri Mestecky; Jan Novak
Journal:  J Clin Invest       Date:  2009-05-26       Impact factor: 14.808

4.  Circulating immune complexes in IgA nephropathy consist of IgA1 with galactose-deficient hinge region and antiglycan antibodies.

Authors:  M Tomana; J Novak; B A Julian; K Matousovic; K Konecny; J Mestecky
Journal:  J Clin Invest       Date:  1999-07       Impact factor: 14.808

5.  Antibodies to polyclonal IgA, IgA1, and IgA2 and isotype-specific immune complexes in IgA nephropathy.

Authors:  C L Jones; C S Hosking; P Kincaid-Smith; H R Powell; S C Richardson; F H Sennhauser; D M Roberton
Journal:  J Clin Immunol       Date:  1989-07       Impact factor: 8.317

Review 6.  IgA nephropathy enigma.

Authors:  Jiri Mestecky; Jan Novak; Zina Moldoveanu; Milan Raska
Journal:  Clin Immunol       Date:  2016-07-18       Impact factor: 3.969

7.  Anti-immunoglobulin antibodies in children with Schönlein-Henoch syndrome. Absence of serum anti-IgA antibodies.

Authors:  A Blanco Quirós; C Blanco; J Alvarez; P Solis; F Conde; S Gomez
Journal:  Eur J Pediatr       Date:  1994-02       Impact factor: 3.183

Review 8.  IgA glycosylation and IgA immune complexes in the pathogenesis of IgA nephropathy.

Authors:  Jan Novak; Bruce A Julian; Milan Tomana; Jiri Mestecky
Journal:  Semin Nephrol       Date:  2008-01       Impact factor: 5.299

Review 9.  Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of IgA nephropathy.

Authors:  J Mestecky; M Tomana; Z Moldoveanu; B A Julian; H Suzuki; K Matousovic; M B Renfrow; L Novak; R J Wyatt; J Novak
Journal:  Kidney Blood Press Res       Date:  2008-01-08       Impact factor: 2.687
  9 in total

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