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Literature DB >> 3496501

Peripheral blood and tumor-infiltrating mononuclear cell analysis in esophagus and head and neck cancer.

P Lozac'h, P Corbeau, C Zabbe, J F Charles, P Youinou.

Abstract

We show a significantly decreased number of OKT3+ lymphocytes in the peripheral blood (PB) of cancer patients mainly due to a reduced number of OKT4 cells. OKT8 cells were also somewhat reduced. The numbers of DR+ and interleukin-2 receptor-bearing T-cells were significantly increased in patients. The tumor-infiltrating cells included OKT4+ AND OKT8+ lymphocytes. There was a significant correlation between the proportion of activated T-cells in PB and in tumor, as shown by DR and interleukin-2 receptor expression.

Entities: Disease Gene Species

Mesh：

Substances：
Antibodies, Monoclonal

Year: 1987 PMID： 3496501 DOI： 10.1007/BF02934928

Source DB: PubMed Journal: Med Oncol Tumor Pharmacother ISSN： 0736-0118

16 in total

1. Separation of functional subsets of human T cells by a monoclonal antibody.

Authors: E L Reinherz; P C Kung; G Goldstein; S F Schlossman
Journal: Proc Natl Acad Sci U S A Date: 1979-08 Impact factor: 11.205

2. A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).

Authors: T Abo; C M Balch
Journal: J Immunol Date: 1981-09 Impact factor: 5.422

3. Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody.

Authors: P C Beverley; R E Callard
Journal: Eur J Immunol Date: 1981-04 Impact factor: 5.532

1. Radiation and surgical stress induce a significant impairment in cellular immunity in patients with esophageal cancer.

Authors: Y Yokoyama; K Sakamoto; M Arai; M Akagi
Journal: Jpn J Surg Date: 1989-09

1 in total

Peripheral blood and tumor-infiltrating mononuclear cell analysis in esophagus and head and neck cancer.

1. Separation of functional subsets of human T cells by a monoclonal antibody.

2. A differentiation antigen of human NK and K cells identified by a monoclonal antibody (HNK-1).

3. Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody.

4. Enumeration of T lymphocyte subsets by monoclonal antibodies in young and aged humans.

5. Evidence of cells bearing interleukin-2 receptor at sites of disease activity in sarcoid patients.

6. Concanavalin A-inducible suppressor cells in regional lymph nodes of cancer patients.

7. Comparison of immune derangements in patients with different malignancies.

Review 8. Nutrition and the immune response -- a review.

Review 9. Lymphocyte migration in malignant disease.

10. T lymphocyte subsets in the peripheral blood of patients with benign and malignant breast disease.

1. Radiation and surgical stress induce a significant impairment in cellular immunity in patients with esophageal cancer.