Literature DB >> 3497349

Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells.

A Sette, S Buus, S Colon, J A Smith, C Miles, H M Grey.   

Abstract

A detailed analysis of the residues within an immunogenic peptide that endow it with the capacity to interact with Ia and to be recognized by T cells is presented. Ia interacts with only a few of the peptide residues and overall exhibits a very broad specificity. Some residues appear to interact both with Ia and with T cells, leading to a model in which a peptide antigen is 'sandwiched' between Ia and the T-cell receptor.

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Year:  1987        PMID： 3497349     DOI： 10.1038/328395a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  96 in total

1.  The principle of delivery of T cell epitopes to antigen-presenting cells applied to peptides from influenza virus, ovalbumin, and hen egg lysozyme: implications for peptide vaccination.

Authors:  I B Rasmussen; E Lunde; T E Michaelsen; B Bogen; I Sandlie
Journal:  Proc Natl Acad Sci U S A       Date:  2001-08-21       Impact factor: 11.205

2.  Specificity of peptide selection by antigen-presenting cells homozygous or heterozygous for expression of class II MHC molecules: The lack of competition.

Authors:  Anish Suri; James J Walters; Osami Kanagawa; Michael L Gross; Emil R Unanue
Journal:  Proc Natl Acad Sci U S A       Date:  2003-04-07       Impact factor: 11.205

3.  Distinct recognition by two subsets of T cells of an MHC class II-peptide complex.

Authors:  Zheng Pu; Javier A Carrero; Emil R Unanue
Journal:  Proc Natl Acad Sci U S A       Date:  2002-06-25       Impact factor: 11.205

4.  Expression of alternatively spliced HLA class II transcripts in lymphoid and nonlymphoid tissues.

Authors:  C Seidl; J S Lee
Journal:  Immunogenetics       Date:  1992       Impact factor: 2.846

5.  Selection for class II Mhc heterozygosity by parasites in subterranean mole rats.

Authors:  E Nevo; A Beiles
Journal:  Experientia       Date:  1992-05-15

6.  Reassociation with beta 2-microglobulin is necessary for Kb class I major histocompatibility complex binding of exogenous peptides.

Authors:  K L Rock; L E Rothstein; S R Gamble; B Benacerraf
Journal:  Proc Natl Acad Sci U S A       Date:  1990-10       Impact factor: 11.205

Review 7.  Interactions between immunogenic peptides and HLA-DR molecules.

Authors:  J B Rothbard; R Busch
Journal:  Immunol Res       Date:  1990       Impact factor: 2.829

8.  Rapid typing of HLA-DQB1 DNA polymorphism using nonradioactive oligonucleotide probes and amplified DNA.

Authors:  T L Bugawan; H A Erlich
Journal:  Immunogenetics       Date:  1991       Impact factor: 2.846

9.  A specific HLA-DP beta allele is associated with pauciarticular juvenile rheumatoid arthritis but not adult rheumatoid arthritis.

Authors:  A B Begovich; T L Bugawan; B S Nepom; W Klitz; G T Nepom; H A Erlich
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

10.  Inhibition of T-cell reactivity to myasthenogenic epitopes of the human acetylcholine receptor by synthetic analogs.

Authors:  Y Katz-Levy; S L Kirshner; M Sela; E Mozes
Journal:  Proc Natl Acad Sci U S A       Date:  1993-08-01       Impact factor: 11.205
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