Literature DB >> 3496079

Ionizing-radiation-induced damage in the DNA of cultured human cells. Identification of 8,5-cyclo-2-deoxyguanosine.

M Dizdaroglu, M L Dirksen, H X Jiang, J H Robbins.   

Abstract

Epstein-Barr-virus-transformed peripheral-blood B-lymphocytes were gamma-irradiated at 0 degree C at doses from 10 to 100 Gy. The cells were immediately lysed and the DNA was isolated. Subsequently, the DNA was hydrolysed to 2'-deoxyribonucleosides with a mixture of DNAase I, venom and spleen exonucleases and alkaline phosphatase. The hydrolysate was dried, trimethylsilylated and analysed by capillary gas chromatography-mass spectrometry with selected-ion monitoring. The (5'R)- and (5'S)-diastereomers of 8,5'-cyclo-2'-deoxyguanosine were observed in a ratio of 1:3, and their formation was dose-dependent. It was possible to detect and characterize one such lesion in approx. 4 X 10(4) guanine nucleotide subunits of DNA.

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Year:  1987        PMID： 3496079      PMCID： PMC1147650          DOI： 10.1042/bj2410929

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  9 in total

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Journal:  Int J Radiat Biol Relat Stud Phys Chem Med       Date:  1985-02

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Journal:  Anal Biochem       Date:  1986-07       Impact factor: 3.365

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Authors:  M Dizdaroglu
Journal:  Biochem J       Date:  1986-08-15       Impact factor: 3.857

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5.  Stereoselective intramolecular cyclization in irradiated nucleic acids: R- and S-8,5'-cycloadenosine in polyadenylic acid.

Authors:  A F Fuciarelli; F Y Shum; J A Raleigh
Journal:  Biochem Biophys Res Commun       Date:  1986-01-29       Impact factor: 3.575

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Journal:  Radiat Res       Date:  1981-05       Impact factor: 2.841

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9.  Application of capillary gas chromatography-mass spectrometry to chemical characterization of radiation-induced base damage of DNA: implications for assessing DNA repair processes.

Authors:  M Dizdaroglu
Journal:  Anal Biochem       Date:  1985-02-01       Impact factor: 3.365
  9 in total
  19 in total

Review 1.  Induction, repair and biological relevance of radiation-induced DNA lesions in eukaryotic cells.

Authors:  M Frankenberg-Schwager
Journal:  Radiat Environ Biophys       Date:  1990       Impact factor: 1.925

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Authors:  Jean Cadet; Kelvin J A Davies; Marisa Hg Medeiros; Paolo Di Mascio; J Richard Wagner
Journal:  Free Radic Biol Med       Date:  2017-01-02       Impact factor: 7.376

Review 3.  Repair of oxidatively induced DNA damage by DNA glycosylases: Mechanisms of action, substrate specificities and excision kinetics.

Authors:  Miral Dizdaroglu; Erdem Coskun; Pawel Jaruga
Journal:  Mutat Res Rev Mutat Res       Date:  2017-02-16       Impact factor: 5.657

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Authors:  Hai Huang; Rajat S Das; Ashis K Basu; Michael P Stone
Journal:  J Am Chem Soc       Date:  2011-11-21       Impact factor: 15.419

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Authors:  K Miaskiewicz; J H Miller; A F Fuciarelli
Journal:  Nucleic Acids Res       Date:  1995-02-11       Impact factor: 16.971

Review 6.  The case for 8,5'-cyclopurine-2'-deoxynucleosides as endogenous DNA lesions that cause neurodegeneration in xeroderma pigmentosum.

Authors:  P J Brooks
Journal:  Neuroscience       Date:  2006-12-19       Impact factor: 3.590

7.  Generation of guanine-amino acid cross-links by a free radical combination mechanism.

Authors:  Yuriy Uvaydov; Nicholas E Geacintov; Vladimir Shafirovich
Journal:  Phys Chem Chem Phys       Date:  2014-05-09       Impact factor: 3.676

8.  Accumulation of (5'S)-8,5'-cyclo-2'-deoxyadenosine in organs of Cockayne syndrome complementation group B gene knockout mice.

Authors:  Güldal Kirkali; Nadja C de Souza-Pinto; Pawel Jaruga; Vilhelm A Bohr; Miral Dizdaroglu
Journal:  DNA Repair (Amst)       Date:  2008-11-18

9.  Induction of 8,5'-cyclo-2'-deoxyadenosine and 8,5'-cyclo-2'-deoxyguanosine in isolated DNA by Fenton-type reagents.

Authors:  Candace R Guerrero; Jin Wang; Yinsheng Wang
Journal:  Chem Res Toxicol       Date:  2013-09-04       Impact factor: 3.739

Review 10.  The 8,5'-cyclopurine-2'-deoxynucleosides: candidate neurodegenerative DNA lesions in xeroderma pigmentosum, and unique probes of transcription and nucleotide excision repair.

Authors:  P J Brooks
Journal:  DNA Repair (Amst)       Date:  2008-05-20
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