| Literature DB >> 3498743 |
M Bergström1, C Muhr, P O Lundberg, K Bergström, A D Gee, K J Fasth, B Långström.
Abstract
Four patients with prolactin-secreting pituitary adenomas were examined with positron emission tomography using L-[11C]methionine to monitor the effect of dopamine agonist treatment on the amino acid metabolism in the tumors. Within the first few hours after intramuscular injection of bromocriptine retard (50 mg) the amino acid metabolism decreased by 40%. Two of the patients were reexamined 7 and 9 days later and showed a 70% reduction in the metabolism of the adenomas. This metabolic effect was later accompanied by significant tumor shrinkage in all adenomas. It is suggested that bromocriptine has a general and rapid effect on the protein synthesis of the prolactin-secreting pituitary adenoma cells.Entities:
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Year: 1987 PMID： 3498743 DOI： 10.1097/00004728-198709000-00014
Source DB: PubMed Journal: J Comput Assist Tomogr ISSN： 0363-8715 Impact factor: 1.826