| Literature DB >> 34982351 |
Erino Araki1,2, Masaya Hane1,2,3, Rina Hatanaka1,2, Ryota Kimura1,2, Kana Tsuda1,2, Miku Konishi4, Naoko Komura4, Hiromune Ando4, Ken Kitajima1,2,3, Chihiro Sato5,6,7.
Abstract
Gangliosides are important components of the membrane and are involved in many biological activities. St8sia5 is an α2,8-sialyltransferase involved in ganglioside synthesis, and has three isoforms. In this study, we analyzed the features of three isoforms, St8sia5-S, -M, and -L that had not been analyzed, and found that only St8sia5-L was localized in the Golgi, while the majority of St8sia5-M and -S were localized in the ER. The localization of Golgi of St8sia5 depended on the stem region. In addition, the incorporation of exogenous GD3 was upregulated only in St8sia5-L expressing cells. Taken together, the localization of St8sia5 is important for the activity of the enzyme.Entities:
Keywords: Ganglioside, isoform; Melanoma; Sialic acid; Sialyltransferase
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Year: 2022 PMID： 34982351 DOI： 10.1007/s10719-021-10034-8
Source DB: PubMed Journal: Glycoconj J ISSN： 0282-0080 Impact factor: 2.916