Lee Smith1, Hans Oh2, Louis Jacob3,4,5, Guillermo F López-Sánchez6, Nicola Veronese7, Pinar Soysal8, Jae Il Shin9, Felipe Schuch10, Mark A Tully11, Laurie Butler1, Yvonne Barnett1, Ai Koyanagi3,4,12. 1. Centre for Health, Performance and Wellbeing, Anglia Ruskin University, Cambridge, CB1 1PT, UK. 2. Suzanne Dworak-Peck School of Social Work, University of Southern California, Los Angeles, CA, USA. 3. Research and Development Unit, Parc Sanitari Sant Joan de Déu, Dr. Antoni Pujadas, 42, 08830, Sant Boi de Llobregat, Barcelona, Spain. 4. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain. 5. Faculty of Medicine, University of Versailles Saint-Quentin-en-Yvelines, 78180, Montigny-le-Bretonneux, France. 6. Division of Preventive Medicine and Public Health, Department of Public Health Sciences, School of Medicine, University of Murcia, 30100, Espinardo, Murcia, Spain. gfls@um.es. 7. Department of Internal Medicine, Geriatrics Section, University of Palermo, Palermo, Italy. 8. Department of Geriatric Medicine, Faculty of Medicine, Bezmialem Vakif University, Adnan Menderes Bulvarı (Vatan Street), Fatih, 34093, İstanbul, Turkey. 9. Department of Pediatrics, Yonsei University College of Medicine, Seoul, South Korea. 10. Department of Sports Methods and Techniques, Federal University of Santa Maria, Santa Maria, Brazil. 11. School of Health Sciences, Institute of Mental Health Sciences, Ulster University, Newtownabbey, BT37 0QB, Northern Ireland, UK. 12. ICREA, Pg. Lluis Companys 23, 08010, Barcelona, Spain.
Abstract
BACKGROUND: Currently, a small body of evidence suggests that sleep problems are positively associated with subjective cognitive complaints (SCC). However, no studies on this topic exist from low- and middle-income countries (LMICs). Thus, we investigated the association between sleep problems and SCC in a large sample of middle-age and older adults from 45 LMICs. METHODS: Cross-sectional, predominantly nationally representative, community-based data were analyzed from the World Health Survey. Sleep problems (such as difficulties falling asleep, waking up frequently during the night or waking up too early in the morning) in the last 30 days were self-reported. Two questions on subjective memory and learning complaints in the past 30 days were used to create a SCC scale ranging from 0 (No SCC) to 100 (worse SCC). Multivariable linear regression was conducted to explore the association between sleep problems (exposure) and SCC (outcome). RESULTS: Data on 60,228 adults aged ≥ 50 years were analyzed [mean (SD) age 61.4 (9.9) years; 53.9% females]. After adjustment for potential confounders, compared to those without sleep problems, the mean SCC score for the multivariable model was 13.32 (95% CI 12.01, 14.63), 19.46 (95% CI 17.95, 20.98), 24.17 (95% CI 22.02, 26.33), and 31.39 (95% CI 28.13, 34.65) points higher for mild, moderate, severe, and extreme sleep problems, respectively. Similar results were found for analyses stratified by age and country-income level. CONCLUSION: Sleep problems were positively associated in a dose-response manner with SCC among middle-aged and older adults in multiple LMICs. Addressing sleep problems may aid in the prevention of SCC and ultimately dementia, pending future longitudinal research.
BACKGROUND: Currently, a small body of evidence suggests that sleep problems are positively associated with subjective cognitive complaints (SCC). However, no studies on this topic exist from low- and middle-income countries (LMICs). Thus, we investigated the association between sleep problems and SCC in a large sample of middle-age and older adults from 45 LMICs. METHODS: Cross-sectional, predominantly nationally representative, community-based data were analyzed from the World Health Survey. Sleep problems (such as difficulties falling asleep, waking up frequently during the night or waking up too early in the morning) in the last 30 days were self-reported. Two questions on subjective memory and learning complaints in the past 30 days were used to create a SCC scale ranging from 0 (No SCC) to 100 (worse SCC). Multivariable linear regression was conducted to explore the association between sleep problems (exposure) and SCC (outcome). RESULTS: Data on 60,228 adults aged ≥ 50 years were analyzed [mean (SD) age 61.4 (9.9) years; 53.9% females]. After adjustment for potential confounders, compared to those without sleep problems, the mean SCC score for the multivariable model was 13.32 (95% CI 12.01, 14.63), 19.46 (95% CI 17.95, 20.98), 24.17 (95% CI 22.02, 26.33), and 31.39 (95% CI 28.13, 34.65) points higher for mild, moderate, severe, and extreme sleep problems, respectively. Similar results were found for analyses stratified by age and country-income level. CONCLUSION: Sleep problems were positively associated in a dose-response manner with SCC among middle-aged and older adults in multiple LMICs. Addressing sleep problems may aid in the prevention of SCC and ultimately dementia, pending future longitudinal research.
Authors: Ryan Van Patten; Tanya T Nguyen; Zanjbeel Mahmood; Ellen E Lee; Rebecca E Daly; Barton W Palmer; Tsung-Chin Wu; Xin Tu; Dilip V Jeste; Elizabeth W Twamley Journal: Int J Aging Hum Dev Date: 2021-07-01