Literature DB >> 34975504

Mechanism of Hedyotis Diffusa in the Treatment of Cervical Cancer.

Kai Qian1,2, Dan Fu2, Baorui Jiang2, Yue Wang2, Fei Tian2, Li Song2, Lei Li1,2.   

Abstract

Cervical cancer is one of the most common malignant tumors among women in the world. In clinical practice, Hedyotis diffusa has pharmacological effects in treating cervical cancer, but its components are relatively complex, and the mechanism of Hedyotis diffusa in treating cervical cancer is still unclear. In this work, the potential active components and mechanism of Hedyotis diffusa in the treatment of cervical cancer were explored by means of network pharmacology. By constructing its active ingredient-target network, and enriching and analyzing the targets, we found the key targets and their effective components (beta-Sitosterol and Quercetin) that play a therapeutic role. Finally, we evaluated the prognostic value of the core target genes through survival analysis. Our work initially explored the therapeutic mechanism of cervical cancer, which lays a theoretical foundation for further exploring its pharmacological action and its clinical application.
Copyright © 2021 Qian, Fu, Jiang, Wang, Tian, Song and Li.

Entities:  

Keywords:  cervical cancer; component; hedyotis diffusa; mechanism; network pharmacology

Year:  2021        PMID: 34975504      PMCID: PMC8715005          DOI: 10.3389/fphar.2021.808144

Source DB:  PubMed          Journal:  Front Pharmacol        ISSN: 1663-9812            Impact factor:   5.810


  30 in total

1.  Extract of Hedyotis diffusa Willd influences murine leukemia WEHI-3 cells in vivo as well as promoting T- and B-cell proliferation in leukemic mice.

Authors:  Chin-Chung Lin; Chao-Lin Kuo; Mau-Hva Lee; Shu-Chun Hsu; An-Cheng Huang; Nou-Ying Tang; Jing-Pin Lin; Jai-Sing Yang; Chi-Cheng Lu; Jo-Hua Chiang; Fu-Shin Chueh; Jing-Gung Chung
Journal:  In Vivo       Date:  2011 Jul-Aug       Impact factor: 2.155

2.  The anti-apoptotic role of interleukin-6 in human cervical cancer is mediated by up-regulation of Mcl-1 through a PI 3-K/Akt pathway.

Authors:  L H Wei; M L Kuo; C A Chen; C H Chou; W F Cheng; M C Chang; J L Su; C Y Hsieh
Journal:  Oncogene       Date:  2001-09-13       Impact factor: 9.867

Review 3.  Cervical cancer.

Authors:  Paul A Cohen; Anjua Jhingran; Ana Oaknin; Lynette Denny
Journal:  Lancet       Date:  2019-01-12       Impact factor: 79.321

Review 4.  Role of Immunotherapy in the Management of Locally Advanced and Recurrent/Metastatic Cervical Cancer.

Authors:  Brandon A Dyer; Dmitriy Zamarin; Ramez N Eskandar; Jyoti M Mayadev
Journal:  J Natl Compr Canc Netw       Date:  2019-01       Impact factor: 11.908

5.  Molecular regulation of cervical cancer growth and invasion by VEGFa.

Authors:  Baohuan Chen; Chunxiao Zhang; Pingping Dong; Yuanying Guo; Nan Mu
Journal:  Tumour Biol       Date:  2014-08-19

6.  Circulating IL-1beta levels, polymorphisms of IL-1B, and risk of cervical cancer in Chinese women.

Authors:  Nianfeng Qian; Xiaojun Chen; Suping Han; Fulin Qiang; Guangfu Jin; Xiaoyi Zhou; Jing Dong; Xinru Wang; Hongbing Shen; Zhibin Hu
Journal:  J Cancer Res Clin Oncol       Date:  2009-11-11       Impact factor: 4.553

7.  Application of novel loop-mediated isothermal amplification (LAMP) for rapid authentication of the herbal tea ingredient Hedyotis diffusa Willd.

Authors:  Ming Li; Yuk-Lau Wong; Li-Li Jiang; Ka-Lok Wong; Yuen-Ting Wong; Clara Bik-San Lau; Pang-Chui Shaw
Journal:  Food Chem       Date:  2013-05-24       Impact factor: 7.514

8.  Quercetin attenuated oxidative DNA damage through NRF2 signaling pathway in rats with DMH induced colon carcinogenesis.

Authors:  Saber Ghazizadeh Darband; Shirin Sadighparvar; Bahman Yousefi; Mojtaba Kaviani; Firouz Ghaderi-Pakdel; Ainaz Mihanfar; Yaghoub Rahimi; Kazhal Mobaraki; Maryam Majidinia
Journal:  Life Sci       Date:  2020-03-24       Impact factor: 5.037

9.  MiR-125 inhibited cervical cancer progression by regulating VEGF and PI3K/AKT signaling pathway.

Authors:  Ke Fu; Ling Zhang; Rui Liu; Qi Shi; Xue Li; Min Wang
Journal:  World J Surg Oncol       Date:  2020-05-30       Impact factor: 2.754

Review 10.  The Hedyotis diffusa Willd. (Rubiaceae): A Review on Phytochemistry, Pharmacology, Quality Control and Pharmacokinetics.

Authors:  Rui Chen; Jingyu He; Xueli Tong; Lan Tang; Menghua Liu
Journal:  Molecules       Date:  2016-05-30       Impact factor: 4.411

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  1 in total

1.  Network Pharmacology Was Used to Predict the Active Components and Prospective Targets of Paeoniae Radix Alba for Treatment in Endometriosis.

Authors:  Yuting Sun; Junhong Cai; Shun Ding; Shan Bao
Journal:  Reprod Sci       Date:  2022-10-18       Impact factor: 2.924

  1 in total

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