Literature DB >> 34980884

Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities.

Jiaqi Liu1, Qing Xiao1, Jiani Xiao1, Chenxi Niu1, Yuanyuan Li1, Xiaojun Zhang1, Zhengwei Zhou1, Guang Shu1,2, Gang Yin3,4.   

Abstract

The Wnt/β-catenin pathway comprises a family of proteins that play critical roles in embryonic development and adult tissue homeostasis. The deregulation of Wnt/β-catenin signalling often leads to various serious diseases, including cancer and non-cancer diseases. Although many articles have reviewed Wnt/β-catenin from various aspects, a systematic review encompassing the origin, composition, function, and clinical trials of the Wnt/β-catenin signalling pathway in tumour and diseases is lacking. In this article, we comprehensively review the Wnt/β-catenin pathway from the above five aspects in combination with the latest research. Finally, we propose challenges and opportunities for the development of small-molecular compounds targeting the Wnt signalling pathway in disease treatment.
© 2021. The Author(s).

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Year:  2022        PMID： 34980884      PMCID： PMC8724284          DOI： 10.1038/s41392-021-00762-6

Source DB:  PubMed          Journal:  Signal Transduct Target Ther        ISSN： 2059-3635


  344 in total

1.  AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1.

Authors:  S Satoh; Y Daigo; Y Furukawa; T Kato; N Miwa; T Nishiwaki; T Kawasoe; H Ishiguro; M Fujita; T Tokino; Y Sasaki; S Imaoka; M Murata; T Shimano; Y Yamaoka; Y Nakamura
Journal:  Nat Genet       Date:  2000-03       Impact factor: 38.330

2.  Octamer 4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells.

Authors:  Stella Chai; Kai-Yu Ng; Man Tong; Eunice Y Lau; Terence K Lee; Kwok Wah Chan; Yun-Fei Yuan; Tan-To Cheung; Siu-Tim Cheung; Xiao-Qi Wang; Nathalie Wong; Chung-Mau Lo; Kwan Man; Xin-Yuan Guan; Stephanie Ma
Journal:  Hepatology       Date:  2016-10-27       Impact factor: 17.425

3.  Reduced Frizzled Receptor 4 Expression Prevents WNT/β-Catenin-driven Alveolar Lung Repair in Chronic Obstructive Pulmonary Disease.

Authors:  Wioletta Skronska-Wasek; Kathrin Mutze; Hoeke A Baarsma; Ken R Bracke; Hani N Alsafadi; Mareike Lehmann; Rita Costa; Mariano Stornaiuolo; Ettore Novellino; Guy G Brusselle; Darcy E Wagner; Ali Ö Yildirim; Melanie Königshoff
Journal:  Am J Respir Crit Care Med       Date:  2017-07-15       Impact factor: 21.405

Review 4.  Update on bone anabolics in osteoporosis treatment: rationale, current status, and perspectives.

Authors:  Roland Baron; Eric Hesse
Journal:  J Clin Endocrinol Metab       Date:  2012-01-11       Impact factor: 5.958

5.  An RNAi-based chemical genetic screen identifies three small-molecule inhibitors of the Wnt/wingless signaling pathway.

Authors:  Foster C Gonsalves; Keren Klein; Brittany B Carson; Shauna Katz; Laura A Ekas; Steve Evans; Robert Nagourney; Timothy Cardozo; Anthony M C Brown; Ramanuj DasGupta
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-10       Impact factor: 11.205

6.  Wnt/β-Catenin Signaling Plays a Protective Role in the Mdr2 Knockout Murine Model of Cholestatic Liver Disease.

Authors:  Tirthadipa Pradhan-Sundd; Karis Kosar; Harvinder Saggi; Rong Zhang; Ravi Vats; Pamela Cornuet; Sydney Green; Sucha Singh; Gang Zeng; Prithu Sundd; Kari Nejak-Bowen
Journal:  Hepatology       Date:  2019-12-31       Impact factor: 17.425

7.  LRP5 regulates human body fat distribution by modulating adipose progenitor biology in a dose- and depot-specific fashion.

Authors:  Nellie Y Loh; Matt J Neville; Kyriakoula Marinou; Sarah A Hardcastle; Barbara A Fielding; Emma L Duncan; Mark I McCarthy; Jonathan H Tobias; Celia L Gregson; Fredrik Karpe; Constantinos Christodoulides
Journal:  Cell Metab       Date:  2015-02-03       Impact factor: 27.287

8.  lncRNA MIR100HG-derived miR-100 and miR-125b mediate cetuximab resistance via Wnt/β-catenin signaling.

Authors:  Yuanyuan Lu; Xiaodi Zhao; Qi Liu; Cunxi Li; Ramona Graves-Deal; Zheng Cao; Bhuminder Singh; Jeffrey L Franklin; Jing Wang; Huaying Hu; Tianying Wei; Mingli Yang; Timothy J Yeatman; Ethan Lee; Kenyi Saito-Diaz; Scott Hinger; James G Patton; Christine H Chung; Stephan Emmrich; Jan-Henning Klusmann; Daiming Fan; Robert J Coffey
Journal:  Nat Med       Date:  2017-10-16       Impact factor: 53.440

9.  Multipoint targeting of TGF-β/Wnt transactivation circuit with microRNA 384-5p for cardiac fibrosis.

Authors:  Hyang-Hee Seo; Seahyoung Lee; Chang Youn Lee; Jiyun Lee; Sunhye Shin; Byeong-Wook Song; Il-Kwon Kim; Jung-Won Choi; Soyeon Lim; Sang Woo Kim; Ki-Chul Hwang
Journal:  Cell Death Differ       Date:  2018-09-11       Impact factor: 15.828

10.  Dose-Dependent and Subset-Specific Regulation of Midbrain Dopaminergic Neuron Differentiation by LEF1-Mediated WNT1/b-Catenin Signaling.

Authors:  Parivash Nouri; Sebastian Götz; Benedict Rauser; Martin Irmler; Changgeng Peng; Dietrich Trümbach; Christian Kempny; Carina G Lechermeier; Agnes Bryniok; Andrea Dlugos; Ellen Euchner; Johannes Beckers; Claude Brodski; Claudia Klümper; Wolfgang Wurst; Nilima Prakash
Journal:  Front Cell Dev Biol       Date:  2020-10-26
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  18 in total

1.  Carboxymethyl chitosan-alginate enhances bone repair effects of magnesium phosphate bone cement by activating the FAK-Wnt pathway.

Authors:  Ling Yu; Tian Gao; Wei Li; Jian Yang; Yinchu Liu; Yanan Zhao; Ping He; Xuefeng Li; Weichun Guo; Zhengfu Fan; Honglian Dai
Journal:  Bioact Mater       Date:  2022-07-01

2.  PRMT5 acts as a tumor suppressor by inhibiting Wnt/β-catenin signaling in murine gastric tumorigenesis.

Authors:  Yuling Tang; Lei Dong; Chong Zhang; Xiubin Li; Rongyu Li; Huisang Lin; Yini Qi; Mingchuan Tang; Yanli Peng; Chuan Liu; Jian Zhou; Ning Hou; Wenjia Liu; Guan Yang; Xiao Yang; Yan Teng
Journal:  Int J Biol Sci       Date:  2022-07-04       Impact factor: 10.750

Review 3.  TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer.

Authors:  Aina Martín-Medina; Noemi Cerón-Pisa; Esther Martinez-Font; Hanaa Shafiek; Antònia Obrador-Hevia; Jaume Sauleda; Amanda Iglesias
Journal:  Int J Mol Sci       Date:  2022-06-11       Impact factor: 6.208

4.  Role of Presenilin-1 in Aggressive Human Melanoma.

Authors:  Julia Sidor; Megan Gillette; Lindsay Ann Dezi; Gustavo Untiveros; Luigi Strizzi
Journal:  Int J Mol Sci       Date:  2022-04-28       Impact factor: 6.208

5.  The transformation of atrial fibroblasts into myofibroblasts is promoted by trimethylamine N-oxide via the Wnt3a/β-catenin signaling pathway.

Authors:  Wentao Yang; Qing Zhao; Minghui Yao; Xiangdong Li; Zhaoliang Shan; Yutang Wang
Journal:  J Thorac Dis       Date:  2022-05       Impact factor: 3.005

6.  Development and Validation of a Novel Histone Acetylation-Related Gene Signature for Predicting the Prognosis of Ovarian Cancer.

Authors:  Qinjin Dai; Ying Ye
Journal:  Front Cell Dev Biol       Date:  2022-02-18

7.  Pharmacological Activation of Potassium Channel Kv11.1 with NS1643 Attenuates Triple Negative Breast Cancer Cell Migration by Promoting the Dephosphorylation of Caveolin-1.

Authors:  Ying Jiang; Vitalyi Senyuk; Ke Ma; Hui Chen; Xiang Qin; Shun Li; Yiyao Liu; Saverio Gentile; Richard D Minshall
Journal:  Cells       Date:  2022-08-08       Impact factor: 7.666

Review 8.  Xanthogranuloma of the Sellar Region: A Comprehensive Review of Neuroimaging in a Rare Inflammatory Entity.

Authors:  Vera Lozovanu; Carmen Emanuela Georgescu; Lavinia Maria Florescu; Carmen Georgiu; Horatiu Silaghi; Andrian Fratea; Cristina Alina Silaghi
Journal:  J Pers Med       Date:  2022-06-08

9.  Genome-Wide Identification and Expression Profiling of the Wnt Gene Family in Three Rice Planthoppers: Sogatella furcifera, Laodelphax striatellus, and Nilaparvata lugens.

Authors:  Lei Peng; Yan Zhao
Journal:  J Insect Sci       Date:  2022-09-01       Impact factor: 2.066

10.  Downregulation of DNA methyltransferase-3a ameliorates the osteogenic differentiation ability of adipose-derived stem cells in diabetic osteoporosis via Wnt/β-catenin signaling pathway.

Authors:  Maorui Zhang; Yujin Gao; Qing Li; Huayue Cao; Jianghua Yang; Xiaoxiao Cai; Jingang Xiao
Journal:  Stem Cell Res Ther       Date:  2022-08-04       Impact factor: 8.079
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