Kiyong Na1, Ha Young Woo2, Sung-Im DO3, So-Woon Kim4. 1. Department of Pathology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea. 2. Department of Pathology, National Cancer Center, Goyang, Republic of Korea. 3. Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea sowoonkim86@gmail.com sungim.do@samsung.com. 4. Department of Pathology, Kyung Hee University Hospital, Kyung Hee University College of Medicine, Seoul, Republic of Korea; sowoonkim86@gmail.com sungim.do@samsung.com.
Abstract
BACKGROUND/AIM: It can be difficult to establish the origin of a tumor in metastatic breast cancer (MBC), especially with triple-negative breast cancer (TNBC) or high-grade features. We evaluated the diagnostic utility of GATA3, SOX10, and PAX8 panels in MBC by comparing their expression in each molecular subtype of MBC. PATIENTS AND METHODS: We evaluated 84 MBC and 37 primary TNBC cases using GATA3, SOX10, and PAX8 staining in whole tissue sections. RESULTS: GATA3 was least sensitive in the detection of metastatic TNBC (metastatic non-TNBC, 0.95; metastatic TNBC, 0.37). SOX10 had the lowest overall sensitivity (0.12) but was elevated in metastatic TNBC, even higher than GATA3 (0.59 vs. 0.37). The combination of GATA3, SOX10, and PAX8 expression showed the highest detection rate (MBC, 0.94; metastatic non-TNBC, 0.95; metastatic TNBC, 0.93). CONCLUSION: We recommend combining GATA3, SOX10, PAX8 expression profiling to confirm breast as the site of origin in metastatic MBC.
BACKGROUND/AIM: It can be difficult to establish the origin of a tumor in metastatic breast cancer (MBC), especially with triple-negative breast cancer (TNBC) or high-grade features. We evaluated the diagnostic utility of GATA3, SOX10, and PAX8 panels in MBC by comparing their expression in each molecular subtype of MBC. PATIENTS AND METHODS: We evaluated 84 MBC and 37 primary TNBC cases using GATA3, SOX10, and PAX8 staining in whole tissue sections. RESULTS: GATA3 was least sensitive in the detection of metastatic TNBC (metastatic non-TNBC, 0.95; metastatic TNBC, 0.37). SOX10 had the lowest overall sensitivity (0.12) but was elevated in metastatic TNBC, even higher than GATA3 (0.59 vs. 0.37). The combination of GATA3, SOX10, and PAX8 expression showed the highest detection rate (MBC, 0.94; metastatic non-TNBC, 0.95; metastatic TNBC, 0.93). CONCLUSION: We recommend combining GATA3, SOX10, PAX8 expression profiling to confirm breast as the site of origin in metastatic MBC.
Authors: Markku Miettinen; Peter A McCue; Maarit Sarlomo-Rikala; Wojciech Biernat; Piotr Czapiewski; Janusz Kopczynski; Lester D Thompson; Jerzy Lasota; Zengfeng Wang; John F Fetsch Journal: Am J Surg Pathol Date: 2015-06 Impact factor: 6.394
Authors: Akosua B Domfeh; AnnaMarie L Carley; Joan M Striebel; Rouzan G Karabakhtsian; Anca V Florea; Kim McManus; Sushil Beriwal; Rohit Bhargava Journal: Mod Pathol Date: 2008-05-09 Impact factor: 7.842
Authors: Ashley Cimino-Mathews; Andrea P Subhawong; Hillary Elwood; Hind Nassar Warzecha; Rajni Sharma; Ben Ho Park; Janis M Taube; Peter B Illei; Pedram Argani Journal: Hum Pathol Date: 2012-12-20 Impact factor: 3.466