Literature DB >> 34987179

An update on male infertility and intratesticular testosterone-insight into novel serum biomarkers.

Karim Sidhom1, Kapilan Panchendrabose1, Uday Mann1,2, Premal Patel3,4.   

Abstract

Intratesticular testosterone is vital for spermatogenesis, male fertility, and virility. Currently the only method to assess levels of intratesticular testosterone is to perform testicular biopsy which is invasive and can lead to several complications. Approaches to assess intratesticular testosterone have been understudied but hold promise as future male contraceptive agents and may grant the ability to monitor patients undergoing hormonal changes from therapeutic and diagnostic perspectives. Previous studies have sought to assess the utility of 17-hydroxyprogesterone (17-OHP) and insulin-like factor 3 (INSL3) as accurate surrogate biomarkers of intratesticular testosterone. The aim of this review is thus to highlight the importance of intratesticular testosterone and the consequent advances that have been made to elucidate the potential of biomarkers for intratesticular testosterone in the context of male infertility.
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

Entities:  

Year:  2022        PMID： 34987179     DOI： 10.1038/s41443-021-00507-7

Source DB:  PubMed          Journal:  Int J Impot Res        ISSN： 0955-9930            Impact factor:   2.896


  46 in total

Review 1.  Hormonal regulation of spermatogenesis in primates and man: insights for development of the male hormonal contraceptive.

Authors:  Robert I McLachlan; Liza O'Donnell; Sarah J Meachem; Peter G Stanton; KretserDavidM de; Kryiakos Pratis; David M Robertson
Journal:  J Androl       Date:  2002 Mar-Apr

2.  The effect of a null mutation in the follicle-stimulating hormone receptor gene on mouse reproduction.

Authors:  M H Abel; A N Wootton; V Wilkins; I Huhtaniemi; P G Knight; H M Charlton
Journal:  Endocrinology       Date:  2000-05       Impact factor: 4.736

3.  Effect of seasonal changes in Leydig cell number on the volume of smooth endoplasmic reticulum in Leydig cells and intratesticular testosterone content in stallions.

Authors:  L Johnson; D L Thompson
Journal:  J Reprod Fertil       Date:  1987-09

4.  Serum inhibin B levels reflect Sertoli cell function in normal men and men with testicular dysfunction.

Authors:  B D Anawalt; R A Bebb; A M Matsumoto; N P Groome; P J Illingworth; A S McNeilly; W J Bremner
Journal:  J Clin Endocrinol Metab       Date:  1996-09       Impact factor: 5.958

5.  Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility.

Authors:  J S Tapanainen; K Aittomäki; J Min; T Vaskivuo; I T Huhtaniemi
Journal:  Nat Genet       Date:  1997-02       Impact factor: 38.330

Review 6.  Androgens and male fertility.

Authors:  G R Dohle; M Smit; R F A Weber
Journal:  World J Urol       Date:  2003-10-18       Impact factor: 4.226

7.  Stimulation of spermatogenesis by gonadotropins in men with hypogonadotropic hypogonadism.

Authors:  D M Finkel; J L Phillips; P J Snyder
Journal:  N Engl J Med       Date:  1985-09-12       Impact factor: 91.245

Review 8.  Approach to the infertile man.

Authors:  Shalender Bhasin
Journal:  J Clin Endocrinol Metab       Date:  2007-06       Impact factor: 5.958

9.  Impairing follicle-stimulating hormone (FSH) signaling in vivo: targeted disruption of the FSH receptor leads to aberrant gametogenesis and hormonal imbalance.

Authors:  A Dierich; M R Sairam; L Monaco; G M Fimia; A Gansmuller; M LeMeur; P Sassone-Corsi
Journal:  Proc Natl Acad Sci U S A       Date:  1998-11-10       Impact factor: 11.205

10.  Immunohistochemical localization of androgen receptors in the rat testis: evidence for stage-dependent expression and regulation by androgens.

Authors:  W J Bremner; M R Millar; R M Sharpe; P T Saunders
Journal:  Endocrinology       Date:  1994-09       Impact factor: 4.736
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