Rahul Sharma1, Kanya Mukhopadhyay2, Amit Rawat1, Vanita Suri3, Surjit Singh1. 1. Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh. 2. Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh. Correspondence to: Prof Kanya Mukhopadhyay, Division of Neonatology, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh 160 012. kanyapgi@gmail.com. 3. Department of Obstetrics and Gynecology; Postgraduate Institute of Medical Education and Research, Chandigarh.
Abstract
OBJECTIVE: We documented the immunological profile of neonates and mothers, and lymphocyte subsets at birth. METHODS: Consecutively born preterm neonates (26 to 31 weeks gestation) at our level III neonatal unit, fulfilling the inclusion criteria were enrolled. Immunoglobulin levels were assessed in maternal blood and in cord blood along with T cell subsets. RESULTS: A total of 115 neonates were enrolled. The mean cord levels for IgG, IgM and IgA, respectively were 5.34, 0.10 and 0.04 g/L and of B, T, NK and NK-T cells were 14%, 71%, 10% and 1%, respectively of total lymphocyte population. Cord IgG and IgA levels showed a significantly rising trend with increasing gestation (P=0.005 and 0.02, respectively) but not IgM and T cell subsets. Maternal immunoglobulins were similar in all gestations. CONCLUSION: The cord IgG and IgA increased with increasing gestation but not IgM in neonates.
OBJECTIVE: We documented the immunological profile of neonates and mothers, and lymphocyte subsets at birth. METHODS: Consecutively born preterm neonates (26 to 31 weeks gestation) at our level III neonatal unit, fulfilling the inclusion criteria were enrolled. Immunoglobulin levels were assessed in maternal blood and in cord blood along with T cell subsets. RESULTS: A total of 115 neonates were enrolled. The mean cord levels for IgG, IgM and IgA, respectively were 5.34, 0.10 and 0.04 g/L and of B, T, NK and NK-T cells were 14%, 71%, 10% and 1%, respectively of total lymphocyte population. Cord IgG and IgA levels showed a significantly rising trend with increasing gestation (P=0.005 and 0.02, respectively) but not IgM and T cell subsets. Maternal immunoglobulins were similar in all gestations. CONCLUSION: The cord IgG and IgA increased with increasing gestation but not IgM in neonates.
Authors: C Quinello; A L Silveira-Lessa; M E J R Ceccon; M A Cianciarullo; M Carneiro-Sampaio; P Palmeira Journal: Scand J Immunol Date: 2014-07 Impact factor: 3.487
Authors: Konrad Bochennek; Esther Fryns; Boris Wittekindt; Horst Buxmann; Andrea Quaiser; Doris Fischer; Thomas Klingebiel; Ulrike Koehl; Rolf Schloesser; Sabine Huenecke Journal: Early Hum Dev Date: 2015-12-17 Impact factor: 2.079