Literature DB >> 34966614

Physician-Perceived Barriers to Treating Opioid Use Disorder in the Emergency Department.

Gideon Logan1,2, Amber Mirajkar1,3,2, Jessica Houck4, Fernando Rivera-Alvarez1,2, Emily Drone5, Parth Patel1,2, Alexandra Craen6, Larissa Dub6,2, Nubaha Elahi6,2, David Lebowitz1,3,2,7, Ayanna Walker8,2, Latha Ganti1,3,2,7.   

Abstract

Objective We aimed to assess physicians' perceptions of barriers to starting medication-assisted treatment (MAT) in the Emergency Department (ED), views of the utility of MAT, and abilities to link patients with opioid use disorder (OUD) to MAT programs in their respective communities. Methods This was a cross-sectional survey study of American emergency medicine (EM) physicians with a self-administered online survey via SurveyMonkey (Survey Monkey, San Mateo, California). The survey was emailed to the Council of Residency Directors in Emergency Medicine (CORD) listserv and HCA Healthcare affiliated EM residency programs' listservs. Attendings and residents of all post-graduate years participated. Questions assessed perceptions of barriers to starting OUD patients on MAT, knowledge of the X-waiver, and knowledge of MAT details. Statistics were performed with JMP software (SAS Institute Inc., Cary, NC) using the two-tailed Z-test for proportions. Results There were 98 responses, with 33% female, 55% resident physicians, and an overall 17% response rate. Residents were more eager to start OUD patients on MAT (71% vs 52%, p=0.04) than attendings but were less familiar with the X-waiver (38% vs 73%, p=0.001) or where community outpatient MAT facilities were (21% vs 43%, p=0.02). Conclusion Barriers in the ED were identified as a shortage of qualified prescribers, the lengthy X-waiver process, and the poor availability of outpatient MAT resources. EM residents showed more willingness to prescribe MAT but lacked a core understanding of the process. This shows an area of improvement for residency training as well as advocacy among attendings.
Copyright © 2021, Logan et al.

Entities:  

Keywords:  buprenorphine; medication-assisted treatment; methadone; naltrexone; opioid; opioid epidemic; opioid use disorder; x-waiver

Year:  2021        PMID: 34966614      PMCID: PMC8710303          DOI: 10.7759/cureus.19923

Source DB:  PubMed          Journal:  Cureus        ISSN: 2168-8184


Introduction

The emergency department (ED) continues to exist as a primary avenue through which many patients receive medical care. This is particularly true for patients presenting with recreational drug overdoses and illicit drug-related complications [1]. In 2017, the United States reported just over 70,000 drug overdose deaths, of which 68% involved opioids; this represents an increase of 12% compared to 2016 [2]. Opioids are natural (e.g. morphine or codeine), semi-synthetic (e.g. hydrocodone or oxycodone), or synthetic substances (e.g. fentanyl, tramadol, methadone) that antagonize one of the three main opioid receptor systems (mu, kappa, delta), with the mu receptor being the most involved in addiction physiology. Although opioids can have analgesic effects, they also depress the central nervous system and cause euphoria, giving them a heightened potential for abuse. ED visits and hospitalization utilization for reasons related to opioid use continue to rise, which highlights the severity of this public health crisis [3]. An important component of caring for patients that use illicit drugs includes a discussion about initiating treatment for drug rehabilitation and addiction recovery services. For patients with opioid use disorder (OUD) in particular, medication-assisted treatment (MAT) is the standard of care [4]. Recently, the Substance Abuse and Mental Health Services Administration (SAMHSA) has proposed to replace the traditional term MAT with “medication for opioid use disorder” (MOUD), as MOUD has less stigma. Per the DSM-V, OUD is defined as “a problematic pattern of opioid use leading to clinically significant impairment or distress.” Specifically, in a 12-month period, two of the following must be present: (1) opioids are taken in larger amounts or over a longer period than was prescribed, (2) there is a persistent desire or unsuccessful effort to decrease opioid use, (3) a significant amount of time is spent in obtaining the opioid, using the opioid, and/or recovering from its effects, (4) experiencing a craving to use opioids, (5) recurrent opioid use resulting in failed obligations at work, school, and/or home, (6) continued opioid use despite recurrent social or interpersonal problems, (7) important social, occupational, or recreational activities are negatively affected secondary to opioid use, (8) recurrent opioid use in dangerous situations, (9) continued opioid use despite knowing the substance is causing a persistent physical, social, professional and/or psychological problem, (10) exhibits tolerance, and (11) exhibits withdrawal [5,6]. In OUD, MAT is the use of one of three medications (buprenorphine, naltrexone, or methadone) in combination with psychosocial and/or behavioral therapy to help combat addiction [5]. Buprenorphine is a partial mu-opioid receptor agonist with a long half-life, high potency, and “ceiling effect” for both euphoric sensation and adverse effects [7]. This makes it an optimal treatment alternative for patients with OUD presenting to the ED with opioid withdrawal. Furthermore, the buprenorphine/naloxone (ex. Suboxone®) combination can be taken by patients in any setting; they do not need to attend a daily clinic. However, given its high affinity for the receptor, if patients already have opioids on board, it could precipitate immediate withdrawal and all the complications associated with it (e.g. pulmonary edema, tachycardia, anxiety, nausea, vomiting, diarrhea, and abdominal pain). Naltrexone is a long-acting, competitive mu-opioid receptor antagonist, available orally and as a monthly extended-release intramuscular injection. Given it can out-compete opioids at the desired receptor, this medication can help prevent relapse. Although adherence and improved mortality for patients with OUD taking naltrexone are not as great as those using opioid-agonist-based MAT, naltrexone is still associated with decreased cravings and decreased rate of relapse, especially when combined with psychotherapy [8,9]. Furthermore, in Russia where there is no opioid-agonist-based MAT, a meta-analysis found that naltrexone demonstrated success in relapse prevention and abstinence stabilization [10]. Methadone is a racemic mixture, with one of its enantiomers having 10× the affinity for the μ-opioid receptor compared to opioids as well as antagonizing the N-methyl-d-aspartate (NMDA) receptor. Unlike buprenorphine, which is a partial μ-opioid receptor agonist, methadone is a full opioid agonist. Methadone is available in liquid and pill formulations, with both reaching maximum plasma concentrations by three hours. Its oral bioavailability is high (> 80%), and it has a potentially long half-life of 7-65 h [11]. However, methadone has well-known toxicities, including but not limited to arrhythmias (prolonged QTc), respiratory depression, and hypoglycemia. Furthermore, it has interactions with multiple other medications, as it is metabolized hepatically by the cytochrome P450 system. MAT is not a detoxification program, but rather an inclusive, long-term treatment plan after a patient has withdrawn from opioids. In the United States, buprenorphine and naltrexone-based MAT can only be started by a provider with a Drug Enforcement Agency (DEA) license and has undergone training for the Drug Addiction Treatment Act of 2000 (DATA 200) waiver. This is colloquially known as the “X-waiver.” Applications for the X-waiver are made through the SAMHS, which is a branch of the Department of Health and Human Services. At the time of this writing, this was the process, but there is a movement to remove the required training from the X-waiver application process. Typically, office-based physicians apply for the X-waiver, but emergency physicians can obtain an X-waiver to start MAT, too. For methadone-based MAT, patients need to be in an opioid treatment program (OTP) certified by SAMHSA [5]. Although the process of MAT seems complicated and necessitates more initial effort on the part of the physician, the evidence for MAT’s success is overwhelming. A 2018 meta-analysis showed that untreated participants had a higher risk of all-cause mortality and overdose mortality compared with those receiving MAT. In addition, retention in MAT of over one year was associated with a lower mortality rate than that with retention ≤1 year. Thus, authors found improved enrollment and adherence to MAT were crucial in reducing mortality in those with OUD [12]. Furthermore, the success of MAT in reducing mortality in those with OUD was demonstrated not only in the United States but also across the world. In Australia, a state-wide study between 1985 and 2006 with n = 42,676 showed treatment with methadone or buprenorphine reduced mortality by 29% compared with periods without treatment [13]. In Sweden, a longitudinal study using the Kaplan-Meier survival estimate technique found untreated patients with heroin dependency OUD had statistically significantly higher rates of mortality (63 times the rate expected without the disorder) compared to a group of former users in methadone maintenance programs (eight times the rate expected without the disorder) [14]. Although the road to recovery using MAT is challenging, starting patients with OUD on MAT is often the biggest hurdle to their success in battling the disease. As the ED is where many patients with OUD seek care, the ED is a preferred place to start MAT as opposed to referring patients to primary care doctors that many patients will never see or to programs they will not be able to enter for weeks to months. Moreover, initiating MAT in the ED can be lifesaving because there is a 5.5% one-year mortality associated with ED patients who presented with a non-fatal overdose [15]. A randomized control trial (RCT) studying 329 patients with OUD over four years found that ED-initiated buprenorphine treatment compared to brief, stabilizing interventions with outpatient referral significantly increased engagement with addiction treatment, reduced self-reported illicit opioid use, and decreased use of inpatient addiction treatment services [16]. Not only does MAT reduce mortality, but timely MAT improves compliance compared to behavior therapy alone [17]. Given that many patients with OUD frequent the ED, either for drug-related complaints (e.g. overdose and withdrawal) or for regular care (many patients with OUD do not have insurance and thus do not have primary doctors), emergency physicians can play a key role in starting this population on life-saving treatment. While the practicality and success of utilizing the ED to initiate MAT have been demonstrated in previous works [18,19], large-scale support of and participation with this model is lacking. Medications to start MAT can be difficult to access even for highly motivated individuals, mainly due to a shortage of prescribers and treatment programs [8]. Additionally, the lengthy X-waiver process mandated by the DATA 2000 to prescribe medications such as buprenorphine, Suboxone® (buprenorphine/naloxone), and naltrexone is an established obstacle [20]. For the opioid agonists specifically, despite being successfully utilized by many ED-based treatment programs, the stigma of “replacing one opioid with another” remains a barrier [7]. Evidence-based discussions between providers, administrators, and patients regarding the safety and benefits of these medications are essential to promoting a culture of acceptance and optimizing MAT in the ED. Our investigation sought to understand the factors contributing to the nationwide dearth of ED-based MAT, specifically in teaching settings. Given the proven efficacy of starting MAT in the ED and low overall participation rates of this practice in our own hospital, we sought to elucidate current views of the disconnect. In this study, we aimed to assess physicians’ perceptions of barriers to starting MAT in the ED, views of the utility of MAT, and the abilities of physicians to link OUD patients to MAT programs in their respective communities. We suspected a variety of reasons for the lack of implementation of MAT in the ED, including but not limited to lack of training, lack of knowledge of the process, a perception that the process was too lengthy or complicated, liability, and concerns that this model would promote further opioid abuse. We also wanted to assess differences in opinions between residents and attending physicians to identify potential teaching points that could enhance resident education.

Materials and methods

This was a cross-sectional survey study of American emergency medicine physicians affiliated with a residency program via a self-administered online survey using SurveyMonkey (Survey Monkey, San Mateo, CA) (Table 1).
Table 1

Survey instrument

QuestionAnswer Choices
1. Genderfree text
2. Years in practice after medical schoolfree text
3. Do you know what an X-waiver is?a. yes
b. no
4. Would you be interested in obtaining an X-waiver?a. yes
b. no
5. Would you be interested in starting patients battling opiate addiction on suboxone, if they were interested?a. yes
b. no
6. Do you know where to send a patient to obtain clean needles?a. yes
b. no
7. Do you know where to send a patient for HIV/hepatitis testing?a. yes
b. no
8. Are you aware of any suboxone clinics in your community?a. yes
b. no
9. Have you ever referred a patient to a suboxone clinic?a. yes
b. no
10. Do you believe suboxone can help a patient recover from addiction?a. strongly agree
b. agree
c. disagree
d. strongly disagree
11. Are you aware of community resources for rehabilitation programs?a. yes
b. no
12. Do you think it would be helpful to hand out naloxone (Narcan®) to patients battling opiate addiction and also to their families?a. strongly agree
b. agree
c. disagree
d. strongly disagree
13. Do you think handing out naloxone (Narcan®) condones opiate use?a. yes
b. no
Questions were generated de novo by the authors and are not based on an existing model. Recipients of the survey came from the following email mailing lists (listservs): Council of Residency Directors in Emergency Medicine (CORD) and Hospital Corporation of America (HCA) affiliated emergency medicine residency programs across the USA. There was a single email announcement to the entire CORD listserv with no incentives and no reminders. The authors contacted all the HCA emergency medicine residency program directors, who forwarded the survey to all members of their residency (i.e. interns, residents, fellows, and attendings) in a single announcement with no reminders or incentives. Questions consisted of either multiple-choice or yes/no answers to assess perceptions of barriers to starting OUD patients on MAT. Respondents self-reported the number of years in practice out of medical school with values of four years and fewer considered to be residents and five years and greater to be attendings. For our purposes, a facility capable of MAT was one that could provide at a minimum buprenorphine/naloxone (Suboxone®) treatment. Statistics were performed by JMP software (SAS Institute Inc., Cary, NC) with a two-tailed Z-test of proportions. Approval was obtained from HCA Healthcare Institutional Review Board (IRB). There were no sponsors or funding organizations involved in our research. There were no prizes, gifts, or compensation for those who answered the survey.

Results

A total of 98 physicians out of 576 responded to the survey, with 33% female, 55% resident physicians, and an overall 17% response rate. An overwhelming majority, 80% of respondents, demonstrated an interest in starting OUD patients on MAT, such as buprenorphine/naloxone (Suboxone®), and 94% either “agreed” or “strongly agreed” that MAT was helpful for OUD patients to overcome addiction. However, only 53% had knowledge of the X-waiver (mandated training to prescribe buprenorphine/naloxone [Suboxone®] long-term with the federal DEA), and only 32% knew of an outpatient community facility capable of continuing buprenorphine/naloxone (Suboxone®) management. When dividing responses by the level of training, residents were more eager to start OUD patients on MAT (71% vs 52%, p=0.04) than attendings but were less familiar with what the X-waiver was (38% vs 73%, p=0.001), where community outpatient MAT facilities were (21% vs 43%, p=0.02), or having ever referred OUD patients to MAT programs in their individual practice (7% vs 30%, p=0.003) (Figure 1).
Figure 1

Responses to MAT survey comparing attendings and residents

MAT - medication-assisted treatment

Responses to MAT survey comparing attendings and residents

MAT - medication-assisted treatment There was no distinction between post-graduate years in the responses; the survey was open to all emergency medicine residents in an attempt to represent the entire population of nascent doctors. There were no differences between residents and attendings in the perception of the utility of MAT for OUD patients (96% vs 90%, p=0.27) or perception of condoning continued opiate use by prescribing naloxone (Narcan®) to discharged OUD patients from the ED (14% vs 15%, p=0.85). In comparing female vs male respondents, the only significant difference was seen in whether giving naloxone condoned opiate use (6% female vs 20% male, p=0.02). In other words, males were more likely to think that prescribing naloxone condoned opiate use. Otherwise, answers to questions were not statistically significant between males and females.

Discussion

With the opioid epidemic highlighted by multiple professional medical societies and mainstream media, emergency medicine physicians are keenly aware of the suffering from OUD. The goal of this survey was to assess any physician perceived barriers and current practice experience with starting and referring OUD patients to MAT. Overwhelming support was seen among all levels of emergency medicine physicians to start OUD patients on MAT, which represents an important cultural shift in how we approach this vulnerable patient population. There were no differences between female and male respondents (overall and within training levels), except when all females were less likely to think that giving naloxone condones opiate use compared to all males (p < 0.05). This suggests the differences in opinions between attendings and residents is not attributable to gender differences but rather differences in the prevailing thoughts on OUD from training in medical schools and residencies at different points in time. The data further suggest the need for more robust residency training about OUD, MAT, the X-waiver process, and the ED’s role in the timely bridging of patients with OUD to gold-standard treatment. A willingness to start OUD patients on MAT was greater in resident-level physicians compared to attendings, but the knowledge of prescribing details and referring to qualified centers fell behind that of attendings. Residency training can consider including X-waiver requirements prior to starting residency or include it as part of first-month onboarding. Resident-run initiatives should also be encouraged to capitalize on their enthusiasm to treat OUD patients. Additionally, teaching faculty and residency program leadership should model behaviors that encourage residents to continue MAT prescribing in their practices after graduation. It is unclear based on our survey why attending physicians overall were more hesitant. A follow-up survey study can be used to further investigate this significant pattern. At the time of this writing, those wishing to obtain an X-waiver had to apply through SAMSHA and complete training. However, there was speculation about the training being removed for those physicians treating less than 30 patients. This likely would not affect emergency medicine residents or attendings, as both groups see more than 30 patients with OUD per year. Furthermore, this survey was administered based upon the process at the time, which mandated the training. Unfortunately, the vital, widespread support from hospital and health system administrations, group leaderships, and insurance policies to efficiently enact meaningful changes in the ED approach to OUD patients were not assessed. However, the views and abilities of emergency physicians to start MAT remains an important component of that system. The X-waiver itself is a barrier to initiating effective MAT and becoming waivered will remain an integral part of helping OUD patients until laws can be changed to ease the requirement. At the time of this writing, there was an effort on behalf of professional medical organizations such as the American College of Emergency Physicians (ACEP) and the American Medical Association (AMA) at the federal level attempting to remove the X-waiver process and at the very least streamline it. Available outpatient clinics that continue MAT are independent of emergency medicine physicians’ abilities and scope of practice, but maintaining close relationships with these facilities and widespread distribution of information on available resources is critical to MAT’s success. Many EDs have had success in starting their own ED-based MAT clinics but have required extensive hospital support [18]. Given these obstacles, patients with OUD desperate to wean themselves from opioids or treat their opioid dependence may turn to alternative agents. These agents include using prescription medications, such as clonidine or gabapentin, in an off-label capacity or over-the-counter medications, such as loperamide, in supratherapeutic doses. Finally, individuals may use herbal supplements like kratom to prevent opioid withdrawal, which is increasingly dangerous as the Food and Drug Administration (FDA) does not regulate these supplements. Each of these therapies for OUD is associated with unique toxicities that providers should recognize, as patients will likely minimalize in their attempt to self-treat [11]. Further research is needed across non-HCA Healthcare emergency medicine residencies and in EDs that do not have a residency program to fully represent emergency physicians’ views. Additionally, with the advancement of emergency department ARNPs and PAs, they should also be surveyed regarding their views of OUD, MAT, and the X-waiver. Finally, there are different barriers and stigma throughout the country, so it would be prudent to further delineate views by region and have targeted education for each of those regions to reduce their specific bias. Limitations A major limitation of our study was a response rate of only 17% of the listservs members surveyed. Given the small sample size, it might be difficult to extrapolate our findings to residents and attendings nationwide secondary to sample bias. We neither performed a non-responder survey nor analyzed the demographics of those who did not respond. Another limitation is the population of emergency medicine residents. The residency classes that were surveyed were all HCA-affiliated emergency medicine residency programs, which are primarily located in the Atlantic South region. Thus, our sample may not represent practice patterns for all residency programs across the country. Many of the emergency medicine residencies are at hybrid community hospitals as well as tertiary urban centers. Furthermore, these EDs are all under the direction of HCA Healthcare, which has its own approval processes, and not all EDs have MAT medications like methadone, naltrexone, and buprenorphine available in the ED even if the emergency physicians had obtained an X-waiver. The organization is aware of the need for MAT and MAT-trained providers, which is why they started four addiction medicine fellowships in 2020 and plan to add even more over the coming years [21]. However, it is not clear if these fellows will be able to offer ED-based MAT. The CORD listserv included a greater geographic representation of attendings but by definition are not solely community-based practicing attendings. Therefore, the CORD responses may not represent the population of community-based providers. Despite the limitations, our results could be arguably extrapolated to HCA Healthcare emergency departments in the Atlantic South that, according to the 2020 US Census, has over a third of the US population, which has grown compared to previous Census years [22]. This implies that, although our sample residents are largely from one area of the country, these are the providers that are and will be caring for a large portion of the nation’s patients.

Conclusions

In summary, support for MAT is robust among all levels of emergency medicine physicians but knowledge of community resources and required training (like the X-waiver) to prescribe certain forms of MAT remains a barrier. When comparing resident physicians to attending physicians, the knowledge gap of community MAT facilities and the practice of referring OUD patients for MAT is wide, demonstrating clear areas of residency training to bolster. Additionally, resident physicians expressed more willingness to initiate MAT for patients with OUD, and therefore allowing resident-run initiatives during residency program could encourage quicker adaptation of MAT prescribing in the ED. Finally, perhaps more MAT advocacy is needed for attendings. The ED is increasingly becoming the starting point to propel patients with OUD into appropriate MAT programs and emergency medicine physicians are willing and eager to help.
Table 2

Survey Reponses Data

   At which program are you currently working/affiliated?Do you know what an X waiver is?Would you be interested in obtaining an X waiver?Would you be interested in starting patients battling opiate addiction on Suboxone®, if they were interested?Do you know where to send a patient to obtain clean needles?Do you know where to send a patient for HIV/hepatitis testing?Are you aware of any Suboxone® clinics in your community?Have you ever referred a patient to a Suboxone® clinic?Do you believe Suboxone® can help a patient recover from addiction?Are you aware of community resources for rehabilitation programs?Do you think it would be helpful to hand out naloxone (Narcan®) to patients battling opiate addiction and also to their families?Do you think handing out naloxone (Narcan®) condones opiate use?
FemaleMaleYears in practice after medical school:Aventura Hospital and Medical CenterOak Hill HospitalNorth Florida Regional Medical Center (Gainesville)Kendall Regional Medical CenterOcala Regional Medical CenterOsceola Regional Medical CenterColiseum Medical CenterOrange Park Medical CenterBrandon Regional HospitalMountainView Hospital- Sunrise HealthGrand Strand Regional Medical CenterRiverside Community Hospital/ University of California RiversideSt. Lucie Medical CenterCouncil of Emergency Medicine Residency Director List ServOther (please specify)YesNoYesNoYesNoYesNoYesNoYesNoYesNoStrongly agreeAgreeDisagreeStrongly disagreeYesNoStrongly agreeAgreeDisagreeStrongly disagreeYesNo
Female 1    X           NoYes Yes  NoYes  No No Agree  Yes  Agree   No
 Male2   X            No No No No No No No Agree   NoStrongly agree    No
 Male2    X           No NoYes  NoYes  No No Agree  Yes  Agree   No
 Male1      X        Yes Yes Yes  NoYes  No No Agree  Yes  Agree   No
Female 2   X            NoYes Yes  NoYes  No No Agree   No Agree   No
 Male2   X            NoYes Yes  No No No No Agree   NoStrongly agree    No
Female 1    X           No NoYes  NoYes  No NoStrongly agree    No Agree  Yes 
 Male12  X            Yes  No No NoYes  No No Agree  Yes Strongly agree    No
 Male20  X             No NoYes  NoYes Yes  No Agree  Yes  Agree   No
 Male1  X            Yes Yes Yes  No No No No Agree   NoStrongly agree    No
 Male3    X           NoYes Yes  NoYes  No NoStrongly agree    NoStrongly agree    No
 Male1      X         NoYes Yes  NoYes  No No Agree  Yes  Agree   No
Female 1      X         NoYes Yes  NoYes  No NoStrongly agree    NoStrongly agree    No
 Male1      X        Yes Yes Yes  No No No NoStrongly agree   Yes  Agree   No
                            Yes Yes  Agree   NoStrongly agree    No
 Male1      X         NoYes Yes  No No No No Agree  Yes  Agree  Yes 
 Male22      X        Yes Yes Yes  NoYes Yes  No Agree  Yes  Agree  Yes 
 Male25     X          No NoYes  NoYes  No NoStrongly agree    No Agree  Yes 
 Male2              Franciscan-Midwestern University Chicago NoYes Yes  NoYes Yes  No  Disagree Yes Strongly agree    No
 Male9              TTUHSC El PasoYes Yes Yes  NoYes  No NoStrongly agree   Yes  Agree   No
 Male3              Midwestern/St James Emergency Medicine Residency No No No NoYes  No No Agree  Yes  Agree   No
 Male26              TTUHSC El Paso No No No NoYes  No No Agree  Yes  Agree   No
 Male2         X      NoYes Yes Yes  No No No Agree  Yes Strongly agree    No
 Male5              Texas Tech University Medical Center No NoYes  NoYes  No No Agree  Yes   Disagree Yes 
 Male9              Midwestern University/CCOM EMYes  No No NoYes Yes Yes  Agree  Yes Strongly agree    No
 Male6              Franciscan Health Olympia Fields Emergency MedicineYes Yes Yes Yes Yes  No No Agree  Yes  Agree  Yes 
Female 2X               NoYes Yes  NoYes  No No Agree  Yes  Agree   No
Female 3X              Yes Yes Yes  No No No NoStrongly agree   Yes Strongly agree    No
 Male11             X Yes Yes Yes  NoYes  No No Agree  Yes  Agree   No
 Male3              Franciscan Health Olympia Fields Emergency Medicine No NoYes  NoYes  No NoStrongly agree    NoStrongly agree    No
Female 13             X Yes Yes Yes  No No No No Agree  Yes Strongly agree    No
Female 1              Jefferson Health Northeast No NoYes  No NoYes  NoStrongly agree   Yes Strongly agree    No
 Male5              TTUHSC El PasoYes Yes Yes Yes Yes Yes Yes Strongly agree   Yes Strongly agree    No
Female 4     X         Yes Yes Yes  NoYes  No No Agree   No Agree   No
Female 9     X          No No No NoYes Yes Yes   Disagree Yes  Agree   No
Female 2              Jefferson Health NortheastYes Yes  NoYes Yes Yes  NoStrongly agree   Yes Strongly agree    No
 Male3     X          NoYes Yes  No NoYes  NoStrongly agree    NoStrongly agree    No
 Male1     X         Yes  No NoYes Yes Yes  No Agree  Yes  Agree   No
Female 3              Jefferson Health Northeast No NoYes Yes Yes  No NoStrongly agree   Yes Strongly agree    No
Female 3     X          NoYes Yes  NoYes  No NoStrongly agree    NoStrongly agree    No
  3              Jefferson Health Northeast No No No NoYes  No NoStrongly agree   Yes Strongly agree    No
 Male16              Jefferson Health NortheastYes  No No NoYes  NoYes   Disagree Yes  Agree   No
 Male4              Jefferson Health NortheastYes Yes Yes Yes Yes Yes Yes Strongly agree   Yes  Agree  Yes 
Female 8              Jefferson NE TorresdaleYes Yes Yes Yes Yes  No No Agree  Yes  Agree   No
 Male3              Texas Tech University Medical CenterYes Yes Yes  No No No NoStrongly agree    No   Strongly disagreeYes 
 Male18              Jefferson Health NortheastYes Yes Yes  NoYes Yes Yes Strongly agree   Yes Strongly agree    No
 Male1              TTUHSC El Paso NoYes Yes  No No No No Agree  Yes  Agree  Yes 
 Male13              UMKC- Truman Medical CenterYes Yes Yes  NoYes Yes Yes Strongly agree   Yes Strongly agree    No
 Male25              TTUHSC El PasoYes Yes Yes Yes Yes Yes Yes  Agree  Yes Strongly agree    No
 Male5              TTUHSC El Paso NoYes  No NoYes  No No Agree  Yes  Agree   No
 Male6              TTUHSC El PasoYes  NoYes  NoYes  No NoStrongly agree   Yes  Agree  Yes 
 Male1              TTUHSC El PasoYes Yes Yes  NoYes Yes  No Agree   No Agree   No
 Male2              TTUHSC El PasoYes Yes Yes  No No No NoStrongly agree   Yes Strongly agree    No
 Male22              TTUHSC El PasoYes  No No NoYes Yes  No Agree  Yes   Disagree Yes 
Female 12             X Yes Yes Yes Yes Yes Yes Yes Strongly agree   Yes Strongly agree    No
 Male11              TTUHSC El Paso No NoYes  NoYes  No No Agree  Yes  Agree   No
Female 2.5              TTUHSC El PasoYes Yes Yes  NoYes Yes Yes Strongly agree   Yes Strongly agree    No
 Male13              TTUHSC El PasoYes Yes Yes  No No No NoStrongly agree   Yes  Agree   No
 Male38             X Yes Yes Yes  No NoYes  NoStrongly agree   Yes  Agree   No
 Male9              TTUHSC El PasoYes Yes Yes  NoYes  No No Agree  Yes  Agree   No
Female 24              TTUHSC El Paso No NoYes  NoYes  No No Agree  Yes  Agree   No
 Male19              LewisGale Medical Center No No No NoYes  No No  Disagree Yes  Agree   No
Female 11             X Yes  NoYes  NoYes  No No Agree  Yes Strongly agree    No
Female 10             X Yes  No No NoYes  No No Agree  Yes Strongly agree    No
 Male14             X Yes Yes Yes Yes Yes Yes Yes Strongly agree   Yes Strongly agree    No
 Male13              Thomas Jefferson UniversityYes Yes Yes  No NoYes Yes  Agree   NoStrongly agree    No
Female 1  X            Yes  NoYes  NoYes  No No Agree  Yes Strongly agree    No
Female 2     X          NoYes Yes  NoYes  No NoStrongly agree    NoStrongly agree    No
Female 2        X       No NoYes  No NoYes Yes  Agree  Yes  Agree  Yes 
 Male1        X      Yes Yes Yes  NoYes  No No Agree  Yes  Agree   No
 Male3     X          NoYes Yes  NoYes  No No Agree  Yes  Agree  Yes 
 Male1     X          NoYes Yes  No No No No Agree  Yes  Agree   No
 Male1     X         Yes Yes Yes  NoYes  No NoStrongly agree   Yes Strongly agree    No
Female 2     X         Yes Yes Yes  No NoYes Yes Strongly agree    NoStrongly agree    No
 Male3     X          NoYes Yes  NoYes  No NoStrongly agree   Yes  Agree   No
 Male2     X          NoYes Yes  NoYes  No No Agree  Yes  Agree   No
Female 3     X          NoYes Yes  NoYes  No No   Strongly disagreeYes  Agree   No
Female 17           X   Yes  NoYes  No NoYes Yes Strongly agree   Yes Strongly agree    No
 Male2     X          NoYes  No NoYes  No No Agree  Yes  Agree   No
Female 3           X    NoYes Yes  No No No NoStrongly agree   Yes Strongly agree    No
 Male1           X    No NoYes  NoYes  No No Agree   NoStrongly agree    No
 Male2         X     Yes Yes Yes Yes  No No NoStrongly agree   Yes Strongly agree    No
 Male21           X    No NoYes  NoYes  No No Agree  Yes  Agree   No
 Male28           X   Yes Yes Yes  NoYes Yes Yes  Agree  Yes Strongly agree    No
 Male11           X   Yes Yes Yes  NoYes Yes  No Agree  Yes Strongly agree    No
 Male1           X    No NoYes  NoYes  No No Agree  Yes  Agree   No
 Male2         X     Yes  No No NoYes  No No Agree  Yes   Disagree Yes 
Female 19     X         Yes  No No No NoYes  No  Disagree Yes  Agree   No
 Male2        X      Yes  NoYes  NoYes Yes  No Agree  Yes  Agree  Yes 
Female 2     X         Yes Yes Yes  NoYes Yes  No Agree  Yes  Agree   No
 Male19         X      NoYes  No NoYes  No No Agree  Yes   Disagree  No
Female 23     X         Yes  No No NoYes Yes  No Agree  Yes  Agree   No
 Male2    X           NoYes Yes  NoYes  No NoStrongly agree   Yes Strongly agree    No
Female 2  X            Yes Yes Yes  NoYes  No No Agree   NoStrongly agree    No
 Male15  X            Yes  No No NoYes  No No Agree  Yes Strongly agree    No
 Male1     X          No NoYes  NoYes  No No Agree  Yes  Agree   No
Female 10     X         Yes Yes Yes  NoYes  No No Agree  Yes Strongly agree    No
Female 2     X         Yes Yes Yes  NoYes  No NoStrongly agree    NoStrongly agree    No
Female 8     X          No NoYes  NoYes  No No Agree  Yes  Agree   No
 Male1               Yes Yes Yes  NoYes Yes Yes Strongly agree   Yes Strongly agree    No
Total female: 33Total female: 65Average years out of medical school: 7.420635226 34070733                          
33.30%66.30%Median years out of medical school: 3               53% yes46% no62.6% yes37.3% no79.7% yes20% no12% yes87.8% no76.7% yes23.2% no32% yes68% no18% yes82% no36% strongly agree58% Agree5% Disagree1% Strongly disagree79% yes21% no46% Strongly agree49% Agree4% Disagree1% Strongly diagree15% yes85% no
  17 in total

1.  Mortality in heroin addiction: impact of methadone treatment.

Authors:  L Grönbladh; L S Ohlund; L M Gunne
Journal:  Acta Psychiatr Scand       Date:  1990-09       Impact factor: 6.392

Review 2.  Use of naltrexone to treat opioid addiction in a country in which methadone and buprenorphine are not available.

Authors:  Evgeny Krupitsky; Edwin Zvartau; George Woody
Journal:  Curr Psychiatry Rep       Date:  2010-10       Impact factor: 5.285

3.  One-Year Mortality of Patients After Emergency Department Treatment for Nonfatal Opioid Overdose.

Authors:  Scott G Weiner; Olesya Baker; Dana Bernson; Jeremiah D Schuur
Journal:  Ann Emerg Med       Date:  2019-06-20       Impact factor: 5.721

Review 4.  Approach to buprenorphine use for opioid withdrawal treatment in the emergency setting.

Authors:  David H Cisewski; Cynthia Santos; Alex Koyfman; Brit Long
Journal:  Am J Emerg Med       Date:  2018-10-11       Impact factor: 2.469

5.  Mortality among clients of a state-wide opioid pharmacotherapy program over 20 years: risk factors and lives saved.

Authors:  Louisa Degenhardt; Deborah Randall; Wayne Hall; Matthew Law; Tony Butler; Lucy Burns
Journal:  Drug Alcohol Depend       Date:  2009-07-15       Impact factor: 4.492

Review 6.  Potential uses of naltrexone in emergency department patients with opioid use disorder.

Authors:  Evan Stuart Bradley; David Liss; Stephanie Pepper Carreiro; David Eric Brush; Kavita Babu
Journal:  Clin Toxicol (Phila)       Date:  2019-03-04       Impact factor: 4.467

7.  Effects of medication-assisted treatment on mortality among opioids users: a systematic review and meta-analysis.

Authors:  Jun Ma; Yan-Ping Bao; Ru-Jia Wang; Meng-Fan Su; Mo-Xuan Liu; Jin-Qiao Li; Louisa Degenhardt; Michael Farrell; Frederic C Blow; Mark Ilgen; Jie Shi; Lin Lu
Journal:  Mol Psychiatry       Date:  2018-06-22       Impact factor: 15.992

8.  Receipt of Timely Addiction Treatment and Association of Early Medication Treatment With Retention in Care Among Youths With Opioid Use Disorder.

Authors:  Scott E Hadland; Sarah M Bagley; Jonathan Rodean; Michael Silverstein; Sharon Levy; Marc R Larochelle; Jeffrey H Samet; Bonnie T Zima
Journal:  JAMA Pediatr       Date:  2018-11-01       Impact factor: 16.193

9.  No end to the crisis without an end to the waiver.

Authors:  Joseph W Frank; Sarah E Wakeman; Adam J Gordon
Journal:  Subst Abus       Date:  2018       Impact factor: 3.716

10.  Drug and Opioid-Involved Overdose Deaths - United States, 2013-2017.

Authors:  Lawrence Scholl; Puja Seth; Mbabazi Kariisa; Nana Wilson; Grant Baldwin
Journal:  MMWR Morb Mortal Wkly Rep       Date:  2018-01-04       Impact factor: 17.586

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