Literature DB >> 34985664

Ex Vivo HIV Infection Model of Cervico-Vaginal and Rectal Tissue.

Louise A Ouattara1, Nikolas C Vann2, Gustavo F Doncel2.   

Abstract

Globally, the most frequent route of HIV transmission is through sexual intercourse. In women, sexual transmission of HIV involves cervical, vaginal, endometrial, and rectal mucosal exposure to the virus. Here we describe technical protocols for ex vivo cervical, vaginal, and rectal tissue infection models and cultures that can be used to assess tissue susceptibility to infection under different conditions as well as the potential antiviral efficacy of a treatment for HIV prevention or cure.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  Biopsies; Cervicovaginal; Explants; HIV; HIV endpoints; Immersion model; Polarized model; Rectal

Mesh：

Year:  2022        PMID： 34985664     DOI： 10.1007/978-1-0716-1871-4_12

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  29 in total

Review 1.  Transmission, acute HIV-1 infection and the quest for strategies to prevent infection.

Authors:  Melissa Pope; Ashley T Haase
Journal:  Nat Med       Date:  2003-07       Impact factor: 53.440

Review 2.  Early events in sexual transmission of HIV and SIV and opportunities for interventions.

Authors:  Ashley T Haase
Journal:  Annu Rev Med       Date:  2011       Impact factor: 13.739

Review 3.  HIV infection of the genital mucosa in women.

Authors:  Florian Hladik; Thomas J Hope
Journal:  Curr HIV/AIDS Rep       Date:  2009-02       Impact factor: 5.071

Review 4.  Animal models of antiretroviral prophylaxis for HIV prevention.

Authors:  J Gerardo García-Lerma; Walid Heneine
Journal:  Curr Opin HIV AIDS       Date:  2012-11       Impact factor: 4.283

Review 5.  Setting the stage: host invasion by HIV.

Authors:  Florian Hladik; M Juliana McElrath
Journal:  Nat Rev Immunol       Date:  2008-06       Impact factor: 53.106

6.  Preventing sexual transmission of HIV.

Authors:  Myron S Cohen
Journal:  Clin Infect Dis       Date:  2007-12-15       Impact factor: 9.079

7.  HIV-1 infection of female genital tract tissue for use in prevention studies.

Authors:  Charlene S Dezzutti; Kevin Uranker; Katherine E Bunge; Nicola Richardson-Harman; Ingrid Macio; Sharon L Hillier
Journal:  J Acquir Immune Defic Syndr       Date:  2013-08-15       Impact factor: 3.731

8.  Th17 Cells Are Preferentially Infected Very Early after Vaginal Transmission of SIV in Macaques.

Authors:  Daniel J Stieh; Edgar Matias; Huanbin Xu; Angela J Fought; James L Blanchard; Preston A Marx; Ronald S Veazey; Thomas J Hope
Journal:  Cell Host Microbe       Date:  2016-04-13       Impact factor: 21.023

9.  Ex vivo culture of human colorectal tissue for the evaluation of candidate microbicides.

Authors:  Patricia S Fletcher; Julie Elliott; Jean-Charles Grivel; Leonid Margolis; Peter Anton; Ian McGowan; Robin J Shattock
Journal:  AIDS       Date:  2006-06-12       Impact factor: 4.177

Review 10.  Mucosa: Key Interactions Determining Sexual Transmission of the HIV Infection.

Authors:  Sandra M Gonzalez; Wbeimar Aguilar-Jimenez; Ruey-Chyi Su; Maria T Rugeles
Journal:  Front Immunol       Date:  2019-02-06       Impact factor: 7.561
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  1 in total

1.  Vaginal Microbiota and Mucosal Pharmacokinetics of Tenofovir in Healthy Women Using a 90-Day Tenofovir/Levonorgestrel Vaginal Ring.

Authors:  Andrea R Thurman; Jacques Ravel; Pawel Gajer; Mark A Marzinke; Louise A Ouattara; Terry Jacot; M Melissa Peet; Meredith R Clark; Gustavo F Doncel
Journal:  Front Cell Infect Microbiol       Date:  2022-03-08       Impact factor: 5.293
  1 in total

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