An environment-friendly methodology for the construction of diversified bicycloacenaphtho[1,2-d]imidazole-8-thione scaffolds using spinel NiFe2O4 nanoparticles as a sustainable catalyst.

Herein, we successfully developed an easy access to bicycloacenaphtho[1,2-d]imidazole-8-thione by one-pot three-component MCRs of acenaphthoquinone, aryl or alkyl isothiocyanates and amines using environmentally benevolent and recyclable spinel NiFe2O4 nanocatalyst in aqueous ethanol. A broad number of products have been synthesized with both EDGs and EWGs present in the ring which increases the diversity of the protocol. The NiFe2O4 nanopowder has been synthesized and thoroughly characterized by powdered XRD, HRTEM, EDX, BET and ICP-AES analysis. The protocol to this bicyclic-heterocycle is noteworthy due to good to excellent yields, practical simplicity and high regioselectivity without any troublesome or hazardous by-products and its easy recovery and reusability of the catalyst. Spinel NiFe2O4 NPs-catalysed synthesis of various bicycloacenaphtho[1,2-d]imidazole-8-thione scaffolds under mild and sustainable conditions.