Literature DB >> 3496996

Differential induction of lupus associated antinuclear antibodies in MRL mice by monoclonal anti-Sm antibodies.

M R Stocks, D G Williams, R N Maini.   

Abstract

The effect of monoclonal autoantibodies on immunoregulation was investigated in MRL/MpJ-lpr/lpr mice. Passive transfer of KSm2 (a monoclonal IgG2a antibody directed against the 16 kD polypeptide of Sm) induced IgG antibodies to the other major immunoreactive polypeptides of Sm (28 and 29 kD) in all mice studied, and to polypeptides of the closely related antigen nRNP/Sm in 63% of the mice. In addition an increment in IgG anti-dsDNA antibodies, and in IgA and IgM anti-Sm antibodies, over control levels was observed. These effects were not due to polyclonal activation since anti-histone antibody levels were unaffected. Two other IgG2a monoclonal antibodies: KSm5 (directed against the 28 and 29 kD Sm polypeptides) and OX 12 (directed against an irrelevant antigen) failed to modulate the autoimmune responses of the mice in any way. These results demonstrate specific antibody-mediated connectivity between B cell clones producing autoantibodies against three distinct antigens.

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Year:  1987        PMID： 3496996      PMCID： PMC1542624     

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  16 in total

1.  Profiles of antinuclear antibodies in systemic rheumatic diseases.

Authors:  D D Notman; N Kurata; E M Tan
Journal:  Ann Intern Med       Date:  1975-10       Impact factor: 25.391

2.  Physical association of two nuclear antigens and mutual occurrence of their antibodies: the relationship of the SM and RNAprotein (MO) systems in SLE sera.

Authors:  M Mattioli; M Reichlin
Journal:  J Immunol       Date:  1973-05       Impact factor: 5.422

3.  Detection of antigens on nitrocellulose paper immunoblots with monoclonal antibodies.

Authors:  A L De Blas; H M Cherwinski
Journal:  Anal Biochem       Date:  1983-08       Impact factor: 3.365

4.  A high frequency idiotypic marker of anti-DNA autoantibodies in MRL-Ipr/Ipr mice.

Authors:  J Rauch; E Murphy; J B Roths; B D Stollar; R S Schwartz
Journal:  J Immunol       Date:  1982-07       Impact factor: 5.422

5.  IgM antibodies induce the production of antibodies of the same specificity.

Authors:  L Forni; A Coutinho; G Köhler; N K Jerne
Journal:  Proc Natl Acad Sci U S A       Date:  1980-02       Impact factor: 11.205

6.  Anti-Sm autoantibodies in MRL mice: in vitro detection and generation of antibody-forming cells.

Authors:  P L Cohen; R A Eisenberg
Journal:  J Immunol       Date:  1982-12       Impact factor: 5.422

7.  Characterization and idiotypic analysis of an anti-RNP monoclonal antibody.

Authors:  D S Pisetsky; D M Salistad; J C Chambers
Journal:  Clin Exp Immunol       Date:  1984-06       Impact factor: 4.330

8.  Administration of monoclonal anti-Sm antibody prolongs the survival and renal function of MRL-lpr/lpr mice.

Authors:  F M Brennan; D G Williams; D Bovill; M R Stocks; R N Maini
Journal:  Clin Exp Immunol       Date:  1986-07       Impact factor: 4.330

9.  Passive transfer of autoimmune disease with isologous IgG1 and IgG2 antibodies to the tubular basement membrane in strain XIII guinea pigs: loss of self-tolerance induced by autoantibodies.

Authors:  C L Hall; R B Colvin; K Carey; R T McCluskey
Journal:  J Exp Med       Date:  1977-11-01       Impact factor: 14.307

10.  Presence of anti-Sm reactivity in autoimmune mouse strains.

Authors:  R A Eisenberg; E M Tan; F J Dixon
Journal:  J Exp Med       Date:  1978-02-01       Impact factor: 14.307
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  10 in total

Review 1.  Anti-Sm autoantibodies in systemic lupus erythematosus mice: a model system for disease-specific autoreactivity.

Authors:  R A Eisenberg
Journal:  Springer Semin Immunopathol       Date:  1992

2.  Accelerated expression of anti-Sm and Y2 idiotype differ in dependence on T cell subsets in MRL/+ mice.

Authors:  M L Miller; H Dang; N Talal
Journal:  Clin Exp Immunol       Date:  1990-10       Impact factor: 4.330

3.  Regulation of the anti-Sm autoantibody response in systemic lupus erythematosus mice by monoclonal anti-Sm antibodies.

Authors:  R A Eisenberg; D S Pisetsky; S Y Craven; J P Grudier; M A O'Donnell; P L Cohen
Journal:  J Clin Invest       Date:  1990-01       Impact factor: 14.808

Review 4.  Lessons about autoantibody specificity in systemic lupus erythematosus from animal models.

Authors:  D I Stott
Journal:  Clin Exp Immunol       Date:  1990-07       Impact factor: 4.330

Review 5.  Regulation of autoreactive anti-IgG (rheumatoid factor) B cells in normal and autoimmune mice.

Authors:  H Wang; M J Schlomchik
Journal:  Immunol Res       Date:  1999       Impact factor: 2.829

Review 6.  Features of autoantigens.

Authors:  W H Reeves; M Satoh
Journal:  Mol Biol Rep       Date:  1996       Impact factor: 2.316

7.  Pathogenic natural anti-cardiolipin antibodies: the experience from monoclonal gammopathy.

Authors:  J Cohen; R Bakimer; M Blank; G Valesini; Y Shoenfeld
Journal:  Clin Exp Immunol       Date:  1994-08       Impact factor: 4.330

8.  Pathogenic serum IgG anticardiolipin antibodies and the idiotypic network.

Authors:  J Cohen; R Bakimer; M Blank; G Valesini; Y Shoenfeld
Journal:  Ann Rheum Dis       Date:  1993-10       Impact factor: 19.103

9.  Anti-nRNP anti-nuclear antibody-secreting cells are represented in the B-lymphocyte repertoire of normal and MRL/MP-lpr/lpr lupus mice.

Authors:  F M Brennan; E M Andrew; D G Williams; R N Maini
Journal:  Immunology       Date:  1988-02       Impact factor: 7.397

10.  Induction of a systemic lupus erythematosus-like disease in mice by a common human anti-DNA idiotype.

Authors:  S Mendlovic; S Brocke; Y Shoenfeld; M Ben-Bassat; A Meshorer; R Bakimer; E Mozes
Journal:  Proc Natl Acad Sci U S A       Date:  1988-04       Impact factor: 11.205
  10 in total

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