Takeo Nakajima1, Tatsuya Nagano2, Teruaki Nishiuma3, Kyosuke Nakata4, Yoshihiro Nishimura4. 1. Nakajima Medical Clinic, Kobe, Japan. 2. Division of Respiratory Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine, Kobe, Japan; tnagano@med.kobe-u.ac.jp. 3. Department of Respiratory Medicine, Kakogawa Central City Hospital, Kakogawa, Japan. 4. Division of Respiratory Medicine, Department of Internal Medicine Kobe University Graduate School of Medicine, Kobe, Japan.
Abstract
BACKGROUND/AIM: Measuring the fraction of exhaled nitric oxide (FeNO) is useful in the diagnosis of asthma and cough variant asthma. The aim of this study was to clarify the significance of measuring the FeNO in the differential diagnosis of acute cough. PATIENTS AND METHODS: We analyzed 80 patients who visited the clinic with the chief complaint of acute cough having experienced an asthma-like episode from January 2014 to July 2015. RESULTS: Infectious cough alone was present in 21% of patients, while 30% had asthmatic cough alone and 49% had a combination of infectious and asthmatic cough. The values of FeNO in those with asthmatic cough (30.4±24.7 ppb) and asthmatic/infectious cough (33.2±17.4 ppb) were significantly higher than those with just infectious cough (13.7±3.2 ppb) (p=0.0089 and p<0.0001, respectively). CONCLUSION: FeNO measurement is useful for distinguishing asthmatic diseases, even in the differential diagnosis of acute cough.
BACKGROUND/AIM: Measuring the fraction of exhaled nitric oxide (FeNO) is useful in the diagnosis of asthma and cough variant asthma. The aim of this study was to clarify the significance of measuring the FeNO in the differential diagnosis of acute cough. PATIENTS AND METHODS: We analyzed 80 patients who visited the clinic with the chief complaint of acute cough having experienced an asthma-like episode from January 2014 to July 2015. RESULTS: Infectious cough alone was present in 21% of patients, while 30% had asthmatic cough alone and 49% had a combination of infectious and asthmatic cough. The values of FeNO in those with asthmatic cough (30.4±24.7 ppb) and asthmatic/infectious cough (33.2±17.4 ppb) were significantly higher than those with just infectious cough (13.7±3.2 ppb) (p=0.0089 and p<0.0001, respectively). CONCLUSION: FeNO measurement is useful for distinguishing asthmatic diseases, even in the differential diagnosis of acute cough.
Authors: Stefan Karrasch; Klaus Linde; Gerta Rücker; Harriet Sommer; Marlies Karsch-Völk; Jos Kleijnen; Rudolf A Jörres; Antonius Schneider Journal: Thorax Date: 2016-07-07 Impact factor: 9.139
Authors: Anne G Mosser; Rose Vrtis; Lacinda Burchell; Wai-Ming Lee; Claire R Dick; Elizabeth Weisshaar; Diane Bock; Cheri A Swenson; Richard D Cornwell; Keith C Meyer; Nizar N Jarjour; William W Busse; James E Gern Journal: Am J Respir Crit Care Med Date: 2004-12-10 Impact factor: 21.405
Authors: Peter A B Wark; Sebastian L Johnston; Fabio Bucchieri; Robert Powell; Sarah Puddicombe; Vasile Laza-Stanca; Stephen T Holgate; Donna E Davies Journal: J Exp Med Date: 2005-03-21 Impact factor: 14.307