Literature DB >> 34982577

The PIKK-AKT connection in the DNA damage response.

Sejeong Shin1, Katherine A Walker1, Sang-Oh Yoon1.   

Abstract

DNA damage and subsequent cellular response are the basis for many cancer treatments. In this issue of Science Signaling, Liu et al. elucidate a mechanism by which cancer cells survive DNA damage induced by radiation and chemotherapy.

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Year:  2022        PMID： 34982577      PMCID： PMC8860323          DOI： 10.1126/scisignal.abm6211

Source DB:  PubMed          Journal:  Sci Signal        ISSN： 1945-0877            Impact factor:   9.517


  10 in total

Review 1.  Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?

Authors:  Dominico Vigil; Jacqueline Cherfils; Kent L Rossman; Channing J Der
Journal:  Nat Rev Cancer       Date:  2010-11-24       Impact factor: 60.716

Review 2.  Targeting the DNA damage response in immuno-oncology: developments and opportunities.

Authors:  Roman M Chabanon; Mathieu Rouanne; Christopher J Lord; Jean-Charles Soria; Philippe Pasero; Sophie Postel-Vinay
Journal:  Nat Rev Cancer       Date:  2021-08-10       Impact factor: 60.716

Review 3.  Molecular mechanisms involved in DNA repair in human cancers: An overview of PI3k/Akt signaling and PIKKs crosstalk.

Authors:  Forough Alemi; Aydin Raei Sadigh; Faezeh Malakoti; Yusuf Elhaei; Seyed Hamed Ghaffari; Masomeh Maleki; Zatollah Asemi; Bahman Yousefi; Niloufar Targhazeh; Maryam Majidinia
Journal:  J Cell Physiol       Date:  2021-09-13       Impact factor: 6.384

4.  DNA-PK promotes activation of the survival kinase AKT in response to DNA damage through an mTORC2-ECT2 pathway.

Authors:  Liu Liu; Xiaoming Dai; Shasha Yin; Pengda Liu; Elizabeth G Hill; Wenyi Wei; Wenjian Gan
Journal:  Sci Signal       Date:  2022-01-04       Impact factor: 9.517

Review 5.  AKT/PKB Signaling: Navigating the Network.

Authors:  Brendan D Manning; Alex Toker
Journal:  Cell       Date:  2017-04-20       Impact factor: 41.582

Review 6.  State-of-the-art strategies for targeting the DNA damage response in cancer.

Authors:  Patrick G Pilié; Chad Tang; Gordon B Mills; Timothy A Yap
Journal:  Nat Rev Clin Oncol       Date:  2019-02       Impact factor: 66.675

Review 7.  Targeting the DNA Damage Response in Cancer.

Authors:  Mark J O'Connor
Journal:  Mol Cell       Date:  2015-11-19       Impact factor: 17.970

Review 8.  mTOR at the nexus of nutrition, growth, ageing and disease.

Authors:  Grace Y Liu; David M Sabatini
Journal:  Nat Rev Mol Cell Biol       Date:  2020-01-14       Impact factor: 94.444

Review 9.  Akt-ing Up Just About Everywhere: Compartment-Specific Akt Activation and Function in Receptor Tyrosine Kinase Signaling.

Authors:  Michael G Sugiyama; Gregory D Fairn; Costin N Antonescu
Journal:  Front Cell Dev Biol       Date:  2019-05-03

10.  The dynamic behavior of Ect2 in response to DNA damage.

Authors:  Dan He; Jinnan Xiang; Baojie Li; Huijuan Liu
Journal:  Sci Rep       Date:  2016-04-14       Impact factor: 4.379
  10 in total

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