Literature DB >> 34984451

Potential of Stem Cell-Based Therapy to Restore Function in Aging Systems: Are We There Yet?

Joshua M Hare1, Isabel Beerman2.   

Abstract

While there is extensive interest in geroscience approaches to health and disease, few basic science discoveries have made their way into clinical trials. Herein, we comment on cell-based therapies, in which supplementing robust stem cell capacity to aged systems theoretically could lead to sustained improvement. This exciting approach has undergone translational development, and we highlight studies targeting a single system and others aimed at treating overall aging frailty by restoring the aged stem cell niches that underly diminished endogenous regenerative capacity. Published by Oxford University Press on behalf of The Gerontological Society of America 2022.

Entities:  

Keywords:  Aging; Clinical trials; Intervention; Rejuvenation; Stem cells

Mesh：

Year:  2022        PMID： 34984451      PMCID： PMC9255684          DOI： 10.1093/gerona/glac003

Source DB:  PubMed          Journal:  J Gerontol A Biol Sci Med Sci        ISSN： 1079-5006            Impact factor:   6.591


  19 in total

1.  The origin and evolution of mutations in acute myeloid leukemia.

Authors:  John S Welch; Timothy J Ley; Daniel C Link; Christopher A Miller; David E Larson; Daniel C Koboldt; Lukas D Wartman; Tamara L Lamprecht; Fulu Liu; Jun Xia; Cyriac Kandoth; Robert S Fulton; Michael D McLellan; David J Dooling; John W Wallis; Ken Chen; Christopher C Harris; Heather K Schmidt; Joelle M Kalicki-Veizer; Charles Lu; Qunyuan Zhang; Ling Lin; Michelle D O'Laughlin; Joshua F McMichael; Kim D Delehaunty; Lucinda A Fulton; Vincent J Magrini; Sean D McGrath; Ryan T Demeter; Tammi L Vickery; Jasreet Hundal; Lisa L Cook; Gary W Swift; Jerry P Reed; Patricia A Alldredge; Todd N Wylie; Jason R Walker; Mark A Watson; Sharon E Heath; William D Shannon; Nobish Varghese; Rakesh Nagarajan; Jacqueline E Payton; Jack D Baty; Shashikant Kulkarni; Jeffery M Klco; Michael H Tomasson; Peter Westervelt; Matthew J Walter; Timothy A Graubert; John F DiPersio; Li Ding; Elaine R Mardis; Richard K Wilson
Journal:  Cell       Date:  2012-07-20       Impact factor: 41.582

2.  The Design and Rationale of a Phase 2b, Randomized, Double-Blinded, and Placebo-Controlled Trial to Evaluate the Safety and Efficacy of Lomecel-B in Older Adults with Frailty.

Authors:  K Yousefi; K N Ramdas; J G Ruiz; J Walston; H Arai; E Volpi; A B Newman; C Wang; B Hitchinson; L McClain-Moss; L Diaz; G A Green; J M Hare; A A Oliva
Journal:  J Frailty Aging       Date:  2022

Review 3.  The hallmarks of aging.

Authors:  Carlos López-Otín; Maria A Blasco; Linda Partridge; Manuel Serrano; Guido Kroemer
Journal:  Cell       Date:  2013-06-06       Impact factor: 41.582

Review 4.  The ins and outs of muscle stem cell aging.

Authors:  Andrew S Brack; Pura Muñoz-Cánoves
Journal:  Skelet Muscle       Date:  2016-01-18       Impact factor: 4.912

5.  Long-term moderate calorie restriction inhibits inflammation without impairing cell-mediated immunity: a randomized controlled trial in non-obese humans.

Authors:  Simin N Meydani; Sai K Das; Carl F Pieper; Michael R Lewis; Sam Klein; Vishwa D Dixit; Alok K Gupta; Dennis T Villareal; Manjushri Bhapkar; Megan Huang; Paul J Fuss; Susan B Roberts; John O Holloszy; Luigi Fontana
Journal:  Aging (Albany NY)       Date:  2016-07       Impact factor: 5.682

6.  Allogeneic Human Mesenchymal Stem Cell Infusions for Aging Frailty.

Authors:  Samuel Golpanian; Darcy L DiFede; Aisha Khan; Ivonne Hernandez Schulman; Ana Marie Landin; Bryon A Tompkins; Alan W Heldman; Roberto Miki; Bradley J Goldstein; Muzammil Mushtaq; Silvina Levis-Dusseau; John J Byrnes; Maureen Lowery; Makoto Natsumeda; Cindy Delgado; Russell Saltzman; Mayra Vidro-Casiano; Marietsy V Pujol; Moisaniel Da Fonseca; Anthony A Oliva; Geoff Green; Courtney Premer; Audrey Medina; Krystalenia Valasaki; Victoria Florea; Erica Anderson; Jill El-Khorazaty; Adam Mendizabal; Pascal J Goldschmidt-Clermont; Joshua M Hare
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2017-10-12       Impact factor: 6.053

7.  Nicotinamide Riboside Augments the Aged Human Skeletal Muscle NAD+ Metabolome and Induces Transcriptomic and Anti-inflammatory Signatures.

Authors:  Yasir S Elhassan; Katarina Kluckova; Rachel S Fletcher; Mark S Schmidt; Antje Garten; Craig L Doig; David M Cartwright; Lucy Oakey; Claire V Burley; Ned Jenkinson; Martin Wilson; Samuel J E Lucas; Ildem Akerman; Alex Seabright; Yu-Chiang Lai; Daniel A Tennant; Peter Nightingale; Gareth A Wallis; Konstantinos N Manolopoulos; Charles Brenner; Andrew Philp; Gareth G Lavery
Journal:  Cell Rep       Date:  2019-08-13       Impact factor: 9.423

Review 8.  Recent advances on skin-resident stem/progenitor cell functions in skin regeneration, aging and cancers and novel anti-aging and cancer therapies.

Authors:  Murielle Mimeault; Surinder K Batra
Journal:  J Cell Mol Med       Date:  2009-09-01       Impact factor: 5.310

9.  Senolytics prevent mt-DNA-induced inflammation and promote the survival of aged organs following transplantation.

Authors:  Jasper Iske; Midas Seyda; Timm Heinbokel; Ryoichi Maenosono; Koichiro Minami; Yeqi Nian; Markus Quante; Christine S Falk; Haruhito Azuma; Friederike Martin; João F Passos; Claus U Niemann; Tamara Tchkonia; James L Kirkland; Abdallah Elkhal; Stefan G Tullius
Journal:  Nat Commun       Date:  2020-08-27       Impact factor: 14.919

10.  Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial.

Authors:  Bryon A Tompkins; Darcy L DiFede; Aisha Khan; Ana Marie Landin; Ivonne Hernandez Schulman; Marietsy V Pujol; Alan W Heldman; Roberto Miki; Pascal J Goldschmidt-Clermont; Bradley J Goldstein; Muzammil Mushtaq; Silvina Levis-Dusseau; John J Byrnes; Maureen Lowery; Makoto Natsumeda; Cindy Delgado; Russell Saltzman; Mayra Vidro-Casiano; Moisaniel Da Fonseca; Samuel Golpanian; Courtney Premer; Audrey Medina; Krystalenia Valasaki; Victoria Florea; Erica Anderson; Jill El-Khorazaty; Adam Mendizabal; Geoff Green; Anthony A Oliva; Joshua M Hare
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2017-10-12       Impact factor: 6.053
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