Literature DB >> 34986527

The roles of epigenetic modifications in neurodegenerative diseases.

Wenzheng Qu1, Yingliang Zhuang1, Xuekun Li1.   

Abstract

In neuronal system, epigenetic modifications are essential for neuronal development, the fate determination of neural stem cells and neuronal function. The dysfunction of epigenetic regulation is closely related to occurrence and development of neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, Huntington's disease. Abnormally elevated DNA methylation inhibits the expression of some DNA repair-related genes and affects the progression of Huntington's disease. In the brain of Alzheimer's disease patients, the levels of H3K27ac and H3K9ac histone modifications increased. In addition, the alteration of RNA methylation in animal models of Alzheimer's disease and Parkinson's disease showed discrepancy trends. Therefore, epigenetic modifications may serve as potential therapeutic targets for neurodegenerative diseases. Here, we summarize the recent progress of the roles of epigenetic modifications in neurodegenerative diseases.

Entities:  

Keywords:  Alzheimer’s disease; DNA modification; Epigenetics; Histone modification; Huntington’s disease; Parkinson’s disease; RNA modification; Review

Mesh：

Year:  2021        PMID： 34986527      PMCID： PMC8732261          DOI： 10.3724/zdxbyxb-2021-0160

Source DB:  PubMed          Journal:  Zhejiang Da Xue Xue Bao Yi Xue Ban        ISSN： 1008-9292


  69 in total

Review 1.  The pivotal regulatory landscape of RNA modifications.

Authors:  Sheng Li; Christopher E Mason
Journal:  Annu Rev Genomics Hum Genet       Date:  2014-06-02       Impact factor: 8.929

2.  TET1 controls CNS 5-methylcytosine hydroxylation, active DNA demethylation, gene transcription, and memory formation.

Authors:  Garrett A Kaas; Chun Zhong; Dawn E Eason; Daniel L Ross; Raj V Vachhani; Guo-Li Ming; Jennifer R King; Hongjun Song; J David Sweatt
Journal:  Neuron       Date:  2013-09-18       Impact factor: 17.173

3.  5-methylcytosine and 5-hydroxymethylcytosine in brains of patients with multiple system atrophy and patients with Parkinson's disease.

Authors:  Oliver Kaut; Klaus Kuchelmeister; Christoph Moehl; Ullrich Wüllner
Journal:  J Chem Neuroanat       Date:  2018-12-14       Impact factor: 3.052

4.  TET2-mediated Cdkn2A DNA hydroxymethylation in midbrain dopaminergic neuron injury of Parkinson's disease.

Authors:  Ting-Ting Wu; Te Liu; Xuan Li; Ya-Jing Chen; Tian-Jiao Chen; Xiao-Ying Zhu; Jiu-Lin Chen; Qing Li; Ye Liu; Ya Feng; Yun-Cheng Wu
Journal:  Hum Mol Genet       Date:  2020-05-28       Impact factor: 6.150

5.  Regulation of Histone Acetylation by Autophagy in Parkinson Disease.

Authors:  Goonho Park; Jieqiong Tan; Guillermina Garcia; Yunyi Kang; Guy Salvesen; Zhuohua Zhang
Journal:  J Biol Chem       Date:  2015-12-23       Impact factor: 5.157

6.  Promoter Methylation and Gene Expression of Pin1 Associated with the Risk of Alzheimer's Disease in Southern Chinese.

Authors:  Suk L Ma; Nelson L S Tang; Linda C Wa Lam
Journal:  Curr Alzheimer Res       Date:  2020       Impact factor: 3.498

Review 7.  The RNA Modification N6-methyladenosine and Its Implications in Human Disease.

Authors:  Pedro J Batista
Journal:  Genomics Proteomics Bioinformatics       Date:  2017-05-19       Impact factor: 7.691

8.  A histone acetylome-wide association study of Alzheimer's disease identifies disease-associated H3K27ac differences in the entorhinal cortex.

Authors:  Sarah J Marzi; Szi Kay Leung; Teodora Ribarska; Eilis Hannon; Adam R Smith; Ehsan Pishva; Jeremie Poschmann; Karen Moore; Claire Troakes; Safa Al-Sarraj; Stephan Beck; Stuart Newman; Katie Lunnon; Leonard C Schalkwyk; Jonathan Mill
Journal:  Nat Neurosci       Date:  2018-10-22       Impact factor: 24.884

9.  Inhibition of HDAC3 reverses Alzheimer's disease-related pathologies in vitro and in the 3xTg-AD mouse model.

Authors:  Karolina J Janczura; Claude-Henry Volmar; Gregory C Sartor; Sunil J Rao; Natalie R Ricciardi; Guerline Lambert; Shaun P Brothers; Claes Wahlestedt
Journal:  Proc Natl Acad Sci U S A       Date:  2018-11-05       Impact factor: 11.205

10.  Topology of the human and mouse m6A RNA methylomes revealed by m6A-seq.

Authors:  Dan Dominissini; Sharon Moshitch-Moshkovitz; Schraga Schwartz; Mali Salmon-Divon; Lior Ungar; Sivan Osenberg; Karen Cesarkas; Jasmine Jacob-Hirsch; Ninette Amariglio; Martin Kupiec; Rotem Sorek; Gideon Rechavi
Journal:  Nature       Date:  2012-04-29       Impact factor: 49.962
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