Literature DB >> 3498684

The effect of dexamethasone on growth and differentiation of bone-marrow derived mucosal mast cells in vitro.

C C McMenamin1, E A Gault, D M Haig.   

Abstract

An in vitro culture system was used to investigate the effects of dexamethasone on the production of mucosal mast cell (MMC) growth activity from T cells, and the proliferation and maturation of MMC in culture. The addition of dexamethasone (Dex) to cultures of lymphocytes from Nippostrongylus brasiliensis (Nb.)-infected rats suppressed production of MMC growth activity, as assessed by the lack of MMC growth and differentiation when supernatants of the treated lymphocyte cultures were added to normal rat bone-marrow cultures. Dexamethasone treatment of normal rat bone-marrow cultures affected the maturation of the bone-marrow derived MMC by preventing normal granule development. The ratio of neutrophils:macrophages present in the cultures was also altered. Dexamethasone did not have any detectable effect on mature MMC in culture.

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Year:  1987        PMID： 3498684      PMCID： PMC1453706     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  18 in total

1.  Glucocorticoid-induced inhibition of T cell growth factor production. II. The effect on the in vitro generation of cytolytic T cells.

Authors:  S Gillis; G R Crabtree; K A Smith
Journal:  J Immunol       Date:  1979-10       Impact factor: 5.422

Review 2.  Mechanisms of glucocorticoid action on immune processes.

Authors:  J E Parrillo; A S Fauci
Journal:  Annu Rev Pharmacol Toxicol       Date:  1979       Impact factor: 13.820

3.  The nature of the thymus dependency of mucosal mast cells. II. The effect of thymectomy and of depleting recirculating lymphocytes on the response to Nippostrongylus brasilliensis.

Authors:  G Mayrhofer
Journal:  Cell Immunol       Date:  1979-10       Impact factor: 4.868

4.  Immune reactions in mucous membranes. I. Intestinal mast cell response during helminth expulsion in the rat.

Authors:  H R Miller; W F Jarrett
Journal:  Immunology       Date:  1971-03       Impact factor: 7.397

5.  Glucocorticoid-induced inhibition of T cell growth factor production. I. The effect on mitogen-induced lymphocyte proliferation.

Authors:  S Gillis; G R Crabtree; K A Smith
Journal:  J Immunol       Date:  1979-10       Impact factor: 5.422

6.  Quantitative analysis of mucosal mast cell protease in the intestines of Nippostrongylus-infected rats.

Authors:  R G Woodbury; H R Miller
Journal:  Immunology       Date:  1982-07       Impact factor: 7.397

7.  Mechanisms of corticosteroid action on lymphocyte subpopulations. III. Differential effects of dexamethasone administration on subpopulations of effector cells mediating cellular cytotoxicity in man.

Authors:  J E Parrillo; A S Fauci
Journal:  Clin Exp Immunol       Date:  1978-01       Impact factor: 4.330

8.  Adoptive transfer of the intestinal mast cell response in rats infected with Nippostrongylus brasiliensis.

Authors:  Y Nawa; H R Miller
Journal:  Cell Immunol       Date:  1979-02       Impact factor: 4.868

9.  Phenotypic analysis of mast cell granule proteinases in normal rat bone marrow cultures.

Authors:  C McMenamin; D M Haig; S Gibson; G F Newlands; H R Miller
Journal:  Immunology       Date:  1987-01       Impact factor: 7.397

10.  Strongyloides ratti infections in rats. II. Effects of cortisone treatment.

Authors:  C E Olson; E L Schiller
Journal:  Am J Trop Med Hyg       Date:  1978-05       Impact factor: 2.345
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  7 in total

1.  Postnatal maturation of mast cell subpopulations in the rat respiratory tract.

Authors:  L K Wilkes; C McMenamin; P G Holt
Journal:  Immunology       Date:  1992-03       Impact factor: 7.397

2.  Role of T lymphocytes in intestinal mucosal injury. Inflammatory changes in athymic nude rats.

Authors:  R D'Inca; P Ernst; R H Hunt; M H Perdue
Journal:  Dig Dis Sci       Date:  1992-01       Impact factor: 3.199

3.  Rat bone marrow-derived mast cells co-cultured with 3T3 fibroblasts in the absence of T-cell derived cytokines require stem cell factor for their survival and maintain their mucosal mast cell-like phenotype.

Authors:  A J MacDonald; E M Thornton; G F Newlands; S J Galli; R Moqbel; H R Miller
Journal:  Immunology       Date:  1996-07       Impact factor: 7.397

4.  Heterogeneity of murine bone marrow-derived mast cells: analysis of their proteinase content.

Authors:  G F Newlands; D A Lammas; J F Huntley; A MacKellar; D Wakelin; H R Miller
Journal:  Immunology       Date:  1991-03       Impact factor: 7.397

5.  Immune responses to Trichinella spiralis and T. pseudospiralis in mice.

Authors:  D Wakelin; P K Goyal; M S Dehlawi; J Hermanek
Journal:  Immunology       Date:  1994-03       Impact factor: 7.397

6.  Dexamethasone induces a down regulation of rat mast cell protease II content in rat basophilic leukaemia cells.

Authors:  P R Saunders; J S Marshall
Journal:  Agents Actions       Date:  1992-05

7.  Dexamethasone inhibits the development of mast cells from dispersed human fetal liver cells cultured in the presence of recombinant human stem cell factor.

Authors:  A A Irani; G Nilsson; L K Ashman; L B Schwartz
Journal:  Immunology       Date:  1995-01       Impact factor: 7.397
  7 in total

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