Literature DB >> 3496153

Phase II trial of MVE-II in metastatic malignant melanoma.

J Rinehart, J LaForge, D Gochnour, J Neidhart.   

Abstract

MVE-II, a low molecular weight fraction of pyran copolymer was utilized in a Phase II trial in patients with metastatic malignant melanoma. A total of 15 patients were investigated and no clinical responses or immunologic responses were observed. We concluded that MVE-II is not an active agent in malignant melanoma.

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Year:  1987        PMID： 3496153     DOI： 10.1007/BF00205637

Source DB:  PubMed          Journal:  Cancer Immunol Immunother        ISSN： 0340-7004            Impact factor:   6.968


  9 in total

Review 1.  The routinization of intraperitoneal (intracavitary) chemotherapy and immunotherapy.

Authors:  W Regelson; G Parker
Journal:  Cancer Invest       Date:  1986       Impact factor: 2.176

2.  Combined drug and immunostimulation therapy against a syngeneic murine leukemia.

Authors:  J W Pearson; M A Chirigos; S D Chaparas; N A Sher
Journal:  J Natl Cancer Inst       Date:  1974-02       Impact factor: 13.506

3.  Divinyl ether-maleic anhydride (pyran) copolymer used to demonstrate the effect of molecular weight on biological activity.

Authors:  D S Breslow; E I Edwards; N R Newburg
Journal:  Nature       Date:  1973-11-16       Impact factor: 49.962

4.  Effect of interferon inducers and interferon on bacterial infections.

Authors:  D J Giron; J P Schmidt; R J Ball; F F Pindak
Journal:  Antimicrob Agents Chemother       Date:  1972-01       Impact factor: 5.191

5.  Relationship of molecular weight to antiviral and antitumor activities and toxic effects of maleic anhydride-divinyl ether (MVE) polyanions.

Authors:  P S Morahan; D W Barnes; A E Munson
Journal:  Cancer Treat Rep       Date:  1978-11

6.  Response of murine leukemia to combined BCNU-maleic anhydride-vinyl ether (MVE) adjuvant therapy and correlation with macrophage activation by MVE in the in vitro growth inhibition assay.

Authors:  J H Dean; M L Padarathsingh; L Keys
Journal:  Cancer Treat Rep       Date:  1978-11

7.  Effect of maleic anhydride-divinyl ether copolymers on experimental M109 metastases and macrophage tumoricidal function.

Authors:  N A Pavlidis; R M Schultz; M A Chirigos; J Luetzeler
Journal:  Cancer Treat Rep       Date:  1978-11

8.  Evaluation of the immunological and toxicological properties of MVE-2 in phase I trials.

Authors:  J J Rinehart; D C Young; J A Neidhart
Journal:  Cancer Res       Date:  1983-05       Impact factor: 12.701

Review 9.  The biological activity of the synthetic polyanion, pyran copolymer (diveema, MVE, 46015) and the heterocyclic bis DEAE fluorenone derivative, tilorone and congeners: clinical and laboratory effects of these agents as modulators of host resistance.

Authors:  W Regelson
Journal:  Pharmacol Ther       Date:  1981       Impact factor: 12.310
  9 in total

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