Peng Cao1, Chen Zhang1, Dong-Xu Hua1, Meng-Die Li1, Bian-Bian Lv1, Lin Fu2, Hui Zhao3. 1. Second Affiliated Hospital, Anhui Medical University, Furong Road no 678, Hefei, 230601, China. 2. Second Affiliated Hospital, Anhui Medical University, Furong Road no 678, Hefei, 230601, China. fulindev@126.com. 3. Second Affiliated Hospital, Anhui Medical University, Furong Road no 678, Hefei, 230601, China. zhaohuichenxi@126.com.
Abstract
BACKGROUND: Oxidative stress is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). 8-Hydroxy-2'-deoxyguanosine (8-OHdG) is recognized as a biomarker of oxidative stress and is implicated in several pulmonary diseases. Nonetheless, the role of 8-OHdG remains unclear in COPD patients. This research aimed to evaluate the correlations between serum 8-OHdG on admission and the severity and prognosis of hospitalized COPD patients with acute exacerbation. METHODS: A total of 150 COPD hospitalized patients and 150 healthy individuals were recruited. Serum 8-OHdG was measured by ELISA and the length of hospital stay was calculated. The number of acute exacerbations of COPD was tracked within 1 year after this hospitalization. RESULTS: The levels of serum 8-OHdG were elevated in COPD patients compared with the control group. Serum 8-OHdG was gradually elevated with decreased pulmonary function in COPD patients. Furthermore, Pearson linear association found that the levels of serum 8-OHdG were inversely correlated with pulmonary function and positively correlated with inflammatory cytokines in COPD patients. In addition, logistic regression analysis revealed that serum 8-OHdG elevation was a risk factor for pulmonary function decline in COPD patients. The length of hospital stay was tracked at this time. Higher serum 8-OHdG on admission increased the length of hospital stay among COPD patients. CONCLUSION: Serum 8-OHdG on admission is positively correlated with the severity and adverse prognosis among COPD patients, suggesting that 8-OHdG may be involved in the pathogenesis of COPD. Serum 8-OHdG may be a biomarker to predict the progression of COPD.
BACKGROUND: Oxidative stress is involved in the pathogenesis of chronic obstructive pulmonary disease (COPD). 8-Hydroxy-2'-deoxyguanosine (8-OHdG) is recognized as a biomarker of oxidative stress and is implicated in several pulmonary diseases. Nonetheless, the role of 8-OHdG remains unclear in COPD patients. This research aimed to evaluate the correlations between serum 8-OHdG on admission and the severity and prognosis of hospitalized COPD patients with acute exacerbation. METHODS: A total of 150 COPD hospitalized patients and 150 healthy individuals were recruited. Serum 8-OHdG was measured by ELISA and the length of hospital stay was calculated. The number of acute exacerbations of COPD was tracked within 1 year after this hospitalization. RESULTS: The levels of serum 8-OHdG were elevated in COPD patients compared with the control group. Serum 8-OHdG was gradually elevated with decreased pulmonary function in COPD patients. Furthermore, Pearson linear association found that the levels of serum 8-OHdG were inversely correlated with pulmonary function and positively correlated with inflammatory cytokines in COPD patients. In addition, logistic regression analysis revealed that serum 8-OHdG elevation was a risk factor for pulmonary function decline in COPD patients. The length of hospital stay was tracked at this time. Higher serum 8-OHdG on admission increased the length of hospital stay among COPD patients. CONCLUSION: Serum 8-OHdG on admission is positively correlated with the severity and adverse prognosis among COPD patients, suggesting that 8-OHdG may be involved in the pathogenesis of COPD. Serum 8-OHdG may be a biomarker to predict the progression of COPD.
Authors: Ylermi Soini; Kirsi-Maria Haapasaari; Markku H Vaarala; Taina Turpeenniemi-Hujanen; V Kärjä; Peeter Karihtala Journal: Int J Clin Exp Pathol Date: 2011-03-02
Authors: Claus F Vogelmeier; Gerard J Criner; Fernando J Martínez; Antonio Anzueto; Peter J Barnes; Jean Bourbeau; Bartolome R Celli; Rongchang Chen; Marc Decramer; Leonardo M Fabbri; Peter Frith; David M G Halpin; M Victorina López Varela; Masaharu Nishimura; Nicolás Roche; Roberto Rodríguez-Roisin; Don D Sin; Dave Singh; Robert Stockley; Jørgen Vestbo; Jadwiga A Wedzicha; Alvar Agustí Journal: Arch Bronconeumol Date: 2017-03-06 Impact factor: 4.872