William Ambler1,2, Laura Santambrogio3,4, Theresa T Lu1,2,5,6. 1. Autoimmunity and Inflammation Program, Hospital for Special Surgery. 2. Pediatric Rheumatology, Department of Medicine, Hospital for Special Surgery. 3. Englander Institute of Precision Medicine. 4. Radiation Oncology, Weill Cornell Medicine. 5. Rheumatology, Department of Medicine, Hospital for Special Surgery. 6. Department of Microbiology and Immunology, Weill Cornell Medicine, New York, New York, USA.
Abstract
PURPOSE OF REVIEW: The aim of this review is to give insights into how novel lymphatics functions may influence autoimmunity. RECENT FINDINGS: The lymphatic system connects peripheral tissues to draining lymph nodes to regulate adaptive immunity and directly interfaces with leukocytes in lymph vessels and in the lymph node. Here, we discuss recent findings showing evidence of dysfunctional lymphatics in autoimmune disease, new understanding of how afferent lymphatic regulation can modulate immunity, lymph node lymphatic heterogeneity and how these lymphatics can directly modulate lymphocyte function, how this understanding can be harnessed for new therapeutics, and new tools for the investigation of lymphatic and immune biology. SUMMARY: Lymphatics have an active role in the regulation of inflammation and the adaptive immune response. Here, we review recent findings in lymphatics biology in peripheral tissues and lymph nodes and emphasize the relevance for better understanding autoimmune diseases.
PURPOSE OF REVIEW: The aim of this review is to give insights into how novel lymphatics functions may influence autoimmunity. RECENT FINDINGS: The lymphatic system connects peripheral tissues to draining lymph nodes to regulate adaptive immunity and directly interfaces with leukocytes in lymph vessels and in the lymph node. Here, we discuss recent findings showing evidence of dysfunctional lymphatics in autoimmune disease, new understanding of how afferent lymphatic regulation can modulate immunity, lymph node lymphatic heterogeneity and how these lymphatics can directly modulate lymphocyte function, how this understanding can be harnessed for new therapeutics, and new tools for the investigation of lymphatic and immune biology. SUMMARY: Lymphatics have an active role in the regulation of inflammation and the adaptive immune response. Here, we review recent findings in lymphatics biology in peripheral tissues and lymph nodes and emphasize the relevance for better understanding autoimmune diseases.
Authors: Wenjing Xu; Nathan P Nelson-Maney; László Bálint; Hyouk-Bum Kwon; Reema B Davis; Danielle C M Dy; James M Dunleavey; Brad St Croix; Kathleen M Caron Journal: Int J Mol Sci Date: 2022-05-20 Impact factor: 6.208