Marisa Tucci1, Gemma Crighton2, Susan M Goobie3, Robert T Russell4, Robert I Parker5, Thorsten Haas6, Marianne E Nellis7, Adam M Vogel8, Jacques Lacroix9, Paul A Stricker10. 1. Department of Pediatrics, Sainte-Justine University Hospital, University of Montreal, Montreal, QC, Canada. 2. Department of Haematology, Royal Children's Hospital, Melbourne, VIC, Australia. 3. Department of Anesthesiology, Critical Care & Pain Medicine, Boston Children's Hospital, Boston, MA. 4. Department of Surgery, Division of Pediatric Surgery, Children's of Alabama, University of Alabama at Birmingham, Birmingham, AL. 5. Department of Pediatrics, Stony Brook University, Stony Brook, NY. 6. Department of Anesthesia, Zurich University Children's Hospital, Zurich, Switzerland. 7. Division of Pediatric Critical Care Medicine, Department of Pediatrics, NY Presbyterian Hospital - Weill Cornell Medicine, New York, NY. 8. Division of Pediatric Surgery, Surgery and Pediatrics Baylor College of Medicine Texas Children's Hospital, Houston, TX. 9. Department of Pediatrics, University of Montreal, Montreal, QC, Canada. 10. Department of Anesthesiology and Critical Care, The Children's Hospital of Philadelphia and the Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
Abstract
OBJECTIVES: To present consensus statements and supporting literature for plasma and platelet transfusions in critically ill children following noncardiac surgery and critically ill children undergoing invasive procedures outside the operating room from the Transfusion and Anemia EXpertise Initiative - Control/Avoidance of Bleeding. DESIGN: Systematic review and consensus conference of international, multidisciplinary experts in platelet and plasma transfusion management of critically ill children. SETTING: Not applicable. PATIENTS: Critically ill children undergoing invasive procedures outside of the operating room or noncardiac surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A panel of 10 experts developed evidence-based and, when evidence was insufficient, expert-based statements for plasma and platelet transfusions in critically ill children following noncardiac surgery or undergoing invasive procedures outside of the operating room. These statements were reviewed and ratified by the 29 Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding experts. A systematic review was conducted using MEDLINE, EMBASE, and Cochrane Library databases, from inception to December 2020. Consensus was obtained using the Research and Development/University of California, Los Angeles Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method. We developed eight expert consensus statements focused on the critically ill child following noncardiac surgery and 10 expert consensus statements on the critically ill child undergoing invasive procedures outside the operating room. CONCLUSIONS: Evidence regarding plasma and platelet transfusion in critically ill children in this area is very limited. The Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding Consensus Conference developed 18 pediatric specific consensus statements regarding plasma and platelet transfusion management in these critically ill pediatric populations.
OBJECTIVES: To present consensus statements and supporting literature for plasma and platelet transfusions in critically ill children following noncardiac surgery and critically ill children undergoing invasive procedures outside the operating room from the Transfusion and Anemia EXpertise Initiative - Control/Avoidance of Bleeding. DESIGN: Systematic review and consensus conference of international, multidisciplinary experts in platelet and plasma transfusion management of critically ill children. SETTING: Not applicable. PATIENTS: Critically ill children undergoing invasive procedures outside of the operating room or noncardiac surgery. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: A panel of 10 experts developed evidence-based and, when evidence was insufficient, expert-based statements for plasma and platelet transfusions in critically ill children following noncardiac surgery or undergoing invasive procedures outside of the operating room. These statements were reviewed and ratified by the 29 Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding experts. A systematic review was conducted using MEDLINE, EMBASE, and Cochrane Library databases, from inception to December 2020. Consensus was obtained using the Research and Development/University of California, Los Angeles Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method. We developed eight expert consensus statements focused on the critically ill child following noncardiac surgery and 10 expert consensus statements on the critically ill child undergoing invasive procedures outside the operating room. CONCLUSIONS: Evidence regarding plasma and platelet transfusion in critically ill children in this area is very limited. The Transfusion and Anemia EXpertise Initiative-Control/Avoidance of Bleeding Consensus Conference developed 18 pediatric specific consensus statements regarding plasma and platelet transfusion management in these critically ill pediatric populations.
Authors: Charles A Schiffer; Kari Bohlke; Meghan Delaney; Heather Hume; Anthony J Magdalinski; Jeffrey J McCullough; James L Omel; John M Rainey; Paolo Rebulla; Scott D Rowley; Michael B Troner; Kenneth C Anderson Journal: J Clin Oncol Date: 2017-11-28 Impact factor: 44.544
Authors: S M Goobie; D Zurakowski; K V Isaac; B M Taicher; P G Fernandez; C K Derderian; M Hetmaniuk; P A Stricker Journal: Br J Anaesth Date: 2018-12-19 Impact factor: 9.166
Authors: Scott C Howard; Amar J Gajjar; Cheng Cheng; Stephen B Kritchevsky; Grant W Somes; Patricia L Harrison; Raul C Ribeiro; Gaston K Rivera; Jeffrey E Rubnitz; John T Sandlund; Alberto J de Armendi; Bassem I Razzouk; Ching-Hon Pui Journal: JAMA Date: 2002 Oct 23-30 Impact factor: 56.272
Authors: Paul A Stricker; John E Fiadjoe; Amanda R Davis; Emily Sussman; Beverly J Burgess; Brian Ciampa; Jared Mendelsohn; Scott P Bartlett; Deborah A Sesok-Pizzini; David R Jobes Journal: Paediatr Anaesth Date: 2011-01 Impact factor: 2.556
Authors: Anthony D Slonim; Jill G Joseph; Wendy M Turenne; Aditi Sharangpani; Naomi L C Luban Journal: Transfusion Date: 2007-09-24 Impact factor: 3.157
Authors: Thanh T Nguyen; Sarah Hill; Thomas M Austin; Gina M Whitney; John C Wellons; Humphrey V Lam Journal: J Neurosurg Pediatr Date: 2015-07-31 Impact factor: 2.375
Authors: Marianne E Nellis; Oliver Karam; Stacey L Valentine; Scot T Bateman; Kenneth E Remy; Jacques Lacroix; Jill M Cholette; Melania M Bembea; Robert T Russell; Marie E Steiner; Susan M Goobie; Marisa Tucci; Paul A Stricker; Simon J Stanworth; Meghan Delaney; Lani Lieberman; Jennifer A Muszynski; David F Bauer; Katherine Steffen; Daniel Nishijima; Juan Ibla; Sitaram Emani; Adam M Vogel; Thorsten Haas; Ruchika Goel; Gemma Crighton; Diana Delgado; Michelle Demetres; Robert I Parker Journal: Pediatr Crit Care Med Date: 2022-01-01 Impact factor: 3.624