Bo Hae Kim1,2, Hee-Bok Kim1, Joo Hyun Park1,2, Chang Gun Cho1,2, Seok-Won Park3,2, Yun-Sung Lim4,2. 1. Department of Otorhinolaryngology-Head and Neck Surgery, Dongguk University Ilsan Hospital, College of Medicine, Goyang, Republic of Korea. 2. Sensory Organ Research Institute, College of Medicine, Dongguk University, Gyengju, Republic of Korea. 3. Department of Otorhinolaryngology-Head and Neck Surgery, Dongguk University Ilsan Hospital, College of Medicine, Goyang, Republic of Korea; sw43857@dumc.or.kr. 4. Department of Otorhinolaryngology-Head and Neck Surgery, Dongguk University Ilsan Hospital, College of Medicine, Goyang, Republic of Korea; yslim0503@gmail.com.
Abstract
BACKGROUND/AIM: This study aimed to investigate the process of homeostatic restoration in the tracheal mucosa (TM) after thyroid surgery. MATERIALS AND METHODS: Fifty-four rats were divided into normal controls (NC) and three experimental groups: (i) flap elevation (FE), (ii) thyroid exposure (TE), and (iii) thyroid isthmusectomy (TI). Expression of mRNA and proteins of key factors regulating homeostasis were evaluated in the TM obtained 3, 7, and 21 days after thyroid surgery. RESULTS: Increased mRNA expression of transforming growth factor-β1 (TGF-β1), hypoxia-inducible factor-1α (HIF-1α), and matrix metalloproteinase-9 (MMP-9) were observed 21 days after thyroid surgery in all experimental groups compared to that of NC group. CONCLUSION: Thyroid surgery leads to an actual increase of TGF-β1, HIF-1α, and MMP-9 expression in the TM. This increased expression of key regulators of homeostatic restoration in the TM lasts for a considerable period of time after surgery, especially if the extent of surgery increased.
BACKGROUND/AIM: This study aimed to investigate the process of homeostatic restoration in the tracheal mucosa (TM) after thyroid surgery. MATERIALS AND METHODS: Fifty-four rats were divided into normal controls (NC) and three experimental groups: (i) flap elevation (FE), (ii) thyroid exposure (TE), and (iii) thyroid isthmusectomy (TI). Expression of mRNA and proteins of key factors regulating homeostasis were evaluated in the TM obtained 3, 7, and 21 days after thyroid surgery. RESULTS: Increased mRNA expression of transforming growth factor-β1 (TGF-β1), hypoxia-inducible factor-1α (HIF-1α), and matrix metalloproteinase-9 (MMP-9) were observed 21 days after thyroid surgery in all experimental groups compared to that of NC group. CONCLUSION: Thyroid surgery leads to an actual increase of TGF-β1, HIF-1α, and MMP-9 expression in the TM. This increased expression of key regulators of homeostatic restoration in the TM lasts for a considerable period of time after surgery, especially if the extent of surgery increased.
Authors: Nicholas W Clavin; Tomer Avraham; John Fernandez; Sanjay V Daluvoy; Marc A Soares; Arif Chaudhry; Babak J Mehrara Journal: Am J Physiol Heart Circ Physiol Date: 2008-10-10 Impact factor: 4.733
Authors: Sang Woo Kim; Jin Youp Kim; Bo Hae Kim; Joo Hyun Park; Chang Gun Cho; Seok-Won Park; Yun-Sung Lim Journal: In Vivo Date: 2022 Sep-Oct Impact factor: 2.406