Literature DB >> 34985663

Hematopoietic Stem and Progenitor Cells (HSPCs).

Valeri H Terry1, Gretchen E Zimmerman1, Maria C Virgilio2,3, Mark M Painter4, Dale Bixby1, Kathleen L Collins5,6.   

Abstract

Cord blood is a readily available source of hematopoietic stem and progenitor cells (HSPCs) which can be infected with HIV-1 in vitro to produce inducible latently infected cells for reactivation studies. Infected HSPCs can also be found in the setting of clinically undetectable viremia in vivo. Here we describe an in vitro infection model utilizing cord blood derived HSPCs, as well as methods for isolating and characterizing provirus from bone marrow HSPCs from suppressed patients.
© 2022. Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  HIV-1; HSPC; Latency; Reactivation; Reservoir

Mesh：

Year:  2022        PMID： 34985663     DOI： 10.1007/978-1-0716-1871-4_11

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  12 in total

1.  CD133+ hematopoietic progenitor cells harbor HIV genomes in a subset of optimally treated people with long-term viral suppression.

Authors:  Lucy A McNamara; Adewunmi Onafuwa-Nuga; Nadia T Sebastian; James Riddell; Dale Bixby; Kathleen L Collins
Journal:  J Infect Dis       Date:  2013-04-03       Impact factor: 5.226

2.  Class 1-Selective Histone Deacetylase (HDAC) Inhibitors Enhance HIV Latency Reversal while Preserving the Activity of HDAC Isoforms Necessary for Maximal HIV Gene Expression.

Authors:  Thomas D Zaikos; Mark M Painter; Nadia T Sebastian Kettinger; Valeri H Terry; Kathleen L Collins
Journal:  J Virol       Date:  2018-02-26       Impact factor: 5.103

3.  Latent HIV-1 infection occurs in multiple subsets of hematopoietic progenitor cells and is reversed by NF-κB activation.

Authors:  Lucy A McNamara; Janani A Ganesh; Kathleen L Collins
Journal:  J Virol       Date:  2012-06-20       Impact factor: 5.103

4.  HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

Authors:  K L Collins; B K Chen; S A Kalams; B D Walker; D Baltimore
Journal:  Nature       Date:  1998-01-22       Impact factor: 49.962

5.  HIV-1 utilizes the CXCR4 chemokine receptor to infect multipotent hematopoietic stem and progenitor cells.

Authors:  Christoph C Carter; Lucy A McNamara; Adewunmi Onafuwa-Nuga; Mark Shackleton; James Riddell; Dale Bixby; Michael R Savona; Sean J Morrison; Kathleen L Collins
Journal:  Cell Host Microbe       Date:  2011-03-17       Impact factor: 21.023

6.  HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs.

Authors:  Christoph C Carter; Adewunmi Onafuwa-Nuga; Lucy A McNamara; James Riddell; Dale Bixby; Michael R Savona; Kathleen L Collins
Journal:  Nat Med       Date:  2010-03-07       Impact factor: 53.440

7.  Infection of hematopoietic progenitor cells by HIV-1 subtype C, and its association with anemia in southern Africa.

Authors:  Andrew D Redd; Ava Avalos; Max Essex
Journal:  Blood       Date:  2007-08-10       Impact factor: 22.113

8.  Hematopoietic Stem and Progenitor Cells Are a Distinct HIV Reservoir that Contributes to Persistent Viremia in Suppressed Patients.

Authors:  Thomas D Zaikos; Valeri H Terry; Nadia T Sebastian Kettinger; Jay Lubow; Mark M Painter; Maria C Virgilio; Andrew Neevel; Frances Taschuk; Adewunmi Onafuwa-Nuga; Lucy A McNamara; James Riddell; Dale Bixby; Norman Markowitz; Kathleen L Collins
Journal:  Cell Rep       Date:  2018-12-26       Impact factor: 9.423

9.  Quiescence Promotes Latent HIV Infection and Resistance to Reactivation from Latency with Histone Deacetylase Inhibitors.

Authors:  Mark M Painter; Thomas D Zaikos; Kathleen L Collins
Journal:  J Virol       Date:  2017-11-30       Impact factor: 5.103

10.  CD4 is expressed on a heterogeneous subset of hematopoietic progenitors, which persistently harbor CXCR4 and CCR5-tropic HIV proviral genomes in vivo.

Authors:  Nadia T Sebastian; Thomas D Zaikos; Valeri Terry; Frances Taschuk; Lucy A McNamara; Adewunmi Onafuwa-Nuga; Ryan Yucha; Robert A J Signer; James Riddell; Dale Bixby; Norman Markowitz; Sean J Morrison; Kathleen L Collins
Journal:  PLoS Pathog       Date:  2017-07-21       Impact factor: 6.823
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