Literature DB >> 34975154

Biology and evolution of bacterial toxin-antitoxin systems.

Dukas Jurėnas1, Nathan Fraikin2, Frédéric Goormaghtigh3, Laurence Van Melderen4.   

Abstract

Toxin-antitoxin systems are widespread in bacterial genomes. They are usually composed of two elements: a toxin that inhibits an essential cellular process and an antitoxin that counteracts its cognate toxin. In the past decade, a number of new toxin-antitoxin systems have been described, bringing new growth inhibition mechanisms to light as well as novel modes of antitoxicity. However, recent advances in the field profoundly questioned the role of these systems in bacterial physiology, stress response and antimicrobial persistence. This shifted the paradigm of the functions of toxin-antitoxin systems to roles related to interactions between hosts and their mobile genetic elements, such as viral defence or plasmid stability. In this Review, we summarize the recent progress in understanding the biology and evolution of these small genetic elements, and discuss how genomic conflicts could shape the diversification of toxin-antitoxin systems.
© 2022. Springer Nature Limited.

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Year:  2022        PMID： 34975154     DOI： 10.1038/s41579-021-00661-1

Source DB:  PubMed          Journal:  Nat Rev Microbiol        ISSN： 1740-1526            Impact factor:   60.633


  227 in total

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Journal:  J Bacteriol       Date:  1986-04       Impact factor: 3.490

2.  Translational control and differential RNA decay are key elements regulating postsegregational expression of the killer protein encoded by the parB locus of plasmid R1.

Authors:  K Gerdes; K Helin; O W Christensen; A Løbner-Olesen
Journal:  J Mol Biol       Date:  1988-09-05       Impact factor: 5.469

3.  Effects of the ccd function of the F plasmid on bacterial growth.

Authors:  A Jaffé; T Ogura; S Hiraga
Journal:  J Bacteriol       Date:  1985-09       Impact factor: 3.490

Review 4.  Programmed cell death in bacterial populations.

Authors:  M B Yarmolinsky
Journal:  Science       Date:  1995-02-10       Impact factor: 47.728

5.  Mini-F plasmid genes that couple host cell division to plasmid proliferation.

Authors:  T Ogura; S Hiraga
Journal:  Proc Natl Acad Sci U S A       Date:  1983-08       Impact factor: 11.205

6.  The F plasmid ccd autorepressor is a complex of CcdA and CcdB proteins.

Authors:  J E Tam; B C Kline
Journal:  Mol Gen Genet       Date:  1989-10

7.  Unique type of plasmid maintenance function: postsegregational killing of plasmid-free cells.

Authors:  K Gerdes; P B Rasmussen; S Molin
Journal:  Proc Natl Acad Sci U S A       Date:  1986-05       Impact factor: 11.205

8.  Lon-dependent proteolysis of CcdA is the key control for activation of CcdB in plasmid-free segregant bacteria.

Authors:  L Van Melderen; P Bernard; M Couturier
Journal:  Mol Microbiol       Date:  1994-03       Impact factor: 3.501

9.  Mechanism of postsegregational killing by the hok gene product of the parB system of plasmid R1 and its homology with the relF gene product of the E. coli relB operon.

Authors:  K Gerdes; F W Bech; S T Jørgensen; A Løbner-Olesen; P B Rasmussen; T Atlung; L Boe; O Karlstrom; S Molin; K von Meyenburg
Journal:  EMBO J       Date:  1986-08       Impact factor: 11.598

10.  Ham22, a mini-F mutation which is lethal to host cell and promotes recA-dependent induction of lambdoid prophage.

Authors:  H Karoui; F Bex; P Drèze; M Couturier
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
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  15 in total

1.  GNAT toxins evolve toward narrow tRNA target specificities.

Authors:  Dmitry Bikmetov; Alexander M J Hall; Alexei Livenskyi; Bridget Gollan; Stepan Ovchinnikov; Konstantin Gilep; Jenny Y Kim; Gerald Larrouy-Maumus; Viktor Zgoda; Sergei Borukhov; Konstantin Severinov; Sophie Helaine; Svetlana Dubiley
Journal:  Nucleic Acids Res       Date:  2022-06-10       Impact factor: 19.160

2.  Antitoxin CrlA of CrlTA Toxin-Antitoxin System in a Clinical Isolate Pseudomonas aeruginosa Inhibits Lytic Phage Infection.

Authors:  Muyang Ni; Jianzhong Lin; Jiayu Gu; Shituan Lin; Mei He; Yunxue Guo
Journal:  Front Microbiol       Date:  2022-05-10       Impact factor: 6.064

3.  Substrate recognition and cryo-EM structure of the ribosome-bound TAC toxin of Mycobacterium tuberculosis.

Authors:  Moise Mansour; Emmanuel Giudice; Xibing Xu; Hatice Akarsu; Patricia Bordes; Valérie Guillet; Donna-Joe Bigot; Nawel Slama; Gaetano D'urso; Sophie Chat; Peter Redder; Laurent Falquet; Lionel Mourey; Reynald Gillet; Pierre Genevaux
Journal:  Nat Commun       Date:  2022-05-12       Impact factor: 17.694

4.  A Shift in Perspective: A Role for the Type I Toxin TisB as Persistence-Stabilizing Factor.

Authors:  Daniel Edelmann; Bork A Berghoff
Journal:  Front Microbiol       Date:  2022-03-17       Impact factor: 5.640

Review 5.  Recruitment of Mobile Genetic Elements for Diverse Cellular Functions in Prokaryotes.

Authors:  Sean Benler; Eugene V Koonin
Journal:  Front Mol Biosci       Date:  2022-03-24

6.  The HipAB Toxin-Antitoxin System Stabilizes a Composite Genomic Island in Shewanella putrefaciens CN-32.

Authors:  Yi Zhao; Weiquan Wang; Jianyun Yao; Xiaoxue Wang; Dong Liu; Pengxia Wang
Journal:  Front Microbiol       Date:  2022-03-21       Impact factor: 5.640

7.  Comprehensive deciphering prophages in genus Acetobacter on the ecology, genomic features, toxin-antitoxin system, and linkage with CRISPR-Cas system.

Authors:  Chenggong Qian; Jiawen Ma; Jiale Liang; Lei Zhang; Xinle Liang
Journal:  Front Microbiol       Date:  2022-08-02       Impact factor: 6.064

8.  Molecular mechanism of toxin neutralization in the HipBST toxin-antitoxin system of Legionella pneumophila.

Authors:  Xiangkai Zhen; Yongyu Wu; Jinli Ge; Jiaqi Fu; Le Ye; Niannian Lin; Zhijie Huang; Zihe Liu; Zhao-Qing Luo; Jiazhang Qiu; Songying Ouyang
Journal:  Nat Commun       Date:  2022-07-26       Impact factor: 17.694

9.  Structural and mutational analysis of MazE6-operator DNA complex provide insights into autoregulation of toxin-antitoxin systems.

Authors:  Khushboo Kumari; Siddhartha P Sarma
Journal:  Commun Biol       Date:  2022-09-15

Review 10.  Are all antibiotic persisters created equal?

Authors:  Michael W Shultis; Claire V Mulholland; Michael Berney
Journal:  Front Cell Infect Microbiol       Date:  2022-08-17       Impact factor: 6.073
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