Luca Giovanelli1,2, Richard Quinton3,4. 1. Department of Medical Biotechnology and Translational Medicine, University of Milan, 20100 Milan, Italy. 2. Department of Endocrine and Metabolic Medicine, IRCCS Istituto Auxologico Italiano, 20100 Milan, Italy. 3. Department of Endocrinology, Diabetes & Metabolism, Newcastle-upon-Tyne Hospitals, Newcastle Upon Tyne NE1 4LP, UK. 4. Translational & Clinical Research Institute, University of Newcastle-upon-Tyne, Newcastle Upon Tyne NE1 3BZ,UK.