Literature DB >> 3497621

Interaction of carbon tetrachloride and progesterone metabolism in liver microsomes from triacetyloleandomycin-treated rats.

C Larroque, R Lange.   

Abstract

The production of progesterone metabolites by rat liver microsomes from TAO-treated rats was investigated. More than ten metabolites could be identified, including various dihydroxy-progesterones. CCl4 co-incubation modifies the P-450-dependent progesterone metabolite profile in a remarkable fashion without production of CCl4 progesterone adducts.

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Year:  1987        PMID： 3497621     DOI： 10.1007/BF00296963

Source DB:  PubMed          Journal:  Arch Toxicol        ISSN： 0340-5761            Impact factor:   5.153


  7 in total

1.  THE CARBON MONOXIDE-BINDING PIGMENT OF LIVER MICROSOMES. II. SOLUBILIZATION, PURIFICATION, AND PROPERTIES.

Authors:  T OMURA; R SATO
Journal:  J Biol Chem       Date:  1964-07       Impact factor: 5.157

2.  Partial purification of cytochromes P-450 and P-448 from rat liver microsomes.

Authors:  A Y Lu; W Levin
Journal:  Biochem Biophys Res Commun       Date:  1972-02-16       Impact factor: 3.575

3.  Metabolism of carbon tetrachloride to electrophilic chlorine by liver microsomes: exclusion of cytochrome P-450 catalyzed chloroperoxidase reaction.

Authors:  B A Mico; L R Pohl
Journal:  Biochem Biophys Res Commun       Date:  1982-07-16       Impact factor: 3.575

4.  Self-induction by triacetyloleandomycin of its own transformation into a metabolite forming a stable 456 nm-absorbing complex with cytochrome P-450.

Authors:  D Pessayre; V Descatoire; M Konstantinova-Mitcheva; J C Wandscheer; B Cobert; R Level; P J Benhamou; M Jaouen; D Mansuy
Journal:  Biochem Pharmacol       Date:  1981-03-15       Impact factor: 5.858

5.  O2-independent damage of cytochrome P450 by CCl4-metabolites in hepatic microsomes.

Authors:  H de Groot; W Haas
Journal:  FEBS Lett       Date:  1980-06-30       Impact factor: 4.124

6.  Hydroxylation of prostaglandins by inducible isozymes of rabbit liver microsomal cytochrome P-450. Participation of cytochrome b5.

Authors:  K P Vatsis; A D Theoharides; D Kupfer; M J Coon
Journal:  J Biol Chem       Date:  1982-10-10       Impact factor: 5.157

7.  Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes.

Authors:  A W Wood; D E Ryan; P E Thomas; W Levin
Journal:  J Biol Chem       Date:  1983-07-25       Impact factor: 5.157
  7 in total

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