Literature DB >> 3499250

Single-dose kinetics of mefloquine in Brazilian male subjects.

J M de Souza, P Heizmann, D E Schwartz.   

Abstract

Ten male subjects from a region of the state of Pará, Brazil, where malaria is endemic received a single oral dose of 1000 mg mefloquine. The plasma levels of the drug and of its metabolite, 2,8-bis(trifluoromethyl)-4-quinolinecarboxylic acid, were determined densitometrically on thin-layer chromatography plates. The pharmacokinetic parameters obtained fell well within the range of values reported previously for Africans and Caucasians.

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Year:  1987        PMID： 3499250      PMCID： PMC2491007     

Source DB:  PubMed          Journal:  Bull World Health Organ        ISSN： 0042-9686            Impact factor:   9.408


  2 in total

1.  Single dose kinetics of mefloquine in man. Plasma levels of the unchanged drug and of one of its metabolites.

Authors:  D E Schwartz; G Eckert; D Hartmann; B Weber; D Richard-Lenoble; J M Ekue; M Gentilini
Journal:  Chemotherapy       Date:  1982       Impact factor: 2.544

2.  A phase I clinical trial of mefloquine in Brazilian male subjects.

Authors:  J M de Souza
Journal:  Bull World Health Organ       Date:  1983       Impact factor: 9.408
  2 in total
  8 in total

1.  Divided-dose kinetics of mefloquine in man.

Authors:  G Franssen; B Rouveix; J Lebras; J Bauchet; F Verdier; C Michon; F Bricaire
Journal:  Br J Clin Pharmacol       Date:  1989-08       Impact factor: 4.335

2.  Mefloquine antimalarial prophylaxis in pregnancy: dose finding and pharmacokinetic study.

Authors:  F Nosten; J Karbwang; N J White; K Na Bangchang; D Bunnag; T Harinasuta
Journal:  Br J Clin Pharmacol       Date:  1990-07       Impact factor: 4.335

Review 3.  Clinical pharmacokinetics of mefloquine.

Authors:  J Karbwang; N J White
Journal:  Clin Pharmacokinet       Date:  1990-10       Impact factor: 6.447

4.  Mefloquine therapy for Plasmodium falciparum malaria in children under 5 years of age in Malawi: in vivo/in vitro efficacy and correlation of drug concentration with parasitological outcome.

Authors:  L M Slutsker; C O Khoromana; D Payne; C R Allen; J J Wirima; D L Heymann; L Patchen; R W Steketee
Journal:  Bull World Health Organ       Date:  1990       Impact factor: 9.408

Review 5.  Treatment of malaria--1990.

Authors:  D M Panisko; J S Keystone
Journal:  Drugs       Date:  1990-02       Impact factor: 9.546

6.  Pharmacokinetics and pharmacodynamics of mefloquine in Thai patients with acute falciparum malaria.

Authors:  J Karbwang; K N Bangchang; D Bunnag; T Harinasuta
Journal:  Bull World Health Organ       Date:  1991       Impact factor: 9.408

Review 7.  The influence of pregnancy on the pharmacokinetic properties of artemisinin combination therapy (ACT): a systematic review.

Authors:  Renée J Burger; Benjamin J Visser; Martin P Grobusch; Michèle van Vugt
Journal:  Malar J       Date:  2016-02-18       Impact factor: 2.979

8.  Pharmacokinetics of mefloquine and its effect on sulfamethoxazole and trimethoprim steady-state blood levels in intermittent preventive treatment (IPTp) of pregnant HIV-infected women in Kenya.

Authors:  Michael Green; Kephas Otieno; Abraham Katana; Laurence Slutsker; Simon Kariuki; Peter Ouma; Raquel González; Clara Menendez; Feiko ter Kuile; Meghna Desai
Journal:  Malar J       Date:  2016-01-05       Impact factor: 2.979
  8 in total

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