| Literature DB >> 34979946 |
Mats L Junek1,2, Aaron Jones3, George Heckman4,5, Catherine Demers6,3, Lauren E Griffith6,7, Andrew P Costa6,3,4,7.
Abstract
BACKGROUND: Functional status is a patient-important, patient-centered measurement. The utility of functional status measures to inform post-discharge patient needs is unknown. We sought to examine the utility of routinely collected functional status measures gathered from older hospitalized patients to predict a panel of post-discharge outcomes.Entities:
Keywords: functional status; health services; routinely-collected data
Mesh:
Year: 2022 PMID: 34979946 PMCID: PMC8722185 DOI: 10.1186/s12877-021-02652-6
Source DB: PubMed Journal: BMC Geriatr ISSN: 1471-2318 Impact factor: 3.921
Demographics, comorbidities, and index hospitalization characteristics stratified by individual discharge outcome
| All | ED re-presentation | Re-admitted to hospital | LTCF ready | Death | None | |
|---|---|---|---|---|---|---|
| Patients (%) | 80 020 (100.0) | 38 928 (48.6) | 24 222 (30.3) | 5 037 (6.3) | 9 047 (11.3) | 35 831 (44.8) |
| Age** | 75.7 (75.7-75.8) | 76.4 (76.3-76.5) | 76.5 (76.4-76.6) | 81.5 (81.3-81.7) | 77.8 (77.7-78.0) | 74.8 (74.7-74.9) |
| Female | 51.2 | 50.7 | 48.6 | 60.3 | 45.8 | 51.8 |
| Income Quintile* | 3 (2-4) | 3 (2-4) | 3 (2-4) | 2 (1-4) | 3 (2-4) | 3 (2-4) |
| Lives Rurally | 21.5 | 23.7 | 20.8 | 22.2 | 23.8 | 18.9 |
| Family physician visits in last year** | 0.88 (0.87-0.88) | 0.90 (0.89-0.91) | 0.82 (0.80-0.83) | 0.62 (0.59-0.64) | 0.60 (0.58-0.62) | 0.91 (0.89-0.96) |
| Usual provider index** | 0.38 (0.38-0.38) | 0.35 (0.35-0.36) | 0.35 (0.35-0.35) | 0.40 (0.39-0.40) | 0.34 (0.34-0.35) | 0.40 (0.40-0.40) |
| days to outcome* | - | 36 (11-87) | 42 (14-92) | 51 (23-99) | 59 (27-106) | - |
| Comorbidities | ||||||
| Charlson comorbidity index** | 1.31 (1.30-1.33) | 1.51 (1.49-1.52) | 1.72 (1.69-1.74) | 1.45 (1.41-1.49) | 2.50 (2.45-2.54) | 1.03 (1.02-1.04) |
| Angina | 9.3 | 9.6 | 8.6 | 5.1 | 7.1 | 9.4 |
| Asthma | 0.8 | 0.7 | 0.7 | 0.5 | 0.4 | 0.9 |
| Coronary Artery Disease | 17.3 | 17.7 | 16.8 | 10.9 | 14.5 | 17.6 |
| Heart Failure | 13.0 | 15.6 | 17.7 | 15.7 | 21.6 | 10.1 |
| COPD | 10.9 | 12.5 | 13.2 | 10.7 | 15.5 | 9.4 |
| Diabetes | 22.8 | 24.4 | 25.9 | 23.1 | 25.3 | 21.2 |
| Epilepsy | 0.4 | 0.5 | 0.5 | 0.5 | 0.4 | 0.3 |
| Hypertension | 28.6 | 27.7 | 26.9 | 27.9 | 22.7 | 30.1 |
| Stroke | 2.4 | 2.1 | 1.9 | 3.8 | 1.7 | 2.6 |
| Delirium | 3.7 | 4.0 | 4.2 | 11.3 | 4.2 | 3.0 |
| Dementia | 1.1 | 1.1 | 1.2 | 5.3 | 1.4 | 0.8 |
| Injurious Fall | 6.1 | 5.0 | 4.4 | 11.8 | 3.6 | 7.0 |
| Index hospitalization characteristics | ||||||
| Length of stay* | 5 (3-7) | 5 (3-9) | 5 (3-10) | 8 (4-15) | 6 (4-11) | 4 (2-7) |
| Admitted to ICU | 13.4 | 13.0 | 12.6 | 8.3 | 10.1 | 14.2 |
| Discharge ADLH* | 0 (0-2) | 0 (0-2) | 0 (0-2) | 2 (0-4) | 1 (0-3) | 0 (0-1) |
ICU = intensive care unit; ADLH = activities of daily living hierarchy; COPD = chronic obstructive pulmonary disease. *median and interquartile range;
**mean and 95% Confidence interval
Fig. 1Proportion of patients in the cohort with each outcome by age and discharge ADLH (dADLH). 0 = independent; 1 = requires supervision; 2 = requires limited assistance; 3 = requires extensive assistance; 4 = requires maximal assistance; 5 = dependent. Patients who experienced more than one outcome were included in each
Predictive Utility of Discharge Functional Status (limited or no ADL support vs. extensive or more ADL) for each outcome using unadjusted analysis
| Outcome | Sensitivity (95% CI) | Specificity | Odds Ratio | Positive LR | Negative LR |
|---|---|---|---|---|---|
13.9% (13.5-14.2) | 88.5% (87.6-89.4) | 1.24 (1.19 – 1.30) | 1.21 (1.17 – 1.25) | 0.97 (0.97 – 0.98) | |
16.0% (15.6-16.5) | 88.8% (88.1-89.6) | 1.52 (1.46 – 1.59) | 1.44 (1.39 – 1.49) | 0.95 (0.94 – 0.95) | |
37.9% (36.5-39.2) | 89.1% (88.4-89.7) | 4.96 (4.67 – 5.28) | 3.46 (3.32 – 3.61) | 0.70 (0.68 – 0.71) | |
26.9% (26.0-27.8) | 89.2% (88.5-89.9) | 3.04 (2.89 – 3.20) | 2.49 (2.39 – 2.59) | 0.82 (0.81 – 0.83) |
LR = likelihood ratio
Adjusted Odds Ratios by outcome
| ED Re-presentation | Hospital | LTCF Readiness | Death | |||||
|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | OR | 95% CI | OR | 95% CI | OR | 95% CI | |
| Age 70-74* | 1.08 | (1.03-1.13) | 1.08 | (1.02-1.13) | 1.36 | (1.15-1.61) | 1.14 | (1.05-1.25) |
| 75-79* | 1.19 | (1.14-1.24) | 1.18 | (1.12-1.24) | 2.52 | (2.16-2.93) | 1.38 | (1.26-1.50) |
| 80-84* | 1.32 | (1.26-1.38) | 1.27 | (1.21-1.34) | 3.61 | (3.12-4.17) | 1.59 | (1.47-1.73) |
| 85-89* | 1.48 | (1.41-1.56) | 1.39 | (1.31-1.47) | 5.06 | (4.37-5.85) | 1.81 | (1.65-1.97) |
| ≥90* | 1.67 | (1.57-1.78) | 1.51 | (1.41-1.62) | 7.22 | (6.21-8.39) | 2.47 | (2.24-2.73) |
| Sex (F v M) | 0.97 | (0.94-1.00) | 0.86 | (0.84-0.89) | 1.16 | (1.09-1.23) | 0.76 | (0.73-0.80) |
| Income Quintile 2 ** | 0.90 | (0.86-0.94) | 0.96 | (0.91-1.00) | 0.82 | (0.75-0.89) | 1.03 | (0.96-1.11) |
| 3 ** | 0.87 | (0.83-0.9) | 0.97 | (0.93-1.02) | 0.78 | (0.71-0.85) | 1.04 | (0.97-1.12) |
| 4 ** | 0.84 | (0.8-0.87) | 0.94 | (0.89-0.98) | 0.69 | (0.62-0.76) | 1.01 | (0.94-1.09) |
| 5 ** | 0.83 | (0.79-0.86) | 0.94 | (0.89-0.98) | 0.71 | (0.65-0.78) | 0.97 | (0.9-1.04) |
| Lives Rurally | 1.38 | (1.33-1.42) | 0.97 | (0.93-1.01) | 1.13 | (1.05-1.22) | 1.19 | (1.12-1.26) |
| Usual Provider index | 0.92 | (0.88-0.96) | 0.91 | (0.87-0.96) | 0.71 | (0.63-0.79) | 0.77 | (0.71-0.84) |
| FP visits | 1.08 | (1.06-1.10) | 0.95 | (0.94-0.97) | 0.86 | (0.83-0.90) | 0.78 | (0.76-0.80) |
| ICU admit | 0.92 | (0.88-0.96) | 0.91 | (0.87-0.96) | 0.71 | (0.63-0.79) | 0.77 | (0.71-0.84) |
| Length of Stay | 1.00 | (1.00-1.00) | 1.01 | (1.00-1.01) | 1.02 | (1.01-1.02) | 1.00 | (1.00-1.00) |
| Discharge ADLH | ||||||||
| Independent | Referent | Referent | Referent | Referent | ||||
| Supervision | 1.16 | (1.10-1.22) | 1.22 | (1.16-1.30) | 2.52 | (2.27-2.80) | 1.57 | (1.44-1.71) |
| Limited Assist | 1.24 | (1.19-1.29) | 1.33 | (1.27-1.39) | 2.86 | (2.63-3.12) | 1.87 | (1.75-2.00) |
| Extensive Assist | 1.42 | (1.30-1.54) | 1.44 | (1.32-1.57) | 4.75 | (4.21-5.35) | 2.46 | (2.20-2.75) |
| Max Assist | 1.27 | (1.18-1.36) | 1.52 | (1.41-1.64) | 4.90 | (4.40-5.47) | 2.95 | (2.67-3.24) |
| Dependent | 1.11 | (1.04-1.19) | 1.44 | (1.34-1.54) | 4.11 | (3.70-4.57) | 3.99 | (3.67-4.35) |
| Comorbidities | ||||||||
| CCI | 1.15 | (1.14-1.17) | 1.23 | (1.22-1.25) | 1.02 | (0.99-1.04) | 1.59 | (1.57-1.61) |
| Angina | 1.08 | (1.01-1.16) | 0.91 | (0.84-0.98) | 0.85 | (0.71-1.02) | 0.88 | (0.77-0.99) |
| Coronary Artery Disease | 0.95 | (0.90-1.00) | 0.91 | (0.85-0.96) | 0.82 | (0.72-0.93) | 0.80 | (0.73-0.88) |
| Heart Failure | 1.18 | (1.12-1.23) | 1.25 | (1.20-1.31) | 1.05 | (0.96-1.15) | 1.26 | (1.18-1.34) |
| COPD | 1.15 | (1.10-1.20) | 1.09 | (1.04-1.14) | 1.02 | (0.93-1.13) | 1.07 | (1.00-1.14) |
| Delirium | 1.07 | (0.99-1.16) | 0.96 | (0.89-1.05) | 1.88 | (1.69-2.10) | 0.74 | (0.65-0.83) |
| Dementia | 0.87 | (0.76-1.00) | 0.87 | (0.75-1.00) | 3.04 | (2.59-3.57) | 0.67 | (0.54-0.82) |
| Diabetes | 0.95 | (0.91-0.99) | 0.90 | (0.87-0.94) | 1.09 | (1.00-1.18) | 0.56 | (0.53-0.60) |
| Injurious Fall | 0.71 | (0.67-0.76) | 0.63 | (0.59-0.68) | 1.21 | (1.10-1.34) | 0.50 | (0.44-0.56) |
| Hypertension | 0.89 | (0.86-0.92) | 0.85 | (0.82-0.88) | 0.88 | (0.82-0.95) | 0.68 | (0.64-0.72) |
| Seizure | 0.73 | (0.66-0.80) | 0.62 | (0.55-0.69) | 1.41 | (1.19-1.67) | 0.43 | (0.36-0.52) |
| Stroke | 1.63 | (1.30-2.05) | 1.31 | (1.03-1.66) | 1.23 | (0.80-1.88) | 1.02 | (0.70-1.48) |
*compared to age 65-69; **compared to income quintile 1; FP = family physician; CCI = Charlton Comorbidity Index; COPD = Chronic Obstructive Pulmonary Disease