Skin anti-inflammatory activity of water-soluble fullerene nanocomposites encompassed by sodium hyaluronate.

Fullerene is one of the nanomaterials that has a value in dermatological and cosmetic applications. In present work, we designed and prepared water-soluble nano-scale C60 encompassed by sodium hyaluronate. The rat ear swelling test was utilized to evaluate the anti-inflammatory activity of encompassed C60. The measurement shows that the rat ear swelling rate of C60 administrated group is reduced to less than 10%, which shows good anti-inflammatory activity. Its anti-inflammatory activity is roughly calculated as 10 times than that of dipotassium glycyrrhizinate and five times than that of tanshinone. In conclusion, the fullerenes encapsulated by sodium hyaluronate have great potential in skin care and auxiliary treatment of dermatosis.